Protein detail

PCDGG

Protocadherin gamma-B4 (PCDH-gamma-B4) (Cadherin-20) (Fibroblast cadherin-2)

Entry name PCDGG	UniProt ID Q9UN71	EVMP confidence score 0.40
Supporting publications (n) 1	Transmembrane count 1	Protein classification Predicted membrane proteins

Basic Information

Protein Names

Protocadherin gamma-B4 (PCDH-gamma-B4) (Cadherin-20) (Fibroblast cadherin-2)

Protein Class

Predicted membrane proteins

Transmembrane

690..710; Helical

Transmembrane Count

Ensembl

ENSG00000253953

Entrez Gene Symbol

PCDHGB4

Gene Synonym (3)

CDH20FIB2PCDH-GAMMA-B4

Gene Description

Protocadherin gamma subfamily B, 4

Chromosome

Position

141387698-141512975

Supporting publications (n)

EVMP confidence score

0.40

Fluorescence & Localization

Tissue SpecificcervixCell SpecificEsophageal apical cellsBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes

Function & Pathway

Cellular Component (2)

Molecular Function

GO:0005509 calcium ion binding

Biological Process (3)

KEGG

hsa04519 Cadherin signaling

Canonical Pathways (3)

M119 Pid erb genomic pathway
M58 Pid ar pathway
M200 Pid era genomic pathway

Mediation Categories

Adhesion and uptake mediation

Relations & Evidence32

Ligand-Receptor Signaling (28)

28 records.

Category	Parent	Database	Plasma Membrane (Transmembrane)
plasma_membrane	plasma_membrane	Cellinker	Yes
plasma_membrane	plasma_membrane	OmniPath	Yes
plasma_membrane_transmembrane	plasma_membrane_transmembrane	Membranome	Yes
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	Yes
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	Yes
cell_surface	cell_surface	Surfaceome	Yes
cell_surface	cell_surface	OmniPath	Yes
transmembrane	transmembrane_predicted	Phobius	Yes

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Regulatory Interaction Network (2)

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PCDA2	Q9Y5H9	PCDGG	Q9UN71	Yes	Yes		SIGNOR	SIGNOR:16697637
PCDAA	Q9Y5I2	PCDGG	Q9UN71	Yes	Yes		SIGNOR	SIGNOR:16697637

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
Pcdha7-Pcdhgb4 complex	PCDHA7 PCDHGB4	Q9UN71 Q9UN72	1:1	Compleat	Compleat:HC2918	15347688

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	13	36064647 37322475 41068253 33592500 30915084 41307968 33309826 31805958 38207106 39001700 36982312 32854315 37670049

Sequence, Structure & Domains

Sequences

Length

923

Mass

99,927

Sequence

MGSGAGELGRAERLPVLFLFLLSLFCPALCEQIRYRIPEEMPKGSVVGNLATDLGFSVQELPTRKLRVSSEKPYFTVSAESGELLVSSRLDREEICGKKPACALEFEAVAENPLNFYHVNVEIEDINDHTPKFTQNSFELQISESAQPGTRFILGSAHDADIGSNTLQNYQLSPSDHFSLINKEKSDGSKYPEMVLKTPLDREKQKSYHLTLTALDFGAPPLSSTAQIHVLVTDANDNAPVFSQDVYRVSLSENVYPGTTVLQVTATDQDEGVNAEITFSFSEASQITQFDLNSNTGEITVLNTLDFEEVKEYSIVLEARDGGGMIAQCTVEVEVIDENDNAPEVIFQSLPNLIMEDAELGTHIALLKVRDKDSRHNGEVTCKLEGDVPFKILTSSRNTYKLVTDAVLDREQNPEYNITVTATDRGKPPLSSSSSITLHIGDVNDNAPVFSQSSYIVHVAENNPPGASISQVRASDPDLGPNGQVSYCIMASDLEQRELSSYVSISAESGVVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVDDRNDNAPRVLYPALGPDGSALFDMVPHAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAVRQRLLVAVRDGGQPPLSATATLHLVFADSLQEVLPDITDRPDPSDLQAELQFYLVVALALISVLFLVAMILAIALRLRRSSSPASWSCFQPGLCVKSESVVPPNYSEGTLPYSYNLCVAHTGKTEFNFLKCSEQLSSGQDILCGDSSGALFPLCNSSELTSHQQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UN71-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q9UN71-2; Sequence=VSP_008690, VSP_008691

Alternative Sequence

800..803; QAPP -> VSFL (in isoform 2); 804..923; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias

913..923; Basic residues

Domain (FT)

31..133; Cadherin 1; 134..242; Cadherin 2; 243..345; Cadherin 3; 346..450; Cadherin 4; 451..560; Cadherin 5; 568..673; Cadherin 6

Region

797..832; Disordered; 893..923; Disordered

Clinical Relevance

Antibody (2)

HPA008755 HPA010580

Supporting Publications1

PMID	Title	Related sentences
41167904	Accessing the proteome of extracellular vesicles via rapid acoustic isolation of a minute human blood plasma sample.	No related sentences available