Protein detail
FZD4
Frizzled-4 (Fz-4) (hFz4) (FzE4) (CD antigen CD344)
Protein symbol FZD4 | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count 7 | Protein classification CD markersDisease related genesG-protein coupled receptorsHuman disease related genesPotential drug targetsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Frizzled-4 (Fz-4) (hFz4) (FzE4) (CD antigen CD344)
Protein Class
CD markersDisease related genesG-protein coupled receptorsHuman disease related genesPotential drug targetsPredicted membrane proteins
Protein Function
- CD markers
- Potential drug targets
- G-protein coupled receptors:GPCRs excl olfactory receptors
- Disease related genes
- G-protein coupled receptors:Family fz/smo receptors
- Human disease related genes:Nervous system diseases:Eye disease
Transmembrane
213..243; Helical; Name=1; 250..275; Helical; Name=2; 300..333; Helical; Name=3; 337..365; Helical; Name=4; 384..418; Helical; Name=5; 432..460; Helical; Name=6; 474..495; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym
CD344EVR1
Gene Description
Frizzled class receptor 4
Chromosome
11
Position
86945679-86955395
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificadrenal glandCell SpecificAlveolar cells type 1Single-Nuclei Brain Specificendothelial cellBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function
- CD markers
- Potential drug targets
- G-protein coupled receptors:GPCRs excl olfactory receptors
- Disease related genes
- G-protein coupled receptors:Family fz/smo receptors
- Human disease related genes:Nervous system diseases:Eye disease
Cellular Component
Molecular Function
- GO:0001540 amyloid-beta binding
- GO:0004896 cytokine receptor activity
- GO:0004930 G protein-coupled receptor activity
- GO:0005515 protein binding
- GO:0017147 Wnt-protein binding
- GO:0019955 cytokine binding
- GO:0030165 PDZ domain binding
- GO:0031625 ubiquitin protein ligase binding
- GO:0038023 signaling receptor activity
- GO:0042803 protein homodimerization activity
- GO:0042813 Wnt receptor activity
- GO:0044877 protein-containing complex binding
- GO:0046982 protein heterodimerization activity
Biological Process
KEGG
- hsa04150 mTOR signaling pathway
- KEGG:hsa04310 Wnt signaling pathway
- KEGG:hsa04390 Hippo signaling pathway
- KEGG:hsa04519 Cadherin signaling
- KEGG:hsa04550 Signaling pathways regulating pluripotency of stem cells
- KEGG:hsa04916 Melanogenesis
- KEGG:hsa04934 Cushing syndrome
- KEGG:hsa05010 Alzheimer disease
- KEGG:hsa05022 Pathways of neurodegeneration - multiple diseases
- KEGG:hsa05165 Human papillomavirus infection
- KEGG:hsa05200 Pathways in cancer
- KEGG:hsa05205 Proteoglycans in cancer
- KEGG:hsa05217 Basal cell carcinoma
- KEGG:hsa05224 Breast cancer
- KEGG:hsa05225 Hepatocellular carcinoma
- KEGG:hsa05226 Gastric cancer
Reactome
- R-hsa-4608870 asymmetric localization of pcp proteins
- R-hsa-3858494 beta catenin independent wnt signaling
- R-hsa-4086398 ca2 pathway
- R-hsa-8856825 cargo recognition for clathrin mediated endocytosis
- R-hsa-373080 class b 2 secretin family receptors
- R-hsa-8856828 clathrin mediated endocytosis
- R-hsa-5663202 diseases of signal transduction by growth factor receptors and second messengers
- R-hsa-500792 gpcr ligand binding
- R-hsa-199991 membrane trafficking
- R-hsa-4086400 pcp ce pathway
- R-hsa-4641263 regulation of fzd by ubiquitination
- R-hsa-372790 signaling by gpcr
- R-hsa-5340588 signaling by rnf43 mutants
- R-hsa-195721 signaling by wnt
- R-hsa-4791275 signaling by wnt in cancer
- R-hsa-201681 tcf dependent signaling in response to wnt
- R-hsa-5653656 vesicle mediated transport
- R-hsa-5099900 wnt5a dependent internalization of fzd4
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
