Protein detail
PACN3
Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511)
Entry name PACN3 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 2 | Transmembrane count | Protein classification Plasma proteinsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511)
Protein Class (2)
Plasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
SDPIII
Gene Description
Protein kinase C and casein kinase substrate in neurons 3
Chromosome
11
Position
47177522-47186443
Supporting publications (n)
2
EVMP confidence score
0.38
Fluorescence & Localization3
Tissue Specificheart muscleCell SpecificCardiomyocytesSingle-Nuclei Brain Specificastrocyte
Function & Pathway6
Protein Function
Predicted intracellular proteins
Cellular Component (5)
Molecular Function (6)
Biological Process (3)
Reactome (3)
Mediation Categories
Fusion and delivery mediation
Relations & Evidence10
Ligand-Receptor Signaling (8)
8 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| fbar_actin_dynamics_endocytosis | intracellular_intercellular_related | HGNC | Yes | No | No | No | No |
| intracellular_intercellular_related | intracellular_intercellular_related | OmniPath | Yes | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Protein Complex Composition (1)
Sequence, Structure & Domains10
Sequences
Length
424
Mass
48,487
Sequence
MAPEEDAGGEALGGSFWEAGNYRRTVQRVEDGHRLCGDLVSCFQERARIEKAYAQQLADWARKWRGTVEKGPQYGTLEKAWHAFFTAAERLSALHLEVREKLQGQDSERVRAWQRGAFHRPVLGGFRESRAAEDGFRKAQKPWLKRLKEVEASKKSYHAARKDEKTAQTRESHAKADSAVSQEQLRKLQERVERCAKEAEKTKAQYEQTLAELHRYTPRYMEDMEQAFETCQAAERQRLLFFKDMLLTLHQHLDLSSSEKFHELHRDLHQGIEAASDEEDLRWWRSTHGPGMAMNWPQFEEWSLDTQRTISRKEKGGRSPDEVTLTSIVPTRDGTAPPPQSPGSPGTGQDEEWSDEESPRKAATGVRVRALYDYAGQEADELSFRAGEELLKMSEEDEQGWCQGQLQSGRIGLYPANYVECVGA
Domain & Motif Annotations
Compositional Bias
155..176; Basic and acidic residues; 311..321; Basic and acidic residues
Coiled Coil
23..272
Domain (CC)
The F-BAR domain forms a coiled coil and mediates membrane-binding and membrane tubulation.
Domain (FT)
10..280; F-BAR; 363..424; SH3
Region
155..184; Disordered; 311..364; Disordered
Protein Families
PACSIN family
Sequence Similarities
Belongs to the PACSIN family.
Clinical Relevance4
Supporting Publications2
| PMID | Title | Abstract |
|---|---|---|
| 27894104 | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | No abstract available |
| 32089743 | Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism. | No abstract available |