Protein detail
ITA11
Integrin alpha-11
Protein symbol ITA11 | UniProt ID | EVMP score 0.38 |
Frequency | Transmembrane count 1 | Protein classification Predicted membrane proteinsTransporters |
Basic Information
Protein Names
Integrin alpha-11
Protein Class
Predicted membrane proteinsTransporters
Protein Function
Transporters:Accessory Factors Involved in Transport
Transmembrane
1142..1164; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
HsT18964
Gene Description
Integrin subunit alpha 11
Chromosome
15
Position
68296532-68432163
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecificgallbladderCell SpecificCholangiocytes
Function & Pathway
Protein Function
Transporters:Accessory Factors Involved in Transport
Cellular Component
Molecular Function
Biological Process
KEGG
- hsa04151 PI3K-Akt signaling pathway
- KEGG:hsa04510 Focal adhesion
- KEGG:hsa04512 ECM-receptor interaction
- KEGG:hsa04518 Integrin signaling
- KEGG:hsa04810 Regulation of actin cytoskeleton
- KEGG:hsa04820 Cytoskeleton in muscle cells
- KEGG:hsa05165 Human papillomavirus infection
- KEGG:hsa05410 Hypertrophic cardiomyopathy
- KEGG:hsa05412 Arrhythmogenic right ventricular cardiomyopathy
- KEGG:hsa05414 Dilated cardiomyopathy
Reactome
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
57 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellPhoneDB | No | Yes | No | Yes | No |
| receptor | receptor | GO_Intercell | No | Yes | No | Yes | No |
| receptor | receptor | HPMR | No | Yes | No | Yes | No |
| receptor | receptor | ICELLNET | No | Yes | No | Yes | No |
| receptor | receptor | CellTalkDB | No | Yes | No | Yes | No |
| receptor | receptor | Surfaceome | No | Yes | No | Yes | No |
| receptor | receptor | Ramilowski2015 | No | Yes | No | Yes | No |
| receptor | receptor | LRdb | No | Yes | No | Yes | No |
| integrin | receptor | Integrins | No | Yes | No | Yes | No |
| integrin | receptor | UniProt_keyword | No | Yes | No | Yes | No |
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Regulatory Interaction Network
3 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| SP1 | P08047 | ITA11 | Q9UKX5 | Yes | Yes | No | SIGNOR | SIGNOR:16300938 |
| ETS1 | P14921 | ITA11 | Q9UKX5 | Yes | Yes | No | SIGNOR | SIGNOR:16300938 |
| SP3 | Q02447 | ITA11 | Q9UKX5 | Yes | Yes | No | SIGNOR | SIGNOR:16300938 |
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
1,188
Mass
133,470
Sequence
MDLPRGLVVAWALSLWPGFTDTFNMDTRKPRVIPGSRTAFFGYTVQQHDISGNKWLVVGAPLETNGYQKTGDVYKCPVIHGNCTKLNLGRVTLSNVSERKDNMRLGLSLATNPKDNSFLACSPLWSHECGSSYYTTGMCSRVNSNFRFSKTVAPALQRCQTYMDIVIVLDGSNSIYPWVEVQHFLINILKKFYIGPGQIQVGVVQYGEDVVHEFHLNDYRSVKDVVEAASHIEQRGGTETRTAFGIEFARSEAFQKGGRKGAKKVMIVITDGESHDSPDLEKVIQQSERDNVTRYAVAVLGYYNRRGINPETFLNEIKYIASDPDDKHFFNVTDEAALKDIVDALGDRIFSLEGTNKNETSFGLEMSQTGFSSHVVEDGVLLGAVGAYDWNGAVLKETSAGKVIPLRESYLKEFPEELKNHGAYLGYTVTSVVSSRQGRVYVAGAPRFNHTGKVILFTMHNNRSLTIHQAMRGQQIGSYFGSEITSVDIDGDGVTDVLLVGAPMYFNEGRERGKVYVYELRQNLFVYNGTLKDSHSYQNARFGSSIASVRDLNQDSYNDVVVGAPLEDNHAGAIYIFHGFRGSILKTPKQRITASELATGLQYFGCSIHGQLDLNEDGLIDLAVGALGNAVILWSRPVVQINASLHFEPSKINIFHRDCKRSGRDATCLAAFLCFTPIFLAPHFQTTTVGIRYNATMDERRYTPRAHLDEGGDRFTNRAVLLSSGQELCERINFHVLDTADYVKPVTFSVEYSLEDPDHGPMLDDGWPTTLRVSVPFWNGCNEDEHCVPDLVLDARSDLPTAMEYCQRVLRKPAQDCSAYTLSFDTTVFIIESTRQRVAVEATLENRGENAYSTVLNISQSANLQFASLIQKEDSDGSIECVNEERRLQKQVCNVSYPFFRAKAKVAFRLDFEFSKSIFLHHLEIELAAGSDSNERDSTKEDNVAPLRFHLKYEADVLFTRSSSLSHYEVKPNSSLERYDGIGPPFSCIFRIQNLGLFPIHGMMMKITIPIATRSGNRLLKLRDFLTDEANTSCNIWGNSTEYRPTPVEEDLRRAPQLNHSNSDVVSINCNIRLVPNQEINFHLLGNLWLRSLKALKYKSMKIMVNAALQRQFHSPFIFREEDPSRQIVFEISKQEDWQVPIWIIVGSTLGGLLLLALLVLALWKLGFFRSARRRREPGLDPTPKVLE
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UKX5-1; Sequence=Displayed; Name=2; IsoId=Q9UKX5-2; Sequence=VSP_053416
Alternative Sequence
1029; E -> EV (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Repeat
24..85; FG-GAP 1; 91..151; FG-GAP 2; 355..406; FG-GAP 3; 411..461; FG-GAP 4; 462..527; FG-GAP 5; 528..586; FG-GAP 6; 590..650; FG-GAP 7
Domain (CC)
The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
Domain (FT)
164..345; VWFA
Protein Families
Integrin alpha chain family
Sequence Similarities
Belongs to the integrin alpha chain family.
Clinical Relevance
Antibody