Protein detail

ALK

ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)

Protein symbol ALK	UniProt ID Q9UM73	EVMP score 0.50
Frequency 1	Transmembrane count 1	Protein classification Cancer-related genesCD markersDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

Basic Information

Protein Names

ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)

Protein Class

Cancer-related genesCD markersDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

Protein Function

Human disease related genes:Cancers:Cancers of the lung and pleura
Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
Predicted intracellular proteins
ENZYME proteins:Transferases
Cancer-related genes:Mutated cancer genes
CD markers
Enzymes
Human disease related genes:Cancers:Cancers of haematopoietic and lymphoid tissues
Kinases:Tyr protein kinases
Disease related genes
FDA approved drug targets:Small molecule drugs

Transmembrane

1039..1059; Helical

Transmembrane Count

Ensembl

ENSG00000171094

Entrez Gene Symbol

ALK

Gene Synonym

ALK1CD246

Gene Description

ALK receptor tyrosine kinase

Chromosome

Position

29192774-29921586

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue Specificbone marrowCell SpecificEsophageal apical cells

Function & Pathway

Protein Function

Human disease related genes:Cancers:Cancers of the lung and pleura
Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
Predicted intracellular proteins
ENZYME proteins:Transferases
Cancer-related genes:Mutated cancer genes
CD markers
Enzymes
Human disease related genes:Cancers:Cancers of haematopoietic and lymphoid tissues
Kinases:Tyr protein kinases
Disease related genes
FDA approved drug targets:Small molecule drugs

Cellular Component

Molecular Function

KEGG

Reactome

Mediation Categories

Clinical-translation mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

3 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
ALK	HCK	P08631	Y	1,507	phosphorylation	KEA	KEA:17570479
ALK	IGF1R	P08069	Y	1,278	phosphorylation	KEA	KEA:17570479
ALK	IGF1R	P08069	Y	1,327	phosphorylation	KEA	KEA:17570479

Ligand-Receptor Signaling

49 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellPhoneDB	No	Yes	No	Yes	No
receptor	receptor	HPMR	No	Yes	No	Yes	No
receptor	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	CellChatDB	No	Yes	No	Yes	No
receptor	receptor	CellTalkDB	No	Yes	No	Yes	No
receptor	receptor	Ramilowski2015	No	Yes	No	Yes	No
receptor	receptor	LRdb	No	Yes	No	Yes	No
receptor	receptor	Baccin2019	No	Yes	No	Yes	No
receptor	receptor	SignaLink_function	No	Yes	No	Yes	No
growth_factor	receptor	Baccin2019	No	Yes	No	Yes	No

Page 1 of 5Next

Regulatory Interaction Network

17 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PTN	P21246	ALK	Q9UM73	Yes	Yes	No	iTALKICELLNETSIGNORHINTSignaLink3DIPCellChatDBHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019Ramilowski2015CellPhoneDBHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACECellTalkDBFantom5_LRdbconnectomeDB2020SPIKE_LCLRdb	CellChatDB:28356350 Cellinker:25620911 CellChatDB:25620911 CellTalkDB:11278720 Cellinker:28356350 Cellinker:11278720 HINT:11278720 LRdb:11278720 connectomeDB2020:11278720 ICELLNET:11278720 HINT:1848244 SPIKE_LC:16713569 SignaLink3:23331499 HPRD:11278720 DIP:1848244 SignaLink3:11278720 SIGNOR:11278720 Baccin2019:11278720
ALK	Q9UM73	PLCG1	P19174	Yes	Yes	No	PhosphoPointSIGNORHPRDSignaLink3SPIKE_LC	SIGNOR:14968112 SPIKE_LC:17145710 HPRD:9174053 SignaLink3:14968112 SignaLink3:23331499 SignaLink3:11888936
ALK	Q9UM73	STAT3	P40763	Yes	Yes	No	WangBEL-Large-Corpus_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperPhosphoSite_KEAKEASignaLink3phosphoELM_KEAphosphoELMSPIKE_LCPhosphoSite_ProtMapper	KEA:8272872 SIGNOR:16084951 SPIKE_LC:17145710 KEA:12626508 KEA:9582023 phosphoELM:11850821 KEA:11940572 KEA:9083098 ProtMapper:15212693 KEA:11850821 KEA:12244095 KEA:9305919 KEA:10918587 SignaLink3:16084951 SIGNOR:14968112 KEA:8626374 KEA:15592455 SignaLink3:23331499 KEA:11350938 SIGNOR:11850821 KEA:11294897 KEA:14551213 SignaLink3:14968112 KEA:9566874 KEA:11429593 KEA:12576423
MK	P21741	ALK	Q9UM73	Yes	Yes	No	iTALKICELLNETSignaLink3HPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBaccin2019CellinkerEMBRACECellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	Cellinker:19459784 ICELLNET:12122009Baccin2019:1212200912122000LRdb:12122009 CellChatDB:19459784 SignaLink3:12122009 HPMR:12122009 HPRD:12122009 SignaLink3:23331499 connectomeDB2020:12122009 CellTalkDB:12122009
PTPRZ	P23471	ALK	Q9UM73	Yes	Yes	Yes	HPRDWangSIGNORSignaLink3	SIGNOR:17681947 SignaLink3:17681947 SignaLink3:23331499 HPRD:17681947
PTPRB	P23467	ALK	Q9UM73	Yes	Yes	Yes	SIGNORSignaLink3	SIGNOR:17681947 SignaLink3:17681947 SignaLink3:23331499
ALK	Q9UM73	SHC3	Q92529	Yes	Yes	No	SIGNORPhosphoPointHPRDSignaLink3BioGRID	HPRD:12185581 BioGRID:12185581 SignaLink3:12185581 SignaLink3:23331499 SIGNOR:12185581
ALK	Q9UM73	SHC1	P29353	Yes	Yes	No	PhosphoPointSIGNORHPRDSignaLink3SPIKE_LC	HPRD:9174053 SignaLink3:12185581 SignaLink3:23331499 SPIKE_LC:16713569 SIGNOR:12185581
ALK	Q9UM73	TAU	P10636	Yes	Yes	No	REACH_ProtMapperSIGNORProtMapper	SIGNOR:33452442 ProtMapper:33452442
ALK	Q9UM73	SFPQ	P23246	Yes	No	Yes	phosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:28633417 PhosphoSite:17537995 ProtMapper:17537995 SIGNOR:17537995

