Protein detail
ASAP1
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP)
Protein symbol ASAP1 | UniProt ID | EVMP score 0.63 |
Frequency 7 | Transmembrane count | Protein classification Predicted intracellular proteins |
Basic Information
Protein Names
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
CENTB4DDEF1KIAA1249PAPZG14P
Gene Description
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
Chromosome
8
Position
130052104-130443674
Frequency
7
EVMP Score
0.63
Fluorescence & Localization
Tissue Specificadipose tissueCell SpecificB-cellsSingle-Nuclei Brain SpecificfibroblastBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
Canonical Pathways
- M56 Pid lpa4 pathway
- M8 Pid endothelin pathway
- M15 Pid lysophospholipid pathway
Mediation Categories
Fusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
3 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ASAP1 | PTK2B | Q14289 | Y | 767 | phosphorylation | SIGNOR | SIGNOR:12771146 |
| ASAP1 | PTK2B | Q14289 | Y | 323 | phosphorylation | SIGNOR | SIGNOR:12771146 |
| ASAP1 | SRC | P12931 | Y | 767 | phosphorylation | REACH_ProtMapperSparser_ProtMapperProtMapper | ProtMapper:24957964 |
Ligand-Receptor Signaling
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| FAK2 | Q14289 | ASAP1 | Q9ULH1 | Yes | Yes | Yes | WangAdhesomeiPTMnetSIGNORProtMapperHPRDKEAphosphoELM_KEASIGNOR_ProtMapper | KEA:12771146ProtMapper:12771146HPRD:12771146Adhesome:12771146SIGNOR:12771146 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometryMass spectrometry [LTQ-FT Ultra]Mass spectrometry [QTOF]R Sequencing | 1 | 38037300 |
Sequence, Structure & Domains
Sequences
Length
1,129
Mass
125,498
Sequence
MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLLEEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVKFSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKIEKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNLIKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLDQKEDSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTISHATSNRQPAKLNLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGENSLEDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPGQELGETALHLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLRSKPTVDIVNQAGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDESDDDLDDKPSPIKKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVSTSTDSPTSPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRTLSDPPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKLPQKVALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPPKPGELPPKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEVTLKSHPLDLSPNVQSRDAIQKQASEDSNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYDCQADNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=2; IsoId=Q9ULH1-1; Sequence=Displayed; Name=1; IsoId=Q9ULH1-2; Sequence=VSP_008365
Alternative Sequence
303; E -> ESRR (in isoform 1)
3D Structural Models
Turn
370..372
Helix
401..419; 1121..1123
Beta Strand
327..334; 336..338; 342..350; 353..356; 366..369; 373..377; 379..383; 385..389; 392..397; 1070..1076; 1081..1085; 1093..1098; 1101..1109; 1116..1120; 1124..1126
3D Structure
NMR spectroscopy (4); X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
713..722; Acidic residues; 723..734; Basic and acidic residues; 735..747; Polar residues; 777..788; Low complexity; 809..822; Low complexity; 862..872; Polar residues; 876..889; Low complexity; 932..943; Pro residues; 956..966; Pro residues; 1001..1018; Polar residues
Repeat
600..632; ANK 1; 636..665; ANK 2
Zinc Finger
454..477; C4-type
Domain (CC)
The PH domain most probably contributes to the phosphoinositide-dependent regulation of ADP ribosylation factors.
Domain (FT)
324..416; PH; 439..560; Arf-GAP; 1067..1129; SH3
Region
713..760; Disordered; 776..1062; Disordered