Protein detail
TSN16
Tetraspanin-16 (Tspan-16) (Tetraspanin TM4-B) (Transmembrane 4 superfamily member 16)
Entry name TSN16 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 4 | Protein classification Predicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information12
Protein Names
Tetraspanin-16 (Tspan-16) (Tetraspanin TM4-B) (Transmembrane 4 superfamily member 16)
Protein Class
Predicted membrane proteins
Transmembrane
14..34; Helical; 38..58; Helical; 60..80; Helical; 95..115; Helical
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
TM-8TM4-BTM4SF16
Gene Description
Tetraspanin 16
Chromosome
19
Position
11296139-11326996
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization1
Tissue Specificbrain
Function & Pathway4
Cellular Component (2)
Molecular Function
Biological Process (3)
Mediation Categories
Other mediation
Relations & Evidence15
Ligand-Receptor Signaling (14)
14 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | HPMR | No | Yes | No | Yes | No |
| tetraspanins | receptor | HPMR | No | Yes | No | Yes | No |
| tm4sf5 | receptor | HPMR | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| extracellular | extracellular | HPMR | No | No | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Antibody array | 0 |
Sequence, Structure & Domains7
Sequences
Length
245
Mass
26,266
Sequence
MAEIHTPYSSLKKLLSLLNGFVAVSGIILVGLGIGGKCGGASLTNVLGLSSAYLLHVGNLCLVMGCITVLLGCAGWYGATKESRGTLLFCILSMVIVLIMEVTAATVVLLFFPIVGDVALEHTFVTLRKNYRGYNEPDDYSTQWNLVMEKLKCCGVNNYTDFSGSSFEMTTGHTYPRSCCKSIGSVSCDGRDVSPNVIHQKGCFHKLLKITKTQSFTLSGSSLGAAVIQRWGSRYVAQAGLELLA
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9UKR8-1; Sequence=Displayed; Name=2; IsoId=Q9UKR8-2; Sequence=VSP_056726; Name=3; IsoId=Q9UKR8-3; Sequence=VSP_056723, VSP_056726; Name=4; IsoId=Q9UKR8-4; Sequence=VSP_056724, VSP_056725
Alternative Sequence
90..114; Missing (in isoform 3); 151..160; LKCCGVNNYT -> GLSKYFFSSL (in isoform 4); 161..245; Missing (in isoform 4); 230..245; RWGSRYVAQAGLELLA -> LPGILATLLLFIKLG (in isoform 2 and isoform 3)
Domain & Motif Annotations
Protein Families
Tetraspanin (TM4SF) family
Sequence Similarities
Belongs to the tetraspanin (TM4SF) family.
Clinical Relevance1
Antibody
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 34063765 | Proteomic Exploration of Plasma Exosomes and Other Small Extracellular Vesicles in Pediatric Hodgkin Lymphoma: A Potential Source of Biomarkers for Relapse Occurrence. | No abstract available |