Protein detail

ICAM5

Intercellular adhesion molecule 5 (ICAM-5) (Telencephalin)

Entry name ICAM5	UniProt ID Q9UMF0	EVMP confidence score 0.25
Supporting publications (n) 2	Transmembrane count 1	Protein classification Plasma proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information12

Protein Names

Intercellular adhesion molecule 5 (ICAM-5) (Telencephalin)

Protein Class (2)

Plasma proteinsPredicted membrane proteins

Transmembrane

836..856; Helical

Transmembrane Count

Ensembl

ENSG00000105376

Entrez Gene Symbol

ICAM5

Gene Synonym (2)

TLCNTLN

Gene Description

Intercellular adhesion molecule 5

Chromosome

Position

10289952-10296778

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization2

Cell SpecificEsophageal apical cellsSingle-Nuclei Brain Specificcentral nervous system macrophage

Function & Pathway5

Cellular Component (3)

Molecular Function (2)

Biological Process (3)

Reactome (4)

Mediation Categories

Immune mediation

Relations & Evidence47

Enzyme-Mediated Modification (1)

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
ICAM5	PRKCA	P17252	T	184	phosphorylation	KEA	KEA:17570479

Ligand-Receptor Signaling (44)

44 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No
transmembrane_phobius	transmembrane_predicted	Almen2009	No	No	No	Yes	No
transmembrane_sosui	transmembrane_predicted	Almen2009	No	No	No	Yes	No
transmembrane_tmhmm	transmembrane_predicted	Almen2009	No	No	No	Yes	No

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	ICAM5	Q9UMF0	2	PDB	PDB:4oia

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	12881314

Sequence, Structure & Domains12

Sequences

Length

924

Mass

97,116

Sequence

MPGPSPGLRRALLGLWAALGLGLFGLSAVSQEPFWADLQPRVAFVERGGSLWLNCSTNCPRPERGGLETSLRRNGTQRGLRWLARQLVDIREPETQPVCFFRCARRTLQARGLIRTFQRPDRVELMPLPPWQPVGENFTLSCRVPGAGPRASLTLTLLRGAQELIRRSFAGEPPRARGAVLTATVLARREDHGANFSCRAELDLRPHGLGLFENSSAPRELRTFSLSPDAPRLAAPRLLEVGSERPVSCTLDGLFPASEARVYLALGDQNLSPDVTLEGDAFVATATATASAEQEGARQLVCNVTLGGENRETRENVTIYSFPAPLLTLSEPSVSEGQMVTVTCAAGAQALVTLEGVPAAVPGQPAQLQLNATENDDRRSFFCDATLDVDGETLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQTLRCEARGNPEPSVHCARSDGGAVLALGLLGPVTRALSGTYRCKAANDQGEAVKDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSGELGAVIEGLLRVAREHAGTYRCEATNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGATEGVLLPLAPPDPSPRAPRIPRVLAPGIYVCNATNRHGSVAKTVVVSAESPPEMDESTCPSHQTWLEGAEASALACAARGRPSPGVRCSREGIPWPEQQRVSREDAGTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPPGGVRPGGNFTLTCRAEAWPPAQISWRAPPGALNIGLSSNNSTLSVAGAMGSHGGEYECAATNAHGRHARRITVRVAGPWLWVAVGGAAGGAALLAAGAGLAFYVQSTACKKGEYNVQEAESSGEAVCLNGAGGGAGGAAGAEGGPEAAGGAAESPAEGEVFAIQLTSA

3D Structural Models

Helix

150..152; 189..191; 205..207; 257..259; 374..376

Beta Strand

36..46; 49..57; 63..68; 70..79; 82..90; 92..95; 98..103; 106..111; 113..118; 130..133; 136..144; 153..159; 162..168; 179..186; 195..203; 211..215; 223..226; 232..234; 237..241; 245..251; 253..256; 261..271; 274..278; 281..288; 295..306; 309..320; 326..330; 332..335; 339..345; 348..354; 366..371; 379..389; 392..405

3D Structure

X-ray crystallography (4)

Domain & Motif Annotations

Compositional Bias

891..903; Gly residues

Domain (CC)

Ig-like C2-type 1 domain mediates neuronal homophilic adhesion with Ig-like C2-type 4-5 domains.

Domain (FT)

48..130; Ig-like C2-type 1; 135..235; Ig-like C2-type 2; 242..329; Ig-like C2-type 3; 337..402; Ig-like C2-type 4; 408..486; Ig-like C2-type 5; 491..568; Ig-like C2-type 6; 573..662; Ig-like C2-type 7; 666..739; Ig-like C2-type 8; 746..830; Ig-like C2-type 9

Region

891..911; Disordered

Protein Families (2)

Immunoglobulin superfamily
ICAM family

Sequence Similarities

Belongs to the immunoglobulin superfamily. ICAM family.

Clinical Relevance4

Antibody (3)

HPA008943 HPA009083 CAB025178

Interaction Protein

ENSG00000116663

Interaction Count

Interaction Dataset

biogrid_bioplex

Supporting Publications2

PMID	Title	Abstract
32854315	Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study.	Recent studies have highlighted the importance of Aβ and tau-containing extracellular vesicles (EVs) in AD.
40730843	Single urinary extracellular vesicle proteomics identifies complement receptor CD35 as a biomarker for sepsis-associated acute kidney injury.	No abstract available