Protein detail

COR1C

Coronin-1C (Coronin-3) (hCRNN4)

Entry name COR1C	UniProt ID Q9ULV4	EVMP confidence score 0.38
Supporting publications (n)	Transmembrane count	Protein classification Plasma proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information10

Protein Names

Coronin-1C (Coronin-3) (hCRNN4)

Protein Class (2)

Plasma proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000110880

Entrez Gene Symbol

CORO1C

Gene Synonym (2)

coronin-3HCRNN4

Gene Description

Coronin 1C

Chromosome

Position

108645109-108731526

EVMP confidence score

0.38

Function & Pathway5

Protein Function

Predicted intracellular proteins

Cellular Component (12)

Page 1 of 2

Molecular Function (3)

Biological Process (3)

Mediation Categories (4)

Adhesion and uptake mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence13

Enzyme-Mediated Modification (1)

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
CORO1C	CSNK2A1	P68400	S	463	phosphorylation	SIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:22355754 SIGNOR:22355754

Ligand-Receptor Signaling (7)

7 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
CSK21	P68400	COR1C	Q9ULV4	Yes	Yes	No	iPTMnetSIGNORProtMapperELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	SIGNOR:22355754 PhosphoSite:23410663 ELM:22355754 PhosphoSite:22355754 ProtMapper:22355754

Protein Complex Composition (3)

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
CORO1C DDX1 DDX20 MOSPD2 UBC USP45	P0CG48 Q70EL2 Q8NHP6 Q92499 Q9UHI6 Q9ULV4	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7809
ACTG1 CORO1C TWF1	P63261 Q12792 Q9ULV4	0:0:0	hu.MAP2
CORO1C TWF1	Q12792 Q9ULV4	0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometryR Sequencing	6	38113368 38354507 41068253 32854315 41307968 34576246

Sequence, Structure & Domains14

Sequences

Length

474

Mass

53,249

Sequence

MRRVVRQSKFRHVFGQAVKNDQCYDDIRVSRVTWDSSFCAVNPRFVAIIIEASGGGAFLVLPLHKTGRIDKSYPTVCGHTGPVLDIDWCPHNDQVIASGSEDCTVMVWQIPENGLTLSLTEPVVILEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWNVGTGEALINLDDMHSDMIYNVSWNRNGSLICTASKDKKVRVIDPRKQEIVAEKEKAHEGARPMRAIFLADGNVFTTGFSRMSERQLALWNPKNMQEPIALHEMDTSNGVLLPFYDPDTSIIYLCGKGDSSIRYFEITDESPYVHYLNTFSSKEPQRGMGYMPKRGLDVNKCEIARFFKLHERKCEPIIMTVPRKSDLFQDDLYPDTAGPEAALEAEEWFEGKNADPILISLKHGYIPGKNRDLKVVKKNILDSKPTANKKCDLISIPKKTTDTASVQNEAKLDEILKEIKSIKDTICNQDERISKLEQQMAKIAA

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9ULV4-1; Sequence=Displayed; Name=2; Synonyms=CRN2i2; IsoId=Q9ULV4-2; Sequence=VSP_047727; Name=3; Synonyms=CRN2i3; IsoId=Q9ULV4-3; Sequence=VSP_047728

Alternative Sequence

1; M -> MRWKDTM (in isoform 2); 1; M -> MYGPGSQLGKSGNNSWAKERGCSIACQGSLTSARLHAPSIGERPLSHMRWKDTM (in isoform 3)

3D Structural Models

Turn

9..12; 160..163; 203..206; 275..278

Helix

20..22; 322..324; 327..329; 359..361; 374..378; 391..393

Beta Strand

14..17; 23..26; 39..41; 43..50; 53..62; 76..81; 83..89; 92..100; 105..109; 123..126; 133..138; 140..143; 145..150; 155..159; 164..169; 177..182; 189..193; 198..202; 207..212; 218..220; 223..226; 232..237; 243..248; 257..263; 269..274; 279..284; 290..295; 301..308; 315..319; 331..338; 340..349; 371..373

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Repeat

25..70; WD 1; 78..118; WD 2; 128..168; WD 3; 172..202; WD 4; 215..249; WD 5; 263..303; WD 6

Coiled Coil

436..474

Domain (CC)

The C-terminal coiled-coil domain is essential for cortical membrane localization and oligomerization.

Protein Families

WD repeat coronin family

Sequence Similarities

Belongs to the WD repeat coronin family.

Clinical Relevance4

Antibody

HPA041737

Interaction Protein (3)

ENSG00000102879ENSG00000143799ENSG00000172725

Interaction Count

Interaction Dataset (3)

biogrid_bioplexbiogrid_opencellintact_biogrid_opencell_bioplex