Protein detail
PCDA4
Protocadherin alpha-4 (PCDH-alpha-4)
Entry name PCDA4 | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification Predicted membrane proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Protocadherin alpha-4 (PCDH-alpha-4)
Protein Class
Predicted membrane proteins
Transmembrane
698..718; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
CNR1CNRN1CRNR1PCDH-ALPHA4
Gene Description
Protocadherin alpha 4
Chromosome
5
Position
140806929-141012347
Supporting publications (n)
1
EVMP confidence score
0.40
Function & Pathway
Cellular Component
Molecular Function (3)
Biological Process (3)
Mediation Categories (2)
Adhesion and uptake mediationClinical-translation mediation
Relations & Evidence29
Ligand-Receptor Signaling (27)
27 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellChatDB | Yes | Yes | |||
| receptor | receptor | OmniPath | Yes | Yes | |||
| extracellular | extracellular | OmniPath | Yes | ||||
| intracellular | intracellular | LOCATE | Yes | ||||
| intracellular | intracellular | ComPPI | Yes | ||||
| intracellular | intracellular | OmniPath | Yes | ||||
| cell_surface_ligand | cell_surface_ligand | CellChatDB | Yes | Yes | |||
| adhesion | adhesion | HGNC | Yes | Yes | Yes | ||
| cell_surface_ligand | cell_surface_ligand | OmniPath | Yes | Yes | |||
| protocadherin | cell_adhesion | HGNC | Yes | Yes | Yes |
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Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PCDA4 | Q9UN74 | ITB1 | P05556 | Yes | Yes | SIGNOR | SIGNOR:16697637 |
Isolation & Detection Technology (1)
Sequence, Structure & Domains
Sequences
Length
947
Mass
102,293
Sequence
MEFSWGSGQESRRLLLLLLLLAAWEAGNGQLHYSVSEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKGRGGLLEVNLQNGILFVNSRIDREELCRRSAECSIHLEVIVDRPLQVFHVDVEVRDINDNPPVFPATQKNLSIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFSLEKPPDDELVKGLGLILRKSLDREEAPEIFLVLTATDGGKPELTGTVQLLITVLDANDNAPAFDRTIYKVRLLENVPNGTLVIKLNASDLDEGLNGDIVYSFSNDISPNVKSKFHIDPITGQIIVKGYIDFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNVPDLEFKSLSLPIREDAPLGTVIALISVSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVTARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAGGTGGAVSELVPWSVGVGHVVAKVRAVDADSGYNAWLSYELQPGTGGARIPFRVGLYTGEISTTRALDETDAPRHRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRALVGAVGPDAALVDVNVYLIIAICAVSSLLVLTLLLYTALRCSALPTEGACAPGKPTLVCSSAVGSWSYSQQRRPRVCSGEGPPKTDLMAFSPSLPDSRDREDQLQTTEESFAKPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UN74-1; Sequence=Displayed; Name=2; IsoId=Q9UN74-2; Sequence=VSP_000677, VSP_000678
Alternative Sequence
796..798; PRQ -> VSV (in isoform 2); 799..947; Missing (in isoform 2)
Domain & Motif Annotations
Compositional Bias
906..920; Basic and acidic residues
Repeat
734..737; PXXP 1; 774..777; PXXP 2; 796..799; PXXP 3; 829..832; PXXP 4; 870..873; PXXP 5; 888..891; PXXP 6
Domain (CC)
Cadherin 1 to cadherin 4 domains mediate homophilic trans-interaction, the interaction with an identical protocadherin expressed by a neighboring cell. This is a head-to-tail interaction, the cadherin 1 domain interacting with the cadherin 4 domain and the cadherin 2 domain interacting the cadherin 3 domain of the other protocadherin. The cadherin 6 domain mediates promiscuous interactions with protocadherins on the same cell membrane. Each cadherin domain binds three calcium ions.
Domain (FT)
30..133; Cadherin 1; 134..242; Cadherin 2; 243..350; Cadherin 3; 351..455; Cadherin 4; 456..565; Cadherin 5; 588..678; Cadherin 6
Region
734..891; 6 X 4 AA repeats of P-X-X-P; 738..947; Required for interaction with FYN; 754..805; Disordered; 828..853; Disordered; 868..947; Disordered
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 36146834 | Human Cytomegalovirus Modifies Placental Small Extracellular Vesicle Composition to Enhance Infection of Fetal Neural Cells In Vitro. | No related sentences available |