Protein detail

ALK

ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)

Protein symbol ALK	UniProt ID Q9UM73	EVMP score 0.50
Frequency 1	Transmembrane count 1	Protein classification Cancer-related genesCD markersDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

Basic Information

Protein Names

ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)

Protein Class

Cancer-related genesCD markersDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

Protein Function

Human disease related genes:Cancers:Cancers of the lung and pleura
Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
Predicted intracellular proteins
ENZYME proteins:Transferases
Cancer-related genes:Mutated cancer genes
CD markers
Enzymes
Human disease related genes:Cancers:Cancers of haematopoietic and lymphoid tissues
Kinases:Tyr protein kinases
Disease related genes
FDA approved drug targets:Small molecule drugs

Transmembrane

1039..1059; Helical

Transmembrane Count

Ensembl

ENSG00000171094

Entrez Gene Symbol

ALK

Gene Synonym

ALK1CD246

Gene Description

ALK receptor tyrosine kinase

Chromosome

Position

29192774-29921586

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue Specificbone marrowCell SpecificEsophageal apical cells

Function & Pathway

Protein Function

Human disease related genes:Cancers:Cancers of the lung and pleura
Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
Predicted intracellular proteins
ENZYME proteins:Transferases
Cancer-related genes:Mutated cancer genes
CD markers
Enzymes
Human disease related genes:Cancers:Cancers of haematopoietic and lymphoid tissues
Kinases:Tyr protein kinases
Disease related genes
FDA approved drug targets:Small molecule drugs

Cellular Component

Molecular Function

KEGG

Reactome

Mediation Categories

Clinical-translation mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

3 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
ALK	HCK	P08631	Y	1,507	phosphorylation	KEA	KEA:17570479
ALK	IGF1R	P08069	Y	1,278	phosphorylation	KEA	KEA:17570479
ALK	IGF1R	P08069	Y	1,327	phosphorylation	KEA	KEA:17570479

Ligand-Receptor Signaling

49 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor_tyrosine_kinases_rtk	receptor	HPMR	No	Yes	No	Yes	No
vegf_pdgf	receptor	HPMR	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	HPMR	No	No	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
intracellular	intracellular	LOCATE	No	No	No	Yes	No
intracellular	intracellular	ComPPI	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No

Page 2 of 5Previous Next

Regulatory Interaction Network

17 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
ALK	Q9UM73	PUR9	P31939	Yes	Yes	No	Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefSIGNORiPTMnetProtMapperREACH_ProtMapperPhosphoSite_ProtMapper	ProtMapper:33520699 SIGNOR:18845790
ALK	Q9UM73	CDK9	P50750	Yes	Yes	No	SIGNOR	SIGNOR:36253486
ALK	Q9UM73	P55G	Q92569	Yes	Yes	No	SIGNOR	SIGNOR:27322022
ALK	Q9UM73	PTN11	Q06124	Yes	Yes	No	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefProtMapperKEAKinexus_KEAWangPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:18320059 PhosphoSite:17483340 PhosphoSite:34692535 PhosphoSite:19223540 PhosphoSite:11684012 PhosphoSite:12721296 PhosphoSite:8041791 PhosphoSite:32076487 PhosphoSite:12531430 PhosphoSite:34301842 PhosphoSite:15710330 KEA:12522270
ALK	Q9UM73	ELP3	Q9H9T3	Yes	No	No	PhosphoSitePhosphoSite_ProtMapperProtMapper	PhosphoSite:31341009
ALK	Q9UM73	VASP	P50552	Yes	No	No	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:18845790
ALK	Q9UM73	SRCN1	Q9C0H9	Yes	No	No	MIMPiPTMnetPhosphoSitePhosphoSite_MIMP	PhosphoSite:23383002

Page 2 of 2Previous

Protein Complex Composition

39 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
ACSL4 ACSS2 GALK2 MVD	O60488 P53602 Q01415 Q9NR19	0:0:0:0	hu.MAP
ARIH1 CUL9 EIF4E2 GALK2 UBC UBE2L3	O60573 P0CG48 P68036 Q01415 Q8IWT3 Q9Y4X5	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8391
ALKBH7 CHDH NDUFAF3 NDUFS7	O75251 Q8NE62 Q9BT30 Q9BU61	0:0:0:0	hu.MAP2
ALKBH7 CHDH NDUFAF3 NDUFAF4 NDUFS7	O75251 Q8NE62 Q9BT30 Q9BU61 Q9P032	0:0:0:0:0	hu.MAP2
ALKBH8 ATPAF2 FECH MMP2 TIMP2	P08253 P16035 P22830 Q8N5M1 Q96BT7	0:0:0:0:0	hu.MAP2
ALKBH8 FECH MMP26 TIMP2	P16035 P22830 Q96BT7 Q9NRE1	0:0:0:0	hu.MAP2
ALKAL1 LTK	P29376 Q6UXT8	2:1	PDB	PDB:7nx0
ABAT ALDH1B1 GALK2 PGM1	P30837 P36871 P80404 Q01415	0:0:0:0	hu.MAP
ALDH1B1 GALK2 PGM1	P30837 P36871 Q01415	0:0:0	hu.MAP
GALK1	P51570	4	PDB	PDB:6q3xPDB:6zfhPDB:6zgyPDB:6gr2PDB:6zgxPDB:7rclPDB:7rcmPDB:6zgzPDB:6zgvPDB:1wuuPDB:6q90PDB:6q3wPDB:6q91PDB:6qjePDB:6zh0PDB:7ozxPDB:6q8zPDB:7s4cPDB:7s49PDB:6zgw

