Protein detail

MYO5B

Unconventional myosin-Vb

Entry name MYO5B	UniProt ID Q9ULV0	EVMP confidence score 0.38
Supporting publications (n) 4	Transmembrane count	Protein classification Disease related genesHuman disease related genesMetabolic proteinsPlasma proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Unconventional myosin-Vb

Protein Class (5)

Disease related genesHuman disease related genesMetabolic proteinsPlasma proteinsPredicted intracellular proteins

Protein Function (4)

Disease related genes
Human disease related genes:Digestive system diseases:Liver diseases
Human disease related genes:Digestive system diseases:Gastrointestinal diseases
Predicted intracellular proteins

Ensembl

ENSG00000167306

Entrez Gene Symbol

MYO5B

Gene Synonym

KIAA1119

Gene Description

Myosin VB

Chromosome

Position

49822789-50195164

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization4

Tissue SpecificretinaCell SpecificCone photoreceptor cellsSingle-Nuclei Brain Specificcentral nervous system macrophage

Function & Pathway7

Protein Function (4)

Disease related genes
Human disease related genes:Digestive system diseases:Liver diseases
Human disease related genes:Digestive system diseases:Gastrointestinal diseases
Predicted intracellular proteins

Cellular Component (10)

Molecular Function (6)

Biological Process (3)

KEGG (2)

Reactome (3)

Mediation Categories (2)

Fusion and delivery mediationMetabolism mediation

Relations & Evidence14

Ligand-Receptor Signaling (5)

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (8)

8 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
CART complex	ACTN4 HGS MYO5B TRIM3	O14964 O43707 O75382 Q9ULV0	0:0:0:0	CORUM	CORUM:6083	15772161
HT_SC_Cluster310	MYO5A MYO5B MYO5C MYO6 UNC45A UNC45B	Q8IWX7 Q9H3U1 Q9NQX4 Q9ULV0 Q9UM54 Q9Y4I1	1:1:1:1:1:1	Compleat	Compleat:HC1343
myosin-Vb-Rab11-FIP2-Rab11a complex	MYO5B RAB11A RAB11FIP2	P62491 Q7L804 Q9ULV0	0:0:0	CORUM	CORUM:6253	12393859
	MYO5B NAT14 PEX19	P40855 Q8WUY8 Q9ULV0	0:0:0	hu.MAP2
	MYO5B PEX19	P40855 Q9ULV0	0:0	hu.MAP2
	MYO5B RAB11A	P62491 Q9ULV0	2:2	PDB	PDB:4lwzPDB:4lx0
	ATAD3C DKK3 MYO19 MYO5A MYO5B	Q5T2N8 Q96H55 Q9UBP4 Q9ULV0 Q9Y4I1	0:0:0:0:0	hu.MAP2
	MYO19 MYO5A MYO5B MYO5C MYO6	Q96H55 Q9NQX4 Q9ULV0 Q9UM54 Q9Y4I1	0:0:0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western blotting	1	36064647

