Protein detail
ICAM5
Intercellular adhesion molecule 5 (ICAM-5) (Telencephalin)
Entry name ICAM5 | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 2 | Transmembrane count 1 | Protein classification Plasma proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information12
Protein Names
Intercellular adhesion molecule 5 (ICAM-5) (Telencephalin)
Protein Class (2)
Plasma proteinsPredicted membrane proteins
Transmembrane
836..856; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
TLCNTLN
Gene Description
Intercellular adhesion molecule 5
Chromosome
19
Position
10289952-10296778
Supporting publications (n)
2
EVMP confidence score
0.25
Fluorescence & Localization2
Cell SpecificEsophageal apical cellsSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway5
Cellular Component (3)
Molecular Function (2)
Biological Process (3)
Reactome (4)
Mediation Categories
Immune mediation
Relations & Evidence47
Enzyme-Mediated Modification (1)
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ICAM5 | PRKCA | P17252 | T | 184 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling (44)
44 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | LOCATE | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | connectomeDB2020 | Yes | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | CellChatDB | Yes | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | OmniPath | Yes | No | No | Yes | No |
| ig_like | cell_adhesion | HGNC | Yes | Yes | No | Yes | No |
| adhesion | adhesion | HGNC | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | Zhong2015 | Yes | Yes | No | Yes | No |
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Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 12881314 |
Sequence, Structure & Domains12
Sequences
Length
924
Mass
97,116
Sequence
MPGPSPGLRRALLGLWAALGLGLFGLSAVSQEPFWADLQPRVAFVERGGSLWLNCSTNCPRPERGGLETSLRRNGTQRGLRWLARQLVDIREPETQPVCFFRCARRTLQARGLIRTFQRPDRVELMPLPPWQPVGENFTLSCRVPGAGPRASLTLTLLRGAQELIRRSFAGEPPRARGAVLTATVLARREDHGANFSCRAELDLRPHGLGLFENSSAPRELRTFSLSPDAPRLAAPRLLEVGSERPVSCTLDGLFPASEARVYLALGDQNLSPDVTLEGDAFVATATATASAEQEGARQLVCNVTLGGENRETRENVTIYSFPAPLLTLSEPSVSEGQMVTVTCAAGAQALVTLEGVPAAVPGQPAQLQLNATENDDRRSFFCDATLDVDGETLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQTLRCEARGNPEPSVHCARSDGGAVLALGLLGPVTRALSGTYRCKAANDQGEAVKDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSGELGAVIEGLLRVAREHAGTYRCEATNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGATEGVLLPLAPPDPSPRAPRIPRVLAPGIYVCNATNRHGSVAKTVVVSAESPPEMDESTCPSHQTWLEGAEASALACAARGRPSPGVRCSREGIPWPEQQRVSREDAGTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPPGGVRPGGNFTLTCRAEAWPPAQISWRAPPGALNIGLSSNNSTLSVAGAMGSHGGEYECAATNAHGRHARRITVRVAGPWLWVAVGGAAGGAALLAAGAGLAFYVQSTACKKGEYNVQEAESSGEAVCLNGAGGGAGGAAGAEGGPEAAGGAAESPAEGEVFAIQLTSA
3D Structural Models
Helix
150..152; 189..191; 205..207; 257..259; 374..376
Beta Strand
36..46; 49..57; 63..68; 70..79; 82..90; 92..95; 98..103; 106..111; 113..118; 130..133; 136..144; 153..159; 162..168; 179..186; 195..203; 211..215; 223..226; 232..234; 237..241; 245..251; 253..256; 261..271; 274..278; 281..288; 295..306; 309..320; 326..330; 332..335; 339..345; 348..354; 366..371; 379..389; 392..405
3D Structure
X-ray crystallography (4)
Domain & Motif Annotations
Compositional Bias
891..903; Gly residues
Domain (CC)
Ig-like C2-type 1 domain mediates neuronal homophilic adhesion with Ig-like C2-type 4-5 domains.
Domain (FT)
48..130; Ig-like C2-type 1; 135..235; Ig-like C2-type 2; 242..329; Ig-like C2-type 3; 337..402; Ig-like C2-type 4; 408..486; Ig-like C2-type 5; 491..568; Ig-like C2-type 6; 573..662; Ig-like C2-type 7; 666..739; Ig-like C2-type 8; 746..830; Ig-like C2-type 9
Region
891..911; Disordered
Protein Families (2)
- Immunoglobulin superfamily
- ICAM family
Sequence Similarities
Belongs to the immunoglobulin superfamily. ICAM family.
Clinical Relevance4
Supporting Publications2
| PMID | Title | Abstract |
|---|---|---|
| 32854315 | Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study. | Recent studies have highlighted the importance of Aβ and tau-containing extracellular vesicles (EVs) in AD. |
| 40730843 | Single urinary extracellular vesicle proteomics identifies complement receptor CD35 as a biomarker for sepsis-associated acute kidney injury. | No abstract available |