Protein detail

PACN3

Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511)

Entry name
PACN3
UniProt ID
EVMP score
0.38
Frequency
2
Transmembrane count
Protein classification
Plasma proteinsPredicted intracellular proteins
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511)
Protein Class
Plasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Entrez Gene Symbol
Gene Synonym
SDPIII
Gene Description
Protein kinase C and casein kinase substrate in neurons 3
Chromosome
11
Position
47177522-47186443
Frequency
2
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificheart muscleCell SpecificCardiomyocytesSingle-Nuclei Brain Specificastrocyte
Function & Pathway
Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

8 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularComPPINoNoNoNoNo
intracellularintracellularGO_IntercellNoNoNoNoNo
intracellularintracellularUniProt_locationNoNoNoNoNo
intracellularintracellularOmniPathNoNoNoNoNo
fbar_actin_dynamics_endocytosisintracellular_intercellular_relatedHGNCYesNoNoNoNo
intracellular_intercellular_relatedintracellular_intercellular_relatedOmniPathYesNoNoNoNo
plasma_membraneplasma_membraneUniProt_locationNoNoNoNoNo
plasma_membraneplasma_membraneOmniPathNoNoNoNoNo

Regulatory Interaction Network

0 records.

Protein Complex Composition

1 record.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
PACSIN3ST13P50502Q9UKS60:0hu.MAPhu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity CaptureMass spectrometryELISA738113368373224753889596241068253318059583743863832854315
Sequence, Structure & Domains

Sequences

Length
424
Mass
48,487
Sequence
MAPEEDAGGEALGGSFWEAGNYRRTVQRVEDGHRLCGDLVSCFQERARIEKAYAQQLADWARKWRGTVEKGPQYGTLEKAWHAFFTAAERLSALHLEVREKLQGQDSERVRAWQRGAFHRPVLGGFRESRAAEDGFRKAQKPWLKRLKEVEASKKSYHAARKDEKTAQTRESHAKADSAVSQEQLRKLQERVERCAKEAEKTKAQYEQTLAELHRYTPRYMEDMEQAFETCQAAERQRLLFFKDMLLTLHQHLDLSSSEKFHELHRDLHQGIEAASDEEDLRWWRSTHGPGMAMNWPQFEEWSLDTQRTISRKEKGGRSPDEVTLTSIVPTRDGTAPPPQSPGSPGTGQDEEWSDEESPRKAATGVRVRALYDYAGQEADELSFRAGEELLKMSEEDEQGWCQGQLQSGRIGLYPANYVECVGA

3D Structural Models

Domain & Motif Annotations

Compositional Bias
155..176; Basic and acidic residues; 311..321; Basic and acidic residues
Coiled Coil
23..272
Domain (CC)
The F-BAR domain forms a coiled coil and mediates membrane-binding and membrane tubulation.
Domain (FT)
10..280; F-BAR; 363..424; SH3
Region
155..184; Disordered; 311..364; Disordered
Protein Families
PACSIN family
Sequence Similarities
Belongs to the PACSIN family.
Clinical Relevance
Interaction Protein
ENSG00000039560ENSG00000082438ENSG00000100106ENSG00000100266ENSG00000106078ENSG00000106299ENSG00000124507
Interaction Count
7
Interaction Dataset
biogrid_opencellintact_biogrid_opencellintact_biogridintact_biogrid_bioplex