Protein detail
S6A14
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (Amino acid transporter ATB0+) (Solute carrier family 6 member 14)
Entry name S6A14 | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 2 | Transmembrane count 12 | Protein classification Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (Amino acid transporter ATB0+) (Solute carrier family 6 member 14)
Protein Class (6)
Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters
Protein Function (4)
- Human disease related genes:Endocrine and metabolic diseases:Other endocrine and metabolic diseases
- Disease related genes
- Transporters:Electrochemical Potential-driven transporters
- Potential drug targets
Transmembrane
45..65; Helical; Name=1; 72..92; Helical; Name=2; 110..130; Helical; Name=3; 235..255; Helical; Name=4; 261..281; Helical; Name=5; 315..335; Helical; Name=6; 348..368; Helical; Name=7; 399..419; Helical; Name=8; 450..477; Helical; Name=9; 480..500; Helical; Name=10; 528..548; Helical; Name=11; 563..583; Helical; Name=12
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Gene Description
Solute carrier family 6 member 14
Chromosome
X
Position
116436606-116461458
Supporting publications (n)
2
EVMP confidence score
0.40
Fluorescence & Localization
Cell SpecificEsophageal apical cellsSingle-Nuclei Brain SpecificoligodendrocyteBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function (4)
- Human disease related genes:Endocrine and metabolic diseases:Other endocrine and metabolic diseases
- Disease related genes
- Transporters:Electrochemical Potential-driven transporters
- Potential drug targets
Cellular Component (5)
Molecular Function (7)
- GO:0001761 beta-alanine transmembrane transporter activity
- GO:0015171 amino acid transmembrane transporter activity
- GO:0015173 aromatic amino acid transmembrane transporter activity
- GO:0015374 neutral, basic amino acid:sodium:chloride symporter activity
- GO:0015657 branched-chain amino acid:sodium symporter activity
- GO:0022858 alanine transmembrane transporter activity
- GO:1901235 (R)-carnitine transmembrane transporter activity
Biological Process (3)
Reactome (6)
Mediation Categories (2)
Clinical-translation mediationFusion and delivery mediation
Relations & Evidence22
Ligand-Receptor Signaling (21)
21 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | Yes | ||||
| extracellular | extracellular | DGIdb | |||||
| extracellular | extracellular | OmniPath | |||||
| transporter | transporter | Surfaceome | Yes | ||||
| solute_carrier | transporter | Almen2009 | Yes | ||||
| slc6 | transporter | Surfaceome | Yes | ||||
| slc | transporter | Surfaceome | Yes | ||||
| transporter | transporter | OmniPath | Yes | ||||
| transmembrane | transmembrane | UniProt_location | |||||
| transmembrane | transmembrane | UniProt_topology |
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Sequence, Structure & Domains
Sequences
Length
642
Mass
72,153
Sequence
MDKLKCPSFFKCREKEKVSASSENFHVGENDENQDRGNWSKKSDYLLSMIGYAVGLGNVWRFPYLTYSNGGGAFLIPYAIMLALAGLPLFFLECSLGQFASLGPVSVWRILPLFQGVGITMVLISIFVTIYYNVIIAYSLYYMFASFQSELPWKNCSSWSDKNCSRSPIVTHCNVSTVNKGIQEIIQMNKSWVDINNFTCINGSEIYQPGQLPSEQYWNKVALQRSSGMNETGVIVWYLALCLLLAWLIVGAALFKGIKSSGKVVYFTALFPYVVLLILLVRGATLEGASKGISYYIGAQSNFTKLKEAEVWKDAATQIFYSLSVAWGGLVALSSYNKFKNNCFSDAIVVCLTNCLTSVFAGFAIFSILGHMAHISGKEVSQVVKSGFDLAFIAYPEALAQLPGGPFWSILFFFMLLTLGLDSQFASIETITTTIQDLFPKVMKKMRVPITLGCCLVLFLLGLVCVTQAGIYWVHLIDHFCAGWGILIAAILELVGIIWIYGGNRFIEDTEMMIGAKRWIFWLWWRACWFVITPILLIAIFIWSLVQFHRPNYGAIPYPDWGVALGWCMIVFCIIWIPIMAIIKIIQAKGNIFQRLISCCRPASNWGPYLEQHRGERYKDMVDPKKEADHEIPTVSGSRKPE
Domain & Motif Annotations
Compositional Bias
622..632; Basic and acidic residues
Region
622..642; Disordered
Protein Families (2)
- Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family
- SLC6A14 subfamily
Sequence Similarities
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A14 subfamily.
Clinical Relevance
Disease Involvement
Obesity
Related Diseases (2)
Biomarker
Terminated
Antibody
Supporting Publications2
| PMID | Title | Related sentences |
|---|---|---|
| 33919183 | Multiple-Cycle Polymeric Extracellular Vesicle Precipitation and Its Evaluation by Targeted Mass Spectrometry. | No related sentences available |
| 35611462 | Extracellular vesicles expressing CEACAM proteins in the urine of bladder cancer patients. | No related sentences available |