Protein detail
NOTC3
Neurogenic locus notch homolog protein 3 (Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain]
Protein symbol NOTC3 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count 1 | Protein classification Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
Basic Information
Protein Names
Neurogenic locus notch homolog protein 3 (Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain]
Protein Class
Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Predicted intracellular proteins
- Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
- Human disease related genes:Skin diseases:Skin and soft tissue diseases
- Cancer-related genes:Candidate cancer biomarkers
- Disease related genes
- Human disease related genes:Congenital malformations:Other congenital malformations
Transmembrane
1644..1664; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CADASILCASIL
Gene Description
Notch receptor 3
Chromosome
19
Position
15159038-15200995
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Cell SpecificLate spermatidsBlood Cell Specificeosinophil
Function & Pathway
Protein Function
- Predicted intracellular proteins
- Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
- Human disease related genes:Skin diseases:Skin and soft tissue diseases
- Cancer-related genes:Candidate cancer biomarkers
- Disease related genes
- Human disease related genes:Congenital malformations:Other congenital malformations
Cellular Component
Molecular Function
Biological Process
KEGG
- hsa01522 Endocrine resistance
- KEGG:hsa04330 Notch signaling pathway
- KEGG:hsa04371 Apelin signaling pathway
- KEGG:hsa04658 Th1 and Th2 cell differentiation
- KEGG:hsa04919 Thyroid hormone signaling pathway
- KEGG:hsa05165 Human papillomavirus infection
- KEGG:hsa05200 Pathways in cancer
- KEGG:hsa05206 MicroRNAs in cancer
- KEGG:hsa05224 Breast cancer
Reactome
- R-hsa-5083630 defective lfng causes scdo3
- R-hsa-3906995 diseases associated with o glycosylation of proteins
- R-hsa-3781865 diseases of glycosylation
- R-hsa-5668914 diseases of metabolism
- R-hsa-9017802 noncanonical activation of notch3
- R-hsa-9013507 notch3 activation and transmission of signal to the nucleus
- R-hsa-9013508 notch3 intracellular domain regulates transcription
- R-hsa-350054 notch hlh transcription pathway
- R-hsa-1912422 pre notch expression and processing
- R-hsa-1912420 pre notch processing in golgi
- R-hsa-1912399 pre notch processing in the endoplasmic reticulum
- R-hsa-73857 rna polymerase ii transcription
- R-hsa-157118 signaling by notch
- R-hsa-9012852 signaling by notch3
Mediation Categories
Clinical-translation mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
62 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | Yes | No |
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | UniProt_location | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | Baccin2019 | Yes | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | OmniPath | Yes | No | No | Yes | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | Yes | No |
| matrix_adhesion | matrix_adhesion | Cellinker | No | Yes | No | Yes | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | Yes | No |
Regulatory Interaction Network
11 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| COMPLEX:P49768_Q92542_Q96BI3_Q9NZ42 | NOTC3 | Q9UM47 | Yes | Yes | No | SIGNOR | SIGNOR:25610395 |
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Protein Complex Composition
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| MAML1-RBP-Jkappa-Notch3 complex | MAML1NOTCH3RBPJ | Q06330Q92585Q9UM47 | 1:1:1 | Compleat | Compleat:HC473 | 11101851 |
| MAML2-RBP-Jkappa-Notch3 complex | MAML2NOTCH3RBPJ | Q06330Q8IZL2Q9UM47 | 1:1:1 | Compleat | Compleat:HC3333 | 12370315 |
| MAML3-RBP-Jkappa-Notch3 complex | MAML3NOTCH3RBPJ | Q06330Q96JK9Q9UM47 | 1:1:1 | Compleat | Compleat:HC3576 | 12370315 |
