Protein detail

GRID1

Glutamate receptor ionotropic, delta-1 (GluD1) (GluR delta-1 subunit)

Entry name GRID1	UniProt ID Q9ULK0	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count 3	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

Glutamate receptor ionotropic, delta-1 (GluD1) (GluR delta-1 subunit)

Protein Function

Transporters:Transporter channels and pores

Transmembrane

563..583; Helical; 638..658; Helical; 831..851; Helical

Transmembrane Count

Ensembl

ENSG00000182771

Entrez Gene Symbol

GRID1

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization6

Cell SpecificEsophageal apical cellsSingle-Nuclei Brain SpecificoligodendrocyteBlood Cell SpecificbasophilBlood Lineage SpecificgranulocytesSecretome LocationIntracellular and membraneSecretome FunctionCell adhesion

Function & Pathway6

Protein Function

Transporters:Transporter channels and pores

Cellular Component (5)

Molecular Function (4)

Biological Process (3)

KEGG

hsa04080 Neuroactive ligand-receptor interaction

Mediation Categories (2)

Clinical-translation mediationReceptor-signaling mediation

Relations & Evidence32

Ligand-Receptor Signaling (27)

27 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
glutamate	receptor	Almen2009	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
transporter	transporter	Surfaceome	No	Yes	No	Yes	No
glutamate	transporter	Surfaceome	No	Yes	No	Yes	No
channels	transporter	Surfaceome	No	Yes	No	Yes	No
ion_channel	ion_channel	DGIdb	No	Yes	No	Yes	No
ion_channel	ion_channel	Almen2009	No	Yes	No	Yes	No
ligand_gated	ion_channel	Almen2009	No	Yes	No	Yes	No
ligand_gated	ion_channel	Surfaceome	No	Yes	No	Yes	No

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Protein Complex Composition (4)

4 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
ANKS1A ARHGAP42 DEF6 GRID1 TNS3	A6NI28 Q68CZ2 Q92625 Q9H4E7 Q9ULK0	0:0:0:0:0	hu.MAP2
ARHGAP42 DEF6 GRID1 TNS3	A6NI28 Q68CZ2 Q9H4E7 Q9ULK0	0:0:0:0	hu.MAP2
ANKS1A ARHGAP42 DEF6 GRID1	A6NI28 Q92625 Q9H4E7 Q9ULK0	0:0:0:0	hu.MAP
GRID1	Q9ULK0	6	PDB	PDB:8bljPDB:8bn2PDB:8bn5

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	27863537

Sequence, Structure & Domains13

Sequences

Length

1,009

Mass

112,131

Sequence

MEALTLWLLPWICQCVSVRADSIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQEACDLMTQGILALVTSTGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACHLNPSPDGEAYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQKVDKNISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEAVETNLASKDSHWVFVNEEISDPEILDLVHSALGRMTVVRQIFPSAKDNQKCTRNNHRISSLLCDPQEGYLQMLQISNLYLYDSVLMLANAFHRKLEDRKWHSMASLNCIRKSTKPWNGGRSMLDTIKKGHITGLTGVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWDSEKGLNGSLQERPMGSRLQGLTLKVVTVLEEPFVMVAENILGQPKRYKGFSIDVLDALAKALGFKYEIYQAPDGRYGHQLHNTSWNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYSVGILIKKPEEKISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVRAQSAAQPRPSASATLHSAIWIVYGAFVQQGGESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQVEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGADNCVSSPSEGIRKAKKGNYAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHMGRCDLTSHASAQADGKSLKLHSFAGVFCILAIGLLLACLVAALELWWNSNRCHQETPKEDKEVNLEQVHRRMNSLMDEDIAHKQISPASIELSALEMGGLAPTQTLEPTREYQNTQLSVSTFLPEQSSHGTSRTLSSGPSSNLPLPLSSSATMPSMQCKHRSPNGGLFRQSPVKTPIPMSFQPVPGGVLPEALDTSHGTSI

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9ULK0-1; Sequence=Displayed; Name=2; IsoId=Q9ULK0-2; Sequence=VSP_057019

Alternative Sequence

1..429; Missing (in isoform 2)

3D Structural Models

Turn

447..449; 713..720

Helix

466..478; 503..509; 524..527; 668..672; 686..695; 704..712; 725..734; 743..751; 780..793; 796..804

Beta Strand

438..443; 450..454; 462..465; 481..486; 514..516; 530..532; 536..539; 541..547; 678..680; 700..702; 722..724; 735..742; 758..761; 768..770; 807..810

3D Structure

X-ray crystallography (3)

Domain & Motif Annotations

Compositional Bias

930..942; Polar residues; 943..954; Low complexity

Region

21..436; Interaction with CBLN1; 930..954; Disordered

Protein Families (2)

Glutamate-gated ion channel (TC 1.A.10.1) family
GRID1 subfamily

Sequence Similarities

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRID1 subfamily.

Clinical Relevance2

Drug Targets (4)

Clinical trial targetSuccessful targetDiscontinued targetLiterature-reported target

Drugs

O-F-AMIDINE

Supporting Publications1

PMID	Title	Abstract
37438638	Extracellular Vesicles Play a Central Role in Cerebral Venous Disease-Associated Brain Atrophy.	No abstract available