Protein detail
PCDAC
Protocadherin alpha-12 (PCDH-alpha-12)
Entry name PCDAC | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification Predicted membrane proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Protocadherin alpha-12 (PCDH-alpha-12)
Protein Class
Predicted membrane proteins
Transmembrane
698..718; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
PCDH-ALPHA12
Gene Description
Protocadherin alpha 12
Chromosome
5
Position
140875302-141012347
Supporting publications (n)
1
EVMP confidence score
0.40
Fluorescence & Localization
Tissue Specificlymphoid tissueCell SpecificHofbauer cellsSingle-Nuclei Brain SpecificleukocyteBlood Cell SpecificT-regBlood Lineage SpecificT-cells
Function & Pathway
Cellular Component
Molecular Function
Biological Process (3)
Mediation Categories
Adhesion and uptake mediation
Relations & Evidence29
Ligand-Receptor Signaling (27)
27 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellChatDB | Yes | Yes | |||
| receptor | receptor | OmniPath | Yes | Yes | |||
| extracellular | extracellular | OmniPath | Yes | ||||
| intracellular | intracellular | LOCATE | Yes | ||||
| intracellular | intracellular | ComPPI | Yes | ||||
| intracellular | intracellular | OmniPath | Yes | ||||
| cell_surface_ligand | cell_surface_ligand | CellChatDB | Yes | Yes | |||
| cell_surface_ligand | cell_surface_ligand | OmniPath | Yes | Yes | |||
| protocadherin | cell_adhesion | HGNC | Yes | Yes | Yes | ||
| adhesion | adhesion | HGNC | Yes | Yes | Yes |
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Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PCDAC | Q9UN75 | ITB1 | P05556 | Yes | Yes | SIGNOR | SIGNOR:16697637 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture | Western blotting | 1 | 40098346 |
Sequence, Structure & Domains
Sequences
Length
941
Mass
101,652
Sequence
MVIIGPRGPGSQRLLLSLLLLAAWEVGSGQLHYSVYEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKRHGDLLEVNLQNGILFVNSRIDREKLCGRSAECSIHLEVIVDRPLQVFHVDVEVKDINDNPPVFREREQKVPVSESAPLDSHFPLEGASDADIGVNSLLTYALSLNENFELKIKTKKDKSILPELVLRKLLDREQTPKLNLLLMVIDGGKPELTGSVQIQITVLDVNDNGPAFDKPSYKVVLSENVQNDTRVIQLNASDPDEGLNGEISYGIKMILPVSEKCMFSINPDTGEIRIYGELDFEENNAYEIQVNAIDKGIPSMAGHSMVLVEVLDVNDNVPEVMVTSLSLPVQEDAQVGTVIALISVSDRDSGANGQVICSLTPHVPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQKNALVSYSLVERRVGEHALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLATPAGSAGGAVSELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPAAVGAHIPFHVGLYTGEISTTRILDEADAPRHRLLVLVKDHGEPALTSTATVLVSLVENGQAPKTSSRASVGAVDPEAALVDINVYLIIAICAVSSLLVLTLLLYTALRCSAPPTVSRCAPGKPTLVCSSAVGSWSYSQQRRQRVCSAESPPKTDLMAFSPSLQLSREDCLNPPSEPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UN75-1; Sequence=Displayed; Name=2; IsoId=Q9UN75-2; Sequence=VSP_000695, VSP_000696
Alternative Sequence
790..792; PRQ -> VSY (in isoform 2); 793..941; Missing (in isoform 2)
Domain & Motif Annotations
Compositional Bias
900..914; Basic and acidic residues
Repeat
734..737; PXXP 1; 790..793; PXXP 2; 823..826; PXXP 3; 863..866; PXXP 4; 882..885; PXXP 5
Domain (FT)
30..133; Cadherin 1; 134..242; Cadherin 2; 243..350; Cadherin 3; 351..455; Cadherin 4; 456..565; Cadherin 5; 581..678; Cadherin 6
Region
734..885; 5 X 4 AA repeats of P-X-X-P; 818..941; Disordered
Clinical Relevance
Antibody
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 36146834 | Human Cytomegalovirus Modifies Placental Small Extracellular Vesicle Composition to Enhance Infection of Fetal Neural Cells In Vitro. | No related sentences available |