Page 1 of 2Next

Protein Complex Composition

39 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
CTBP1 GALK1 LCOR LCORL PRDM2 RREB1 ZBTB18 ZNF516	P51570 Q13029 Q13363 Q8N3X6 Q92618 Q92766 Q96JN0 Q99592	0:0:0:0:0:0:0:0	hu.MAP
ACSS2 CYCS GALK2 MVD	P53602 P99999 Q01415 Q9NR19	0:0:0:0	hu.MAP
GALK2 GALM PABPC3 ZC3H3	Q01415 Q8IXZ2 Q96C23 Q9H361	0:0:0:0	hu.MAP2
GALK2 GALM	Q01415 Q96C23	0:0	hu.MAP2
GALK2 GALM PABPC3	Q01415 Q96C23 Q9H361	0:0:0	hu.MAP2
GALK2 PABPC3	Q01415 Q9H361	0:0	hu.MAP2
ALKBH1	Q13686	8	PDB	PDB:6ie2
ALKBH3 ASCC1 ASCC2 ASCC3 TRIP4	Q15650 Q8N3C0 Q8N9N2 Q96Q83 Q9H1I8	0:0:0:0:0	hu.MAP2
ALKBH6 ARB2A EFL1 FAM98B	Q3KRA9 Q52LJ0 Q7Z2Z2 Q8WUF8	0:0:0:0	hu.MAP2
ALKBH6 ARB2A	Q3KRA9 Q8WUF8	0:0	hu.MAP2

Page 3 of 4Previous Next

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	30875722

Sequence, Structure & Domains

Sequences

Length

1,620

Mass

176,442

Sequence

MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP

3D Structural Models

Turn

705..707; 921..923; 999..1001

Helix

698..704; 718..720; 788..794; 800..807; 896..898; 907..913; 987..989; 1087..1092; 1105..1107; 1113..1115; 1158..1173; 1204..1211; 1223..1242; 1252..1254; 1272..1280; 1288..1290; 1293..1295; 1298..1303; 1308..1323; 1335..1343; 1356..1365; 1370..1372; 1376..1388; 1390..1393

Beta Strand

675..677; 680..685; 692..694; 713..715; 724..727; 730..739; 747..751; 757..765; 770..774; 782..784; 808..810; 812..814; 825..831; 834..841; 860..862; 865..867; 875..877; 890..892; 928..930; 936..938; 956..959; 963..965; 970..975; 978..984; 990..993; 995..997; 1004..1006; 1012..1014; 1016..1022; 1096..1098; 1101..1103; 1116..1124; 1126..1135; 1137..1140; 1145..1152; 1154..1156; 1182..1186; 1188..1197; 1215..1217; 1255..1258; 1260..1263; 1266..1268; 1284..1286; 1574..1576; 1582..1584

3D Structure

Electron microscopy (2); NMR spectroscopy (5); X-ray crystallography (72)

Domain & Motif Annotations

Compositional Bias

654..666; Basic and acidic residues; 1410..1419; Basic and acidic residues

Domain (CC)

The EGF-like region drives the cytokine specificity for ALKAL2..; DOMAIN: The heparin-binding region binds heparin glycosaminoglycan (PubMed:25605972, PubMed:34646012). Heparin-binding is required for ALKAL2-driven activation (PubMed:34646012).