Page 2 of 4Previous Next

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	30875722

Sequence, Structure & Domains

Sequences

Length

1,620

Mass

176,442

Sequence

MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP

3D Structural Models

Turn

705..707; 921..923; 999..1001

Helix

698..704; 718..720; 788..794; 800..807; 896..898; 907..913; 987..989; 1087..1092; 1105..1107; 1113..1115; 1158..1173; 1204..1211; 1223..1242; 1252..1254; 1272..1280; 1288..1290; 1293..1295; 1298..1303; 1308..1323; 1335..1343; 1356..1365; 1370..1372; 1376..1388; 1390..1393

Beta Strand

675..677; 680..685; 692..694; 713..715; 724..727; 730..739; 747..751; 757..765; 770..774; 782..784; 808..810; 812..814; 825..831; 834..841; 860..862; 865..867; 875..877; 890..892; 928..930; 936..938; 956..959; 963..965; 970..975; 978..984; 990..993; 995..997; 1004..1006; 1012..1014; 1016..1022; 1096..1098; 1101..1103; 1116..1124; 1126..1135; 1137..1140; 1145..1152; 1154..1156; 1182..1186; 1188..1197; 1215..1217; 1255..1258; 1260..1263; 1266..1268; 1284..1286; 1574..1576; 1582..1584

3D Structure

Electron microscopy (2); NMR spectroscopy (5); X-ray crystallography (72)

Domain & Motif Annotations

Compositional Bias

654..666; Basic and acidic residues; 1410..1419; Basic and acidic residues

Domain (CC)

The EGF-like region drives the cytokine specificity for ALKAL2..; DOMAIN: The heparin-binding region binds heparin glycosaminoglycan (PubMed:25605972, PubMed:34646012). Heparin-binding is required for ALKAL2-driven activation (PubMed:34646012).

Domain (FT)

264..427; MAM 1; 437..473; LDL-receptor class A; 478..636; MAM 2; 1116..1392; Protein kinase

Region

48..70; Heparin-binding region; 650..674; Disordered; 987..1025; EGF-like; 1408..1463; Disordered; 1514..1540; Disordered

Protein Families

Protein kinase superfamily
Tyr protein kinase family
Insulin receptor subfamily

Sequence Similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

Clinical Relevance

Disease Involvement

Cancer-related genesDisease variantFDA approved drug targetsProto-oncogene

Related Diseases

Adrenal cancer Breast cancer Colorectal cancer Diffuse large B-cell lymphoma Lung cancer Lymphoma Mature T-cell lymphoma Metastatic tumour Non-small-cell lung cancer Solid tumour/cancer

Biomarker

Phase 1; Phase 2; Approved; Investigative; Patented

Drug Targets

FDA approved drug targets

Drugs

CERITINIB X-396 CRIZOTINIB IL-10 RETASPIMYCIN HYDROCHLORIDE NIVOLUMAB NULL ALECTINIB ENTRECTINIB CENISERTIB AFATINIB PEMBROLIZUMAB DOXORUBICIN HYDROCHLORIDE ENSARTINIB CHEMBL:CHEMBL379975 TEPOTINIB CEMIPLIMAB-RWLC ZOLEDRONIC ACID ANHYDROUS APG-2449 LORLATINIB VANDETANIB RIBOCICLIB VINCRISTINE SULFATE IDASANUTLIN DACTOLISIB GEFITINIB DABRAFENIB NAVITOCLAX ATEZOLIZUMAB ALK INHIBITOR ASP3026 BRIGATINIB ALK INHIBITOR TAE684 AZD3463 TOPOTECAN HYDROCHLORIDE ERLOTINIB FORITINIB SUCCINATE GW441756X DINACICLIB TALETRECTINIB IPILIMUMAB CARBOPLATIN IFOSFAMIDE TPX-0131 TRAMETINIB DIMETHYL SULFOXIDE DOVITINIB TAK-715 TEMOZOLOMIDE PLB1003 BELIZATINIB GILTERITINIB EG5 KINESIN-RELATED MOTOR PROTEIN INHIBITOR 4SC-205 RAMUCIRUMAB JAK3 INHIBITOR II DALANTERCEPT ETOPOSIDE SELUMETINIB SHP2 INHIBITOR PF-07284892 LUMINESPIB DURVALUMAB BRENTUXIMAB VEDOTIN PAZOPANIB CISPLATIN IRINOTECAN HYDROCHLORIDE IRUPLINALKIB PD-0166285 CARBAMAZEPINE ALVOCIDIB GSK-1838705A CP-547632 PALBOCICLIB TOZASERTIB P53/HDM2 INTERACTION INHIBITOR CGM097 REPOTRECTINIB BATOPROTAFIB CYCLOPHOSPHAMIDE ANHYDROUS CONTELTINIB PEMETREXED DISODIUM JNJ-7706621 MTI-31 FULVESTRANT LINIFANIB METHOTREXATE FILGOTINIB DEXAMETHASONE MILADEMETAN RG-1530 CRENOLANIB ONALESPIB IXAZOMIB TAMATINIB ILORASERTIB HESPERADIN ALK/C-MET INHIBITOR TQ-B3139 ALK/TRK INHIBITOR TSR-011 OSIMERTINIB BEVACIZUMAB-AWWB CYTARABINE HJC0152 SARACATINIB ALECTINIB HYDROCHLORIDE ASP-3026 IMATINIB TREMELIMUMAB VENETOCLAX THZ1 CHEMBL:CHEMBL1997335 CHEMBL:CHEMBL546797 PF-562271 GANETESPIB ALK INHIBITOR NVL-655 CEDIRANIB FICONALKIB NVP-TAE 226 CEP-37440 OCTREOTIDE ACETATE SIROLIMUS

Antibody

HPA010694

Interaction Protein

ENSG00000165731

Interaction Count

Interaction Dataset

intact_biogrid