Protein detail
GRID1
Glutamate receptor ionotropic, delta-1 (GluD1) (GluR delta-1 subunit)
Protein symbol GRID1 | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 3 | Protein classification |
Basic Information
Protein Names
Glutamate receptor ionotropic, delta-1 (GluD1) (GluR delta-1 subunit)
Protein Function
Transporters:Transporter channels and pores
Transmembrane
563..583; Helical; 638..658; Helical; 831..851; Helical
Transmembrane Count
3
Ensembl
Entrez Gene Symbol
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Cell SpecificEsophageal apical cellsSingle-Nuclei Brain SpecificoligodendrocyteBlood Cell SpecificbasophilBlood Lineage SpecificgranulocytesSecretome LocationIntracellular and membraneSecretome FunctionCell adhesion
Function & Pathway
Protein Function
Transporters:Transporter channels and pores
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Clinical-translation mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
27 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| glutamate | receptor | Almen2009 | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| transporter | transporter | Surfaceome | No | Yes | No | Yes | No |
| glutamate | transporter | Surfaceome | No | Yes | No | Yes | No |
| channels | transporter | Surfaceome | No | Yes | No | Yes | No |
| ion_channel | ion_channel | DGIdb | No | Yes | No | Yes | No |
| ion_channel | ion_channel | Almen2009 | No | Yes | No | Yes | No |
| ligand_gated | ion_channel | Almen2009 | No | Yes | No | Yes | No |
| ligand_gated | ion_channel | Surfaceome | No | Yes | No | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ANKS1AARHGAP42DEF6GRID1TNS3 | A6NI28Q68CZ2Q92625Q9H4E7Q9ULK0 | 0:0:0:0:0 | hu.MAP2 | |||
| ARHGAP42DEF6GRID1TNS3 | A6NI28Q68CZ2Q9H4E7Q9ULK0 | 0:0:0:0 | hu.MAP2 | |||
| ANKS1AARHGAP42DEF6GRID1 | A6NI28Q92625Q9H4E7Q9ULK0 | 0:0:0:0 | hu.MAP | |||
| GRID1 | Q9ULK0 | 6 | PDB | PDB:8bljPDB:8bn2PDB:8bn5 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 27863537 |
Sequence, Structure & Domains
Sequences
Length
1,009
Mass
112,131
Sequence
MEALTLWLLPWICQCVSVRADSIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQEACDLMTQGILALVTSTGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACHLNPSPDGEAYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQKVDKNISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEAVETNLASKDSHWVFVNEEISDPEILDLVHSALGRMTVVRQIFPSAKDNQKCTRNNHRISSLLCDPQEGYLQMLQISNLYLYDSVLMLANAFHRKLEDRKWHSMASLNCIRKSTKPWNGGRSMLDTIKKGHITGLTGVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWDSEKGLNGSLQERPMGSRLQGLTLKVVTVLEEPFVMVAENILGQPKRYKGFSIDVLDALAKALGFKYEIYQAPDGRYGHQLHNTSWNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYSVGILIKKPEEKISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVRAQSAAQPRPSASATLHSAIWIVYGAFVQQGGESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQVEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGADNCVSSPSEGIRKAKKGNYAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHMGRCDLTSHASAQADGKSLKLHSFAGVFCILAIGLLLACLVAALELWWNSNRCHQETPKEDKEVNLEQVHRRMNSLMDEDIAHKQISPASIELSALEMGGLAPTQTLEPTREYQNTQLSVSTFLPEQSSHGTSRTLSSGPSSNLPLPLSSSATMPSMQCKHRSPNGGLFRQSPVKTPIPMSFQPVPGGVLPEALDTSHGTSI
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9ULK0-1; Sequence=Displayed; Name=2; IsoId=Q9ULK0-2; Sequence=VSP_057019
Alternative Sequence
1..429; Missing (in isoform 2)
3D Structural Models
Turn
447..449; 713..720
Helix
466..478; 503..509; 524..527; 668..672; 686..695; 704..712; 725..734; 743..751; 780..793; 796..804
Beta Strand
438..443; 450..454; 462..465; 481..486; 514..516; 530..532; 536..539; 541..547; 678..680; 700..702; 722..724; 735..742; 758..761; 768..770; 807..810
3D Structure
X-ray crystallography (3)
Domain & Motif Annotations
Compositional Bias
930..942; Polar residues; 943..954; Low complexity
Region
21..436; Interaction with CBLN1; 930..954; Disordered
Protein Families
- Glutamate-gated ion channel (TC 1.A.10.1) family
- GRID1 subfamily
Sequence Similarities
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRID1 subfamily.
Clinical Relevance
Drug Targets
Clinical trial targetSuccessful targetDiscontinued targetLiterature-reported target
Drugs