Protein detail

PACN3

Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511)

Entry name
PACN3
UniProt ID
Q9UKS6
EVMP confidence score
0.40
Supporting publications (n)
2
Transmembrane count
Protein classification
Plasma proteinsPredicted intracellular proteins
Basic Information
Protein Names
Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511)
Protein Class (2)
Plasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
ENSG00000165912
Entrez Gene Symbol
PACSIN3
Gene Synonym
SDPIII
Gene Description
Protein kinase C and casein kinase substrate in neurons 3
Chromosome
11
Position
47177522-47186443
Supporting publications (n)
2
EVMP confidence score
0.40
Fluorescence & Localization
Tissue Specificheart muscleCell SpecificCardiomyocytesSingle-Nuclei Brain Specificastrocyte
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component (5)
Molecular Function (6)
Biological Process (3)
Reactome (3)
Mediation Categories
Fusion and delivery mediation
Relations & Evidence10

Ligand-Receptor Signaling (8)

8 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularComPPI
intracellularintracellularGO_Intercell
intracellularintracellularUniProt_location
intracellularintracellularOmniPath
fbar_actin_dynamics_endocytosisintracellular_intercellular_relatedHGNCYes
intracellular_intercellular_relatedintracellular_intercellular_relatedOmniPathYes
plasma_membraneplasma_membraneUniProt_location
plasma_membraneplasma_membraneOmniPath

Protein Complex Composition (1)

1 record.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
PACSIN3ST13P50502Q9UKS60:0hu.MAPhu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity CaptureMass spectrometryELISA738113368373224753889596241068253318059583743863832854315
Sequence, Structure & Domains

Sequences

Length
424
Mass
48,487
Sequence
MAPEEDAGGEALGGSFWEAGNYRRTVQRVEDGHRLCGDLVSCFQERARIEKAYAQQLADWARKWRGTVEKGPQYGTLEKAWHAFFTAAERLSALHLEVREKLQGQDSERVRAWQRGAFHRPVLGGFRESRAAEDGFRKAQKPWLKRLKEVEASKKSYHAARKDEKTAQTRESHAKADSAVSQEQLRKLQERVERCAKEAEKTKAQYEQTLAELHRYTPRYMEDMEQAFETCQAAERQRLLFFKDMLLTLHQHLDLSSSEKFHELHRDLHQGIEAASDEEDLRWWRSTHGPGMAMNWPQFEEWSLDTQRTISRKEKGGRSPDEVTLTSIVPTRDGTAPPPQSPGSPGTGQDEEWSDEESPRKAATGVRVRALYDYAGQEADELSFRAGEELLKMSEEDEQGWCQGQLQSGRIGLYPANYVECVGA

Domain & Motif Annotations

Compositional Bias
155..176; Basic and acidic residues; 311..321; Basic and acidic residues
Coiled Coil
23..272
Domain (CC)
The F-BAR domain forms a coiled coil and mediates membrane-binding and membrane tubulation.
Domain (FT)
10..280; F-BAR; 363..424; SH3
Region
155..184; Disordered; 311..364; Disordered
Protein Families
PACSIN family
Sequence Similarities
Belongs to the PACSIN family.
Clinical Relevance
Antibody (2)
HPA039480HPA043904
Interaction Protein (7)
ENSG00000039560ENSG00000082438ENSG00000100106ENSG00000100266ENSG00000106078ENSG00000106299ENSG00000124507
Interaction Count
7
Interaction Dataset (4)
biogrid_opencellintact_biogrid_opencellintact_biogridintact_biogrid_bioplex
Supporting Publications2
PMIDTitleRelated sentences
27894104Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.No related sentences available
32089743Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism.No related sentences available