Protein detail
PACN2
Protein kinase C and casein kinase substrate in neurons protein 2 (Syndapin-2) (Syndapin-II) (SdpII)
Entry name PACN2 | UniProt ID | EVMP confidence score 0.75 |
Supporting publications (n) 29 | Transmembrane count | Protein classification Predicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Protein kinase C and casein kinase substrate in neurons protein 2 (Syndapin-2) (Syndapin-II) (SdpII)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
SDPII
Gene Description
Protein kinase C and casein kinase substrate in neurons 2
Chromosome
22
Position
42835412-43015149
Supporting publications (n)
29
EVMP confidence score
0.75
Fluorescence & Localization
Tissue Specificbone marrowCell SpecificcDCSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificneutrophilBlood Lineage SpecificgranulocytesSecretome LocationIntracellular and membraneSecretome FunctionReceptor
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component (15)
- GO:0005737 cytoplasm
- GO:0005768 endosome
- GO:0005769 early endosome
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0005901 caveola
- GO:0005911 cell-cell junction
- GO:0005925 focal adhesion
- GO:0016607 nuclear speck
- GO:0032587 ruffle membrane
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Molecular Function (6)
Biological Process (3)
Reactome (3)
Mediation Categories (2)
Adhesion and uptake mediationFusion and delivery mediation
Relations & Evidence15
Enzyme-Mediated Modification (1)
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| PACSIN2 | PRKCA | P17252 | S | 313 | phosphorylation | PhosphoSite |
Ligand-Receptor Signaling (9)
9 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | |||||
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| fbar_actin_dynamics_endocytosis | intracellular_intercellular_related | HGNC | Yes | ||||
| intracellular_intercellular_related | intracellular_intercellular_related | OmniPath | Yes | ||||
| plasma_membrane | plasma_membrane | UniProt_location | |||||
| plasma_membrane | plasma_membrane | OmniPath |
Regulatory Interaction Network (2)
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KAPCA | P17612 | PACN2 | Q9UNF0 | Yes | Yes | SIGNOR | SIGNOR:31801866 | |
| KPCA | P17252 | PACN2 | Q9UNF0 | Yes | REACH_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper | ProtMapper:31801866PhosphoSite:31801866 |
Protein Complex Composition (2)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometryWestern blotting | 1 | 38716512 |
Sequence, Structure & Domains
Sequences
Length
486
Mass
55,739
Sequence
MSVTYDDSVGVEVSSDSFWEVGNYKRTVKRIDDGHRLCSDLMNCLHERARIEKAYAQQLTEWARRWRQLVEKGPQYGTVEKAWMAFMSEAERVSELHLEVKASLMNDDFEKIKNWQKEAFHKQMMGGFKETKEAEDGFRKAQKPWAKKLKEVEAAKKAHHAACKEEKLAISREANSKADPSLNPEQLKKLQDKIEKCKQDVLKTKEKYEKSLKELDQGTPQYMENMEQVFEQCQQFEEKRLRFFREVLLEVQKHLDLSNVAGYKAIYHDLEQSIRAADAVEDLRWFRANHGPGMAMNWPQFEEWSADLNRTLSRREKKKATDGVTLTGINQTGDQSLPSKPSSTLNVPSNPAQSAQSQSSYNPFEDEDDTGSTVSEKDDTKAKNVSSYEKTQSYPTDWSDDESNNPFSSTDANGDSNPFDDDATSGTEVRVRALYDYEGQEHDELSFKAGDELTKMEDEDEQGWCKGRLDNGQVGLYPANYVEAIQ
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UNF0-1; Sequence=Displayed; Name=2; IsoId=Q9UNF0-2; Sequence=VSP_004517
Alternative Sequence
344..384; Missing (in isoform 2)
3D Structural Models
Turn
21..24; 192..195
Helix
25..72; 77..106; 108..119; 129..169; 172..177; 185..188; 189..191; 197..255; 257..259; 263..275; 279..290
Beta Strand
126..128
3D Structure
X-ray crystallography (4)
Domain & Motif Annotations
Compositional Bias
327..347; Polar residues; 348..363; Low complexity; 383..396; Polar residues; 404..416; Polar residues
Motif
362..364; NPF1; 405..407; NPF2; 417..419; NPF3
Coiled Coil
25..274
Domain (CC)
The F-BAR domain forms a coiled coil and mediates membrane-binding and membrane tubulation (PubMed:19549836). Autoinhibition of these functions is mediated by an interaction between the SH3 and F-BAR domains (PubMed:20188097, PubMed:23236520). The F-Bar domain also mediates the binding to the cell actin cytoskeleton through the interaction with CAV-1 (By similarity).; DOMAIN: (Microbial infection) The SH3 domain is required for the cell-to-cell spreading of HIV-1 virions.
Domain (FT)
11..282; F-BAR; 426..486; SH3
Region
1..362; (Microbial infection) Interaction with HCV NS5A; 314..426; Disordered
Protein Families
PACSIN family
Sequence Similarities
Belongs to the PACSIN family.
Clinical Relevance
Drugs (2)
Interaction Protein (10)
ENSG00000039560ENSG00000082438ENSG00000100106ENSG00000100139ENSG00000106078ENSG00000106299ENSG00000117560ENSG00000124507ENSG00000133030ENSG00000165912
Interaction Count
10
Interaction Dataset (3)
biogrid_opencellintact_biogrid_opencellintact_biogrid
Supporting Publications29
| PMID | Title | Related sentences |
|---|---|---|
| 38590132 | Proteomic Identification of Small Extracellular Vesicle Proteins LAMB1 and Histone H4 for Prostate Cancer Diagnosis and Risk Stratification. | Proteomic Identification of Small Extracellular Vesicle Proteins LAMB1 and Histone H4 for Prostate Cancer Diagnosis and Risk Stratification. |
| 38716512 | Assessment of urine sample collection and processing variables for extracellular vesicle-based proteomics. | No related sentences available |
| 38891077 | Altered Extracellular Vesicle-Derived Protein and microRNA Signatures in Bronchoalveolar Lavage Fluid from Patients with Chronic Obstructive Pulmonary Disease. | No related sentences available |
| 39207047 | The trajectory of vesicular proteomic signatures from HBV-HCC by chitosan-magnetic bead-based separation and DIA-proteomic analysis. | No related sentences available |
| 40189497 | Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis. | No related sentences available |
| 40465195 | Extracellular vesicle proteomics uncovers energy metabolism, complement system, and endoplasmic reticulum stress response dysregulation postexercise in males with myalgic encephalomyelitis/chronic fatigue syndrome. | No related sentences available |
| 40840701 | Multiomics analysis to evaluate the enrichment of extracellular vesicles from human plasma. | No related sentences available |
| 40985879 | TurboID-Mediated Profiling of Glioblastoma-Derived Extracellular Vesicle Cargo Proteins. | No related sentences available |
| 41068253 | Identification of plasma extracellular vesicle protein biomarkers in diabetic retinopathy progression. | No related sentences available |
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