Protein detail

S39AA

Zinc transporter ZIP10 (Solute carrier family 39 member 10) (Zrt- and Irt-like protein 10) (ZIP-10)

Entry name S39AA	UniProt ID Q9ULF5	EVMP confidence score 0.50
Supporting publications (n) 9	Transmembrane count 7	Protein classification Essential proteinsMetabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Zinc transporter ZIP10 (Solute carrier family 39 member 10) (Zrt- and Irt-like protein 10) (ZIP-10)

Protein Class (5)

Essential proteinsMetabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function (2)

Transporters:Electrochemical Potential-driven transporters
Predicted intracellular proteins

Transmembrane

411..431; Helical; 438..458; Helical; 495..515; Helical; 687..707; Helical; 732..752; Helical; 759..779; Helical; 801..821; Helical

Transmembrane Count

Ensembl

ENSG00000196950

Entrez Gene Symbol

SLC39A10

Gene Synonym (3)

DKFZp564L2123FLJ90515KIAA1265

Gene Description

Solute carrier family 39 member 10

Chromosome

Position

195575977-195737702

Supporting publications (n)

EVMP confidence score

0.50

Function & Pathway7

Protein Function (2)

Transporters:Electrochemical Potential-driven transporters
Predicted intracellular proteins

Cellular Component (2)

Molecular Function (3)

Biological Process (3)

KEGG (2)

Reactome (5)

Mediation Categories (2)

Fusion and delivery mediationImmune mediation

Relations & Evidence26

Ligand-Receptor Signaling (24)

24 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
receptor	receptor	scConnect	No	Yes	No	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	ARL6IP6 FRMD5 GTPBP3 SCARF2 SLC39A10 SPINT2 TRIM59	O43291 Q7Z6J6 Q8IWR1 Q8N6S5 Q969Y2 Q96GP6 Q9ULF5	0:0:0:0:0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western blotting	1	36064647

Sequence, Structure & Domains9

Sequences

Length

831

Mass

94,132

Sequence

MKVHMHTKFCLICLLTFIFHHCNHCHEEHDHGPEALHRQHRGMTELEPSKFSKQAAENEKKYYIEKLFERYGENGRLSFFGLEKLLTNLGLGERKVVEINHEDLGHDHVSHLDILAVQEGKHFHSHNHQHSHNHLNSENQTVTSVSTKRNHKCDPEKETVEVSVKSDDKHMHDHNHRLRHHHRLHHHLDHNNTHHFHNDSITPSERGEPSNEPSTETNKTQEQSDVKLPKGKRKKKGRKSNENSEVITPGFPPNHDQGEQYEHNRVHKPDRVHNPGHSHVHLPERNGHDPGRGHQDLDPDNEGELRHTRKREAPHVKNNAIISLRKDLNEDDHHHECLNVTQLLKYYGHGANSPISTDLFTYLCPALLYQIDSRLCIEHFDKLLVEDINKDKNLVPEDEANIGASAWICGIISITVISLLSLLGVILVPIINQGCFKFLLTFLVALAVGTMSGDALLHLLPHSQGGHDHSHQHAHGHGHSHGHESNKFLEEYDAVLKGLVALGGIYLLFIIEHCIRMFKHYKQQRGKQKWFMKQNTEESTIGRKLSDHKLNNTPDSDWLQLKPLAGTDDSVVSEDRLNETELTDLEGQQESPPKNYLCIEEEKIIDHSHSDGLHTIHEHDLHAAAHNHHGENKTVLRKHNHQWHHKHSHHSHGPCHSGSDLKETGIANIAWMVIMGDGIHNFSDGLAIGAAFSAGLTGGISTSIAVFCHELPHELGDFAVLLKAGMTVKQAIVYNLLSAMMAYIGMLIGTAVGQYANNITLWIFAVTAGMFLYVALVDMLPEMLHGDGDNEEHGFCPVGQFILQNLGLLFGFAIMLVIALYEDKIVFDIQF

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9ULF5-1; Sequence=Displayed; Name=2; IsoId=Q9ULF5-2; Sequence=VSP_055991

Alternative Sequence

1..450; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias

138..147; Polar residues; 152..171; Basic and acidic residues; 172..188; Basic residues; 189..198; Basic and acidic residues; 211..221; Polar residues; 229..238; Basic residues; 256..273; Basic and acidic residues; 281..315; Basic and acidic residues

Region

126..318; Disordered; 464..484; Disordered

Protein Families

ZIP transporter (TC 2.A.5) family

Sequence Similarities

Belongs to the ZIP transporter (TC 2.A.5) family.

Clinical Relevance4

Antibody (3)

HPA036512 HPA036513 HPA066087

Interaction Protein (2)

ENSG00000008513ENSG00000103742

Interaction Count

Interaction Dataset

biogrid_bioplex

Supporting Publications9

PMID	Title	Abstract
27894104	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	No abstract available
28986585	Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics.	No abstract available
32089743	Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism.	No abstract available
33035814	Knockout of PRDX6 induces mitochondrial dysfunction and cell cycle arrest at G2/M in HepG2 hepatocarcinoma cells.	No abstract available
34817906	Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform.	No abstract available
35611462	Extracellular vesicles expressing CEACAM proteins in the urine of bladder cancer patients.	No abstract available
37786918	Rapid and in-depth proteomic profiling of small extracellular vesicles for ultralow samples.	No abstract available
38321535	Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles.	No abstract available
40748658	Exosomes released from senescent cells and circulatory exosomes isolated from human plasma reveal aging-associated proteomic and lipid signatures.	No abstract available