Protein detail
TBC24
TBC1 domain family member 24
Entry name TBC24 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
TBC1 domain family member 24
Protein Class
Disease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Epilepsy
- Disease related genes
- Human disease related genes:Congenital malformations:Other congenital malformations
- Human disease related genes:Nervous system diseases:Ear disease
Ensembl
Entrez Gene Symbol
Gene Synonym
DFNA65DFNB86KIAA1171TLDC6
Gene Description
TBC1 domain family member 24
Chromosome
16
Position
2475051-2509560
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificintestineCell SpecificAlveolar cells type 1Single-Nuclei Brain Specificependymal cellBlood Cell Specificplasmacytoid DCBlood Lineage Specificdendritic cells
Function & Pathway
Protein Function
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Epilepsy
- Disease related genes
- Human disease related genes:Congenital malformations:Other congenital malformations
- Human disease related genes:Nervous system diseases:Ear disease
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
6 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CHMP1BCHMP4BCHMP4CMOCOSTBC1D24 | Q7LBR1Q96CF2Q96EN8Q9H444Q9ULP9 | 0:0:0:0:0 | hu.MAP | |||
| CHMP1BCHMP4CMOCOSTBC1D24 | Q7LBR1Q96CF2Q96EN8Q9ULP9 | 0:0:0:0 | hu.MAP | |||
| ATP6V0D2C1orf21TBC1D24TMEM185ATMEM185B | Q8N8Y2Q8NFB2Q9H246Q9H7F4Q9ULP9 | 0:0:0:0:0 | hu.MAP | |||
| C1orf21CSNK1G1TBC1D24TMEM185ATMEM185B | Q8NFB2Q9H246Q9H7F4Q9HCP0Q9ULP9 | 0:0:0:0:0 | hu.MAP |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 30646616 |
Sequence, Structure & Domains
Sequences
Length
559
Mass
62,919
Sequence
MDSPGYNCFVDKDKMDAAIQDLGPKELSCTELQELKQLARQGYWAQSHALRGKVYQRLIRDIPCRTVTPDASVYSDIVGKIVGKHSSSCLPLPEFVDNTQVPSYCLNARGEGAVRKILLCLANQFPDISFCPALPAVVALLLHYSIDEAECFEKACRILACNDPGRRLIDQSFLAFESSCMTFGDLVNKYCQAAHKLMVAVSEDVLQVYADWQRWLFGELPLCYFARVFDVFLVEGYKVLYRVALAILKFFHKVRAGQPLESDSVKQDIRTFVRDIAKTVSPEKLLEKAFAIRLFSRKEIQLLQMANEKALKQKGITVKQKSVSLSKRQFVHLAVHAENFRSEIVSVREMRDIWSWVPERFALCQPLLLFSSLQHGYSLARFYFQCEGHEPTLLLIKTTQKEVCGAYLSTDWSERNKFGGKLGFFGTGECFVFRLQPEVQRYEWVVIKHPELTKPPPLMAAEPTAPLSHSASSDPADRLSPFLAARHFNLPSKTESMFMAGGSDCLIVGGGGGQALYIDGDLNRGRTSHCDTFNNQPLCSENFLIAAVEAWGFQDPDTQ
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9ULP9-1; Sequence=Displayed; Name=2; IsoId=Q9ULP9-2; Sequence=VSP_025701
Alternative Sequence
322..327; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Domain (CC)
The Rab-GAP TBC domain is essential for phosphatidylinositol binding.
Domain (FT)
47..262; Rab-GAP TBC; 343..554; TLDc