60 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| class_f_frizzled_protein_frizzled | receptor | GPCRdb | No | Yes | No | Yes | No |
| wnt_pathway | receptor | ICELLNET | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| extracellular | extracellular | HPMR | No | No | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| matrix_adhesion | matrix_adhesion | Cellinker | No | Yes | No | Yes | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | Yes | No |
Regulatory Interaction Network
9 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| NDP | Q00604 | FZD4 | Q9ULV1 | Yes | Yes | No | iTALKHINTSignaLink3InnateDBHPMR_talklrInnateDB_SignaLink3talklrRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbBioGRIDBaccin2019CellinkerEMBRACECellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020SPIKE_LCLRdbSPIKE | LRdb:15035989connectomeDB2020:15035989SignaLink3:24186977InnateDB:21856951Cellinker:15035989SignaLink3:21856951SPIKE_LC:20427659BioGRID:17955262Baccin2019:15035989HINT:19837033CellTalkDB:15035989SignaLink3:23180781HINT:26158506SPIKE:20427659 |
| FZD4 | Q9ULV1 | DVL2 | O14641 | Yes | Yes | No | WangNetPathSIGNORHPRDCui2007SignaLink3CancerCellMapSPIKE_LCSPIKE | SPIKE_LC:12958364HPRD:12958364SignaLink3:12958364NetPath:12958364SIGNOR:27096005SPIKE:12958364SignaLink3:23331499CancerCellMap:12958364SIGNOR:12958364 |
| WNT5A | P41221 | FZD4 | Q9ULV1 | Yes | Yes | No | iTALKSIGNORSignaLink3HPMR_talklrHPMRCellChatDBtalklrRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbBaccin2019CellinkerEMBRACECellCallCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb | connectomeDB2020:10990458LRdb:10990458Baccin2019:10990458Cellinker:10990458HPMR:10990458SignaLink3:10990458SignaLink3:23331499SIGNOR:16602827 |
| RSPO2 | Q6UXX9 | FZD4 | Q9ULV1 | Yes | No | Yes | SIGNOR | SIGNOR:22575959 |
| FZD4 | Q9ULV1 | DVL1 | O14640 | Yes | Yes | No | ELMWangSIGNOR | ELM:19388021SIGNOR:27096005 |
| FZD4 | Q9ULV1 | LRP6 | O75581 | Yes | Yes | No | WangSIGNOR | SIGNOR:18077588 |
| ZNRF3 | Q9ULT6 | FZD4 | Q9ULV1 | Yes | No | Yes | KEGG-MEDICUSSIGNOR | SIGNOR:22575959 |
| FZD4 | Q9ULV1 | DVL3 | Q92997 | Yes | Yes | No | WangSIGNOR | SIGNOR:27096005 |
| FZD4 | Q9ULV1 | LRP5 | O75197 | Yes | Yes | No | WangSIGNOR | SIGNOR:25902418 |
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
537
Mass
59,881
Sequence
MAWRGAGPSVPGAPGGVGLSLGLLLQLLLLLGPARGFGDEEERRCDPIRISMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGMCLSVKRRCEPVLKEFGFAWPESLNCSKFPPQNDHNHMCMEGPGDEEVPLPHKTPIQPGEECHSVGTNSDQYIWVKRSLNCVLKCGYDAGLYSRSAKEFTDIWMAVWASLCFISTAFTVLTFLIDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDFEEAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNLDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQKDGTKTDKLERLMVKIGVFSVLYTVPATCVIACYFYEISNWALFRYSADDSNMAVEMLKIFMSLLVGITSGMWIWSAKTLHTWQKCSNRLVNSGKVKREKRGNGWVKPGKGSETVV
3D Structural Models
Turn
186..190; 372..374
Helix
51..53; 72..79; 80..82; 83..88; 94..102; 118..134; 141..143; 145..147; 213..243; 245..247; 250..252; 253..275; 277..281; 296..298; 300..330; 337..341; 344..365; 384..390; 392..417; 432..443; 445..460; 462..467; 474..489; 492..495; 498..511
Beta Strand
45..47; 55..57; 59..61; 105..107; 110..114; 153..155; 191..194; 197..201; 205..211; 282..289; 368..370; 377..382
3D Structure
Electron microscopy (2); X-ray crystallography (9)
Domain & Motif Annotations
Motif
499..504; Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members; 535..537; PDZ-binding
Domain (CC)
Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.; DOMAIN: The FZ domain is involved in binding with Wnt ligands.
Domain (FT)
40..161; FZ
Protein Families
G-protein coupled receptor Fz/Smo family
Sequence Similarities
Belongs to the G-protein coupled receptor Fz/Smo family.