Sequence, Structure & Domains15

Sequences

Length

1,848

Mass

213,672

Sequence

MSVGELYSQCTRVWIPDPDEVWRSAELTKDYKEGDKSLQLRLEDETILEYPIDVQRNQLPFLRNPDILVGENDLTALSYLHEPAVLHNLKVRFLESNHIYTYCGIVLVAINPYEQLPIYGQDVIYTYSGQNMGDMDPHIFAVAEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFATVGGSASETNIEEKVLASSPIMEAIGNAKTTRNDNSSRFGKYIQIGFDKRYHIIGANMRTYLLEKSRVVFQADDERNYHIFYQLCAAAGLPEFKELALTSAEDFFYTSQGGDTSIEGVDDAEDFEKTRQAFTLLGVKESHQMSIFKIIASILHLGSVAIQAERDGDSCSISPQDVYLSNFCRLLGVEHSQMEHWLCHRKLVTTSETYVKTMSLQQVINARNALAKHIYAQLFGWIVEHINKALHTSLKQHSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNSHVFKLEQEEYMKEQIPWTLIDFYDNQPCIDLIEAKLGILDLLDEECKVPKGTDQNWAQKLYDRHSSSQHFQKPRMSNTAFIIVHFADKVEYLSDGFLEKNRDTVYEEQINILKASKFPLVADLFHDDKDPVPATTPGKGSSSKISVRSARPPMKVSNKEHKKTVGHQFRTSLHLLMETLNATTPHYVRCIKPNDEKLPFHFDPKRAVQQLRACGVLETIRISAAGYPSRWAYHDFFNRYRVLVKKRELANTDKKAICRSVLENLIKDPDKFQFGRTKIFFRAGQVAYLEKLRADKFRTATIMIQKTVRGWLQKVKYHRLKGATLTLQRYCRGHLARRLAEHLRRIRAAVVLQKHYRMQRARQAYQRVRRAAVVIQAFTRAMFVRRTYRQVLMEHKATTIQKHVRGWMARRHFQRLRDAAIVIQCAFRMLKARRELKALRIEARSAEHLKRLNVGMENKVVQLQRKIDEQNKEFKTLSEQLSVTTSTYTMEVERLKKELVHYQQSPGEDTSLRLQEEVESLRTELQRAHSERKILEDAHSREKDELRKRVADLEQENALLKDEKEQLNNQILCQSKDEFAQNSVKENLMKKELEEERSRYQNLVKEYSQLEQRYDNLRDEMTIIKQTPGHRRNPSNQSSLESDSNYPSISTSEIGDTEDALQQVEEIGLEKAAMDMTVFLKLQKRVRELEQERKKLQVQLEKREQQDSKKVQAEPPQTDIDLDPNADLAYNSLKRQELESENKKLKNDLNELRKAVADQATQNNSSHGSPDSYSLLLNQLKLAHEELEVRKEEVLILRTQIVSADQRRLAGRNAEPNINARSSWPNSEKHVDQEDAIEAYHGVCQTNSKTEDWGYLNEDGELGLAYQGLKQVARLLEAQLQAQSLEHEEEVEHLKAQLEALKEEMDKQQQTFCQTLLLSPEAQVEFGVQQEISRLTNENLDLKELVEKLEKNERKLKKQLKIYMKKAQDLEAAQALAQSERKRHELNRQVTVQRKEKDFQGMLEYHKEDEALLIRNLVTDLKPQMLSGTVPCLPAYILYMCIRHADYTNDDLKVHSLLTSTINGIKKVLKKHNDDFEMTSFWLSNTCRLLHCLKQYSGDEGFMTQNTAKQNEHCLKNFDLTEYRQVLSDLSIQIYQQLIKIAEGVLQPMIVSAMLENESIQGLSGVKPTGYRKRSSSMADGDNSYCLEAIIRQMNAFHTVMCDQGLDPEIILQVFKQLFYMINAVTLNNLLLRKDVCSWSTGMQLRYNISQLEEWLRGRNLHQSGAVQTMEPLIQAAQLLQLKKKTQEDAEAICSLCTSLSTQQIVKILNLYTPLNEFEERVTVAFIRTIQAQLQERNDPQQLLLDAKHMFPVLFPFNPSSLTMDSIHIPACLNLEFLNEV

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9ULV0-1; Sequence=Displayed; Name=2; IsoId=Q9ULV0-2; Sequence=VSP_056199, VSP_056200; Name=3; IsoId=Q9ULV0-3; Sequence=VSP_056198

Alternative Sequence

1..1430; Missing (in isoform 3); 1..859; Missing (in isoform 2); 1315..1340; Missing (in isoform 2)

3D Structural Models

Turn

1485..1487; 1539..1541; 1801..1803

Helix

1474..1476; 1477..1484; 1490..1493; 1500..1514; 1518..1538; 1543..1562; 1567..1569; 1575..1578; 1588..1613; 1614..1616; 1617..1622; 1654..1670; 1675..1699; 1701..1703; 1706..1725; 1729..1731; 1733..1736; 1738..1746; 1754..1763; 1769..1778; 1791..1800; 1831..1833; 1838..1840

Beta Strand

1468..1471; 1845..1848

3D Structure

X-ray crystallography (4)

Domain & Motif Annotations

Compositional Bias

1101..1121; Polar residues; 1166..1179; Basic and acidic residues

Coiled Coil

899..1266; 1341..1471

Domain (FT)

8..60; Myosin N-terminal SH3-like; 69..761; Myosin motor; 769..798; IQ 1; 792..821; IQ 2; 817..848; IQ 3; 840..869; IQ 4; 865..896; IQ 5; 888..917; IQ 6; 1526..1803; Dilute

Region

21..40; Requires for interaction with LIMA1; 596..630; Disordered; 640..662; Actin-binding; 1093..1123; Disordered; 1166..1192; Disordered

Protein Families (2)

TRAFAC class myosin-kinesin ATPase superfamily
Myosin family

Sequence Similarities

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

Clinical Relevance2

Disease Involvement (2)

Disease variantIntrahepatic cholestasis

Antibody (3)

HPA040593 HPA040902 HPA069773

Supporting Publications4

PMID	Title	Abstract
38037300	Proteomic profiling of paired human liver homogenate and tissue derived extracellular vesicles.	No abstract available
38576002	Therapy-induced senescent tumor cell-derived extracellular vesicles promote colorectal cancer progression through SERPINE1-mediated NF-κB p65 nuclear translocation.	No abstract available
38871114	Proteomic analysis of endothelial cells and extracellular vesicles in response to indoxyl sulfate: Mechanisms of endothelial dysfunction in chronic kidney disease.	No abstract available
39996590	Surface Double Dendritic Magnetic Microfibrils for Rapid Isolation and Proteomic Profiling of Extracellular Vesicles from Microliters of Biofluids.	No abstract available