Domain (FT)

264..427; MAM 1; 437..473; LDL-receptor class A; 478..636; MAM 2; 1116..1392; Protein kinase

Region

48..70; Heparin-binding region; 650..674; Disordered; 987..1025; EGF-like; 1408..1463; Disordered; 1514..1540; Disordered

Protein Families

Protein kinase superfamily
Tyr protein kinase family
Insulin receptor subfamily

Sequence Similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

Clinical Relevance

Disease Involvement

Cancer-related genesDisease variantFDA approved drug targetsProto-oncogene

Related Diseases

Adrenal cancer Breast cancer Colorectal cancer Diffuse large B-cell lymphoma Lung cancer Lymphoma Mature T-cell lymphoma Metastatic tumour Non-small-cell lung cancer Solid tumour/cancer

Biomarker

Phase 1; Phase 2; Approved; Investigative; Patented

Drug Targets

FDA approved drug targets

Drugs

CERITINIB X-396 CRIZOTINIB IL-10 RETASPIMYCIN HYDROCHLORIDE NIVOLUMAB NULL ALECTINIB ENTRECTINIB CENISERTIB AFATINIB PEMBROLIZUMAB DOXORUBICIN HYDROCHLORIDE ENSARTINIB CHEMBL:CHEMBL379975 TEPOTINIB CEMIPLIMAB-RWLC ZOLEDRONIC ACID ANHYDROUS APG-2449 LORLATINIB VANDETANIB RIBOCICLIB VINCRISTINE SULFATE IDASANUTLIN DACTOLISIB GEFITINIB DABRAFENIB NAVITOCLAX ATEZOLIZUMAB ALK INHIBITOR ASP3026 BRIGATINIB ALK INHIBITOR TAE684 AZD3463 TOPOTECAN HYDROCHLORIDE ERLOTINIB FORITINIB SUCCINATE GW441756X DINACICLIB TALETRECTINIB IPILIMUMAB CARBOPLATIN IFOSFAMIDE TPX-0131 TRAMETINIB DIMETHYL SULFOXIDE DOVITINIB TAK-715 TEMOZOLOMIDE PLB1003 BELIZATINIB GILTERITINIB EG5 KINESIN-RELATED MOTOR PROTEIN INHIBITOR 4SC-205 RAMUCIRUMAB JAK3 INHIBITOR II DALANTERCEPT ETOPOSIDE SELUMETINIB SHP2 INHIBITOR PF-07284892 LUMINESPIB DURVALUMAB BRENTUXIMAB VEDOTIN PAZOPANIB CISPLATIN IRINOTECAN HYDROCHLORIDE IRUPLINALKIB PD-0166285 CARBAMAZEPINE ALVOCIDIB GSK-1838705A CP-547632 PALBOCICLIB TOZASERTIB P53/HDM2 INTERACTION INHIBITOR CGM097 REPOTRECTINIB BATOPROTAFIB CYCLOPHOSPHAMIDE ANHYDROUS CONTELTINIB PEMETREXED DISODIUM JNJ-7706621 MTI-31 FULVESTRANT LINIFANIB METHOTREXATE FILGOTINIB DEXAMETHASONE MILADEMETAN RG-1530 CRENOLANIB ONALESPIB IXAZOMIB TAMATINIB ILORASERTIB HESPERADIN ALK/C-MET INHIBITOR TQ-B3139 ALK/TRK INHIBITOR TSR-011 OSIMERTINIB BEVACIZUMAB-AWWB CYTARABINE HJC0152 SARACATINIB ALECTINIB HYDROCHLORIDE ASP-3026 IMATINIB TREMELIMUMAB VENETOCLAX THZ1 CHEMBL:CHEMBL1997335 CHEMBL:CHEMBL546797 PF-562271 GANETESPIB ALK INHIBITOR NVL-655 CEDIRANIB FICONALKIB NVP-TAE 226 CEP-37440 OCTREOTIDE ACETATE SIROLIMUS

Antibody

HPA010694

Interaction Protein

ENSG00000165731

Interaction Count

Interaction Dataset

intact_biogrid