Protein detail
S39AA
Zinc transporter ZIP10 (Solute carrier family 39 member 10) (Zrt- and Irt-like protein 10) (ZIP-10)
Entry name S39AA | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 9 | Transmembrane count 7 | Protein classification Essential proteinsMetabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Zinc transporter ZIP10 (Solute carrier family 39 member 10) (Zrt- and Irt-like protein 10) (ZIP-10)
Protein Class (5)
Essential proteinsMetabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function (2)
- Transporters:Electrochemical Potential-driven transporters
- Predicted intracellular proteins
Transmembrane
411..431; Helical; 438..458; Helical; 495..515; Helical; 687..707; Helical; 732..752; Helical; 759..779; Helical; 801..821; Helical
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
DKFZp564L2123FLJ90515KIAA1265
Gene Description
Solute carrier family 39 member 10
Chromosome
2
Position
195575977-195737702
Supporting publications (n)
9
EVMP confidence score
0.50
Function & Pathway7
Protein Function (2)
- Transporters:Electrochemical Potential-driven transporters
- Predicted intracellular proteins
Cellular Component (2)
Molecular Function (3)
Biological Process (3)
Reactome (5)
Mediation Categories (2)
Fusion and delivery mediationImmune mediation
Relations & Evidence26
Ligand-Receptor Signaling (24)
24 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| transporter | transporter | Surfaceome | No | Yes | No | Yes | No |
| solute_carrier | transporter | Almen2009 | No | Yes | No | Yes | No |
| slc39 | transporter | Surfaceome | No | Yes | No | Yes | No |
| slc | transporter | Surfaceome | No | Yes | No | Yes | No |
| transporter | transporter | OmniPath | No | Yes | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
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Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Western blotting | 1 | 36064647 |
Sequence, Structure & Domains9
Sequences
Length
831
Mass
94,132
Sequence
MKVHMHTKFCLICLLTFIFHHCNHCHEEHDHGPEALHRQHRGMTELEPSKFSKQAAENEKKYYIEKLFERYGENGRLSFFGLEKLLTNLGLGERKVVEINHEDLGHDHVSHLDILAVQEGKHFHSHNHQHSHNHLNSENQTVTSVSTKRNHKCDPEKETVEVSVKSDDKHMHDHNHRLRHHHRLHHHLDHNNTHHFHNDSITPSERGEPSNEPSTETNKTQEQSDVKLPKGKRKKKGRKSNENSEVITPGFPPNHDQGEQYEHNRVHKPDRVHNPGHSHVHLPERNGHDPGRGHQDLDPDNEGELRHTRKREAPHVKNNAIISLRKDLNEDDHHHECLNVTQLLKYYGHGANSPISTDLFTYLCPALLYQIDSRLCIEHFDKLLVEDINKDKNLVPEDEANIGASAWICGIISITVISLLSLLGVILVPIINQGCFKFLLTFLVALAVGTMSGDALLHLLPHSQGGHDHSHQHAHGHGHSHGHESNKFLEEYDAVLKGLVALGGIYLLFIIEHCIRMFKHYKQQRGKQKWFMKQNTEESTIGRKLSDHKLNNTPDSDWLQLKPLAGTDDSVVSEDRLNETELTDLEGQQESPPKNYLCIEEEKIIDHSHSDGLHTIHEHDLHAAAHNHHGENKTVLRKHNHQWHHKHSHHSHGPCHSGSDLKETGIANIAWMVIMGDGIHNFSDGLAIGAAFSAGLTGGISTSIAVFCHELPHELGDFAVLLKAGMTVKQAIVYNLLSAMMAYIGMLIGTAVGQYANNITLWIFAVTAGMFLYVALVDMLPEMLHGDGDNEEHGFCPVGQFILQNLGLLFGFAIMLVIALYEDKIVFDIQF
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9ULF5-1; Sequence=Displayed; Name=2; IsoId=Q9ULF5-2; Sequence=VSP_055991
Alternative Sequence
1..450; Missing (in isoform 2)
Domain & Motif Annotations
Compositional Bias
138..147; Polar residues; 152..171; Basic and acidic residues; 172..188; Basic residues; 189..198; Basic and acidic residues; 211..221; Polar residues; 229..238; Basic residues; 256..273; Basic and acidic residues; 281..315; Basic and acidic residues
Region
126..318; Disordered; 464..484; Disordered
Protein Families
ZIP transporter (TC 2.A.5) family
Sequence Similarities
Belongs to the ZIP transporter (TC 2.A.5) family.
Clinical Relevance4
Supporting Publications9
| PMID | Title | Abstract |
|---|---|---|
| 27894104 | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | No abstract available |
| 28986585 | Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics. | No abstract available |
| 32089743 | Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism. | No abstract available |
| 33035814 | Knockout of PRDX6 induces mitochondrial dysfunction and cell cycle arrest at G2/M in HepG2 hepatocarcinoma cells. | No abstract available |
| 34817906 | Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform. | No abstract available |
| 35611462 | Extracellular vesicles expressing CEACAM proteins in the urine of bladder cancer patients. | No abstract available |
| 37786918 | Rapid and in-depth proteomic profiling of small extracellular vesicles for ultralow samples. | No abstract available |
| 38321535 | Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles. | No abstract available |
| 40748658 | Exosomes released from senescent cells and circulatory exosomes isolated from human plasma reveal aging-associated proteomic and lipid signatures. | No abstract available |