Protein detail
ABCG2
Broad substrate specificity ATP-binding cassette transporter ABCG2 (EC 7.6.2.2) (ATP-binding cassette sub-family G member 2) (Breast cancer resistance protein) (CDw338) (Mitoxantrone resistance-associated protein) (Placenta-specific ATP-binding cassette transporter) (Urate exporter) (CD antigen CD338)
Protein symbol ABCG2 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 6 | Protein classification Cancer-related genesCD markersEnzymesHuman disease related genesMetabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Broad substrate specificity ATP-binding cassette transporter ABCG2 (EC 7.6.2.2) (ATP-binding cassette sub-family G member 2) (Breast cancer resistance protein) (CDw338) (Mitoxantrone resistance-associated protein) (Placenta-specific ATP-binding cassette transporter) (Urate exporter) (CD antigen CD338)
Protein Class
Cancer-related genesCD markersEnzymesHuman disease related genesMetabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Predicted intracellular proteins
- CD markers
- Enzymes
- ENZYME proteins
- Cancer-related genes:Candidate cancer biomarkers
- Transporters:Primary Active Transporters
- Human disease related genes:Musculoskeletal diseases:Other musculoskeletal diseases
Transmembrane
396..416; Helical; 429..449; Helical; 478..498; Helical; 507..527; Helical; 536..556; Helical; 631..651; Helical
Transmembrane Count
6
Ensembl
Entrez Gene Symbol
Gene Synonym
ABCPBCRPCD338EST157481MXR
Gene Description
ATP binding cassette subfamily G member 2 (Junior blood group)
Chromosome
4
Position
88090150-88231628
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificadipose tissueCell SpecificAdipocytesSingle-Nuclei Brain Specificvascular associated smooth muscle cell
Function & Pathway
Protein Function
- Predicted intracellular proteins
- CD markers
- Enzymes
- ENZYME proteins
- Cancer-related genes:Candidate cancer biomarkers
- Transporters:Primary Active Transporters
- Human disease related genes:Musculoskeletal diseases:Other musculoskeletal diseases
Cellular Component
Molecular Function
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0008514 organic anion transmembrane transporter activity
- GO:0008559 ABC-type xenobiotic transporter activity
- GO:0015143 urate transmembrane transporter activity
- GO:0015225 biotin transmembrane transporter activity
- GO:0015562 efflux transmembrane transporter activity
- GO:0016887 ATP hydrolysis activity
- GO:0032217 riboflavin transmembrane transporter activity
- GO:0042626 ATPase-coupled transmembrane transporter activity
- GO:0042802 identical protein binding
- GO:0042803 protein homodimerization activity
- GO:0042910 xenobiotic transmembrane transporter activity
- GO:0046624 sphingolipid transporter activity
Biological Process
KEGG
Reactome
- R-hsa-2161522 abacavir adme
- R-hsa-2161517 abacavir transmembrane transport
- R-hsa-8953897 cellular responses to stimuli
- R-hsa-9711123 cellular response to chemical stress
- R-hsa-9793528 ciprofloxacin adme
- R-hsa-9734767 developmental cell lineages
- R-hsa-9734779 developmental cell lineages of the integumentary system
- R-hsa-9725554 differentiation of keratinocytes in interfollicular epidermis in mammalian skin
- R-hsa-9748784 drug adme
- R-hsa-189451 heme biosynthesis
- R-hsa-189483 heme degradation
- R-hsa-917937 iron uptake and transport
- R-hsa-9755511 keap1 nfe2l2 pathway
- R-hsa-556833 metabolism of lipids
- R-hsa-189445 metabolism of porphyrins
- R-hsa-9818032 nfe2l2 regulating mdr associated enzymes
- R-hsa-9759194 nuclear events mediated by nfe2l2
- R-hsa-9753281 paracetamol adme
- R-hsa-1660661 sphingolipid de novo biosynthesis
- R-hsa-428157 sphingolipid metabolism
- R-hsa-382551 transport of small molecules
Mediation Categories
Clinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ABCG2 | PIM1 | P11309 | T | 362 | phosphorylation | Sparser_ProtMapperPhosphoSite_MIMPMIMPSIGNORProtMapperRLIMS-P_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:23261525ProtMapper:25810011ProtMapper:27596051SIGNOR:18056989ProtMapper:22098950ProtMapper:22248732ProtMapper:21118091 |
Ligand-Receptor Signaling
30 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | LOCATE | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| apical_cell_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | No | No |
| cell_surface | cell_surface | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PIM1 | P11309 | ABCG2 | Q9UNQ0 | Yes | Yes | No | Sparser_ProtMapperPhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperREACH_ProtMapperRLIMS-P_ProtMapperIntActSIGNOR_ProtMapperLit-BM-17PhosphoSitePhosphoSite_ProtMapper | IntAct:18056989ProtMapper:23261525ProtMapper:25810011ProtMapper:27596051SIGNOR:18056989ProtMapper:22098950ProtMapper:22248732Lit-BM-17:18056989ProtMapper:21118091PhosphoSite:18056989ProtMapper:18056989 |
Protein Complex Composition
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| Abcg5-Abcg4 complex | ABCG2ABCG4ABCG5 | Q9H172Q9H222Q9UNQ0 | 1:1:1 | Compleat | Compleat:HC2917 | 14504269 |
| Abcg8-Abcg4 complex | ABCG2ABCG4ABCG8 