Protein detail

MKLN1

Muskelin

Entry name MKLN1	UniProt ID Q9UL63	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Muskelin

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000128585

Entrez Gene Symbol

MKLN1

Gene Synonym

TWA2

Gene Description

Muskelin 1

Chromosome

Position

131110096-131496632

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization1

Function & Pathway7

Protein Function

Predicted intracellular proteins

Cellular Component (9)

Molecular Function (3)

Biological Process (3)

Reactome (3)

Canonical Pathways

M222 Pid cxcr3 pathway

Mediation Categories (3)

Adhesion and uptake mediationFusion and delivery mediationMetabolism mediation

Relations & Evidence23

Ligand-Receptor Signaling (5)

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (17)

17 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
CTLH complex	ARMC8 MAEA MKLN1 RANBP9 RMND5A	Q7L5Y9 Q8IUR7 Q96S59 Q9H871 Q9UL63	1:1:1:1:1	CompleatCORUM	Compleat:HC727CORUM:3071	17467196
GID E3 ubiquitin ligase complexRMND5A-RANBP10 variant	ARMC8 GID4 GID8 MAEA MKLN1 RANBP10 RMND5A WDR26 YPEL5	P62699 Q6VN20 Q7L5Y9 Q8IUR7 Q8IVV7 Q9H7D7 Q9H871 Q9NWU2 Q9UL63	1:1:1:1:1:1:1:1:1	ComplexPortal		14755292 35682545 33905682
GID E3 ubiquitin ligase complexRMND5A-RANBP9 variant	ARMC8 GID4 GID8 MAEA MKLN1 RANBP9 RMND5A WDR26 YPEL5	P62699 Q7L5Y9 Q8IUR7 Q8IVV7 Q96S59 Q9H7D7 Q9H871 Q9NWU2 Q9UL63	1:1:1:1:1:1:1:1:1	ComplexPortal	PDB:7NSC	14755292 35682545 33905682
GID E3 ubiquitin ligase complexRMND5B-RANBP10 variant	ARMC8 GID4 GID8 MAEA MKLN1 RANBP10 RMND5B WDR26 YPEL5	P62699 Q6VN20 Q7L5Y9 Q8IUR7 Q8IVV7 Q96G75 Q9H7D7 Q9NWU2 Q9UL63	1:1:1:1:1:1:1:1:1	ComplexPortal		14755292 35682545 33905682
GID E3 ubiquitin ligase complexRMND5B-RANBP9 variant	ARMC8 GID4 GID8 MAEA MKLN1 RANBP9 RMND5B WDR26 YPEL5	P62699 Q7L5Y9 Q8IUR7 Q8IVV7 Q96G75 Q96S59 Q9H7D7 Q9NWU2 Q9UL63	1:1:1:1:1:1:1:1:1	ComplexPortal	PDB:7NSC	14755292 35682545 33905682
RANBPM-Muskelin-TWA1-HSMpp8 complex	GID8 MKLN1 MPHOSPH8 RANBP9	Q96S59 Q99549 Q9NWU2 Q9UL63	1:1:1:1	CompleatCORUM	Compleat:HC2021CORUM:639	12559565
	ARMC8 CRIPTO GID4 GID8 HTRA2 MAEA MKLN1 RANBP10 RANBP9 RMND5A RMND5B WDR26 YPEL5 ZMYND19	O43464 P13385 P62699 Q6VN20 Q7L5Y9 Q8IUR7 Q8IVV7 Q96E35 Q96G75 Q96S59 Q9H7D7 Q9H871 Q9NWU2 Q9UL63	0:0:0:0:0:0:0:0:0:0:0:0:0:0	hu.MAP2
	CFAP410 GID8 MKLN1 RANBP9 RNPS1 WDR26 YPEL5	O43822 P62699 Q15287 Q96S59 Q9H7D7 Q9NWU2 Q9UL63	1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5515
	ARMC8 CRIPTO GID4 GID8 MAEA MKLN1 RANBP10 RANBP9 RMND5A WDR26 YPEL5 ZMYND19	P13385 P62699 Q6VN20 Q7L5Y9 Q8IUR7 Q8IVV7 Q96E35 Q96S59 Q9H7D7 Q9H871 Q9NWU2 Q9UL63	0:0:0:0:0:0:0:0:0:0:0:0	hu.MAP2
	CLK2 MARK3 MKLN1 SREK1 SRSF1 SRSF2	P27448 P49760 Q01130 Q07955 Q8WXA9 Q9UL63	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9388

Page 1 of 2Next

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Western blotting	3	38731868 25471207 40098346

Sequence, Structure & Domains9

Sequences

Length

735

Mass

84,768

Sequence

MAAGGAVAAAPECRLLPYALHKWSSFSSTYLPENILVDKPNDQSSRWSSESNYPPQYLILKLERPAIVQNITFGKYEKTHVCNLKKFKVFGGMNEENMTELLSSGLKNDYNKETFTLKHKIDEQMFPCRFIKIVPLLSWGPSFNFSIWYVELSGIDDPDIVQPCLNWYSKYREQEAIRLCLKHFRQHNYTEAFESLQKKTKIALEHPMLTDIHDKLVLKGDFDACEELIEKAVNDGLFNQYISQQEYKPRWSQIIPKSTKGDGEDNRPGMRGGHQMVIDVQTETVYLFGGWDGTQDLADFWAYSVKENQWTCISRDTEKENGPSARSCHKMCIDIQRRQIYTLGRYLDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAADGGPKLVFDHQMCMDSEKHMIYTFGGRILTCNGSVDDSRASEPQFSGLFAFNCQCQTWKLLREDSCNAGPEDIQSRIGHCMLFHSKNRCLYVFGGQRSKTYLNDFFSYDVDSDHVDIISDGTKKDSGMVPMTGFTQRATIDPELNEIHVLSGLSKDKEKREENVRNSFWIYDIVRNSWSCVYKNDQAAKDNPTKSLQEEEPCPRFAHQLVYDELHKVHYLFGGNPGKSCSPKMRLDDFWSLKLCRPSKDYLLRHCKYLIRKHRFEEKAQVDPLSALKYLQNDLYITVDHSDPEETKEFQLLASALFKSGSDFTALGFSDVDHTYAQRTQLFDTLVNFFPDSMTPPKGNLVDLITL

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UL63-1; Sequence=Displayed; Name=2; IsoId=Q9UL63-2; Sequence=VSP_021852

Alternative Sequence

1..207; Missing (in isoform 2)

3D Structural Models

3D Structure

Electron microscopy (1)

Domain & Motif Annotations

Repeat

284..330; Kelch 1; 339..391; Kelch 2; 408..458; Kelch 3; 469..515; Kelch 4; 526..578; Kelch 5; 597..651; Kelch 6

Domain (CC)

The LisH mediates head to tail dimerization.

Domain (FT)

172..204; LisH; 206..258; CTLH

Clinical Relevance4

Antibody (2)

HPA022817 HPA041810

Interaction Protein (9)

ENSG00000010017ENSG00000090316ENSG00000101193ENSG00000114098ENSG00000141034ENSG00000141084ENSG00000153561ENSG00000162923ENSG00000165724

Interaction Count

Interaction Dataset (3)

intact_biogrid_opencellintact_biogridintact_biogrid_bioplex

Supporting Publications1

PMID	Title	Abstract
40784529	Serum-derived exosome proteomics unveils the distinct and adjustable nature of the dampness constitution in traditional Chinese medicine.	No abstract available