| ANKFY1ASB8CASKIN1FBF1HIF1ANNOTCH3OTUD7BRNASELUBE3AZFP36L2 | P47974Q05086Q05823Q6GQQ9Q8TES7Q8WXD9Q9H765Q9NWT6Q9P2R3Q9UM47 | 0:0:0:0:0:0:0:0:0:0 | hu.MAP2 | |||
| NOTCH3 | Q9UM47 | 2 | PDB | PDB:4zlpPDB:5czxPDB:6xsw |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration | Mass spectrometry | 1 | 40595564 |
Sequence, Structure & Domains
Sequences
Length
2,321
Mass
243,631
Sequence
MGPGARGRRRRRRPMSPPPPPPPVRALPLLLLLAGPGAAAPPCLDGSPCANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPCGPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQAKRGDQRCDRECNSPGCGWDGGDCSLSVGDPWRQCEALQCWRLFNNSRCDPACSSPACLYDNFDCHAGGRERTCNPVYEKYCADHFADGRCDQGCNTEECGWDGLDCASEVPALLARGVLVLTVLLPPEELLRSSADFLQRLSAILRTSLRFRLDAHGQAMVFPYHRPSPGSEPRARRELAPEVIGSVVMLEIDNRLCLQSPENDHCFPDAQSAADYLGALSAVERLDFPYPLRDVRGEPLEPPEPSVPLLPLLVAGAVLLLVILVLGVMVARRKREHSTLWFPEGFSLHKDVASGHKGRREPVGQDALGMKNMAKGESLMGEVATDWMDTECPEAKRLKVEEPGMGAEEAVDCRQWTQHHLVAADIRVAPAMALTPPQGDADADGMDVNVRGPDGFTPLMLASFCGGALEPMPTEEDEADDTSASIISDLICQGAQLGARTDRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRSTDLDARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDHFANREITDHLDRLPRDVAQERLHQDIVRLLDQPSGPRSPPGPHGLGPLLCPPGAFLPGLKAAQSGSKKSRRPPGKAGLGPQGPRGRGKKLTLACPGPLADSSVTLSPVDSLDSPRPFGGPPASPGGFPLEGPYAAATATAVSLAQLGGPGRAGLGRQPPGGCVLSLGLLNPVAVPLDWARLPPPAPPGPSFLLPLAPGPQLLNPGTPVSPQERPPPYLAVPGHGEEYPAAGAHSSPPKARFLRVPSEHPYLTPSPESPEHWASPSPPSLSDWSESTPSPATATGAMATTTGALPAQPLPLSVPSSLAQAQTQLGPQPEVTPKRQVLA
3D Structural Models
Turn
1408..1410; 1415..1420; 1424..1427; 1431..1433; 1449..1451; 1457..1459; 1589..1591; 1595..1597
Helix
1392..1395; 1403..1405; 1411..1414; 1434..1437; 1444..1446; 1452..1456; 1463..1465; 1469..1471; 1472..1478; 1486..1488; 1491..1493; 1495..1498; 1521..1526; 1528..1539; 1604..1616; 1644..1656; 1658..1665
Beta Strand
1389..1391; 1398..1400; 1439..1441; 1481..1483; 1510..1519; 1541..1545; 1549..1551; 1555..1558; 1579..1587; 1598..1600; 1626..1632
3D Structure
NMR spectroscopy (1); X-ray crystallography (5)
Domain & Motif Annotations
Compositional Bias
1..14; Basic residues; 15..25; Pro residues; 2039..2053; Low complexity; 2269..2289; Low complexity; 2296..2308; Polar residues
Repeat
1387..1427; LNR 1; 1428..1458; LNR 2; 1467..1505; LNR 3; 1838..1867; ANK 1; 1871..1901; ANK 2; 1905..1934; ANK 3; 1938..1967; ANK 4; 1971..2000; ANK 5
Domain (CC)
The EGF-like domains 10 and 11 are required for binding the ligands JAG1 and DLL1..
Domain (FT)
40..77; EGF-like 1; 78..118; EGF-like 2; 119..156; EGF-like 3; 158..195; EGF-like 4; calcium-binding; 197..234; EGF-like 5; 236..272; EGF-like 6; calcium-binding; 274..312; EGF-like 7; 314..350; EGF-like 8; calcium-binding; 351..389; EGF-like 9; 391..429; EGF-like 10; calcium-binding; 431..467; EGF-like 11; calcium-binding; 469..505; EGF-like 12; calcium-binding; 507..543; EGF-like 13; calcium-binding; 545..580; EGF-like 14; calcium-binding; 582..618; EGF-like 15; calcium-binding; 620..655; EGF-like 16; calcium-binding; 657..693; EGF-like 17; calcium-binding; 695..730; EGF-like 18; 734..770; EGF-like 19; 771..808; EGF-like 20; 810..847; EGF-like 21; calcium-binding; 849..885; EGF-like 22; calcium-binding; 887..922; EGF-like 23; calcium-binding; 924..960; EGF-like 24; 962..998; EGF-like 25; 1000..1034; EGF-like 26; 1036..1082; EGF-like 27; 1084..1120; EGF-like 28; 1122..1158; EGF-like 29; calcium-binding; 1160..1203; EGF-like 30; calcium-binding; 1205..1244; EGF-like 31; 1246..1287; EGF-like 32; 1289..1325; EGF-like 33; 1335..1373; EGF-like 34
Region
1..26; Disordered; 2024..2120; Disordered; 2190..2321; Disordered
Protein Families
NOTCH family
Sequence Similarities
Belongs to the NOTCH family.
Clinical Relevance
Disease Involvement
Cancer-related genesDisease variant
Related Diseases
Biomarker
Phase 2
Interaction Protein
ENSG00000166135
Interaction Count
1
Interaction Dataset
biogrid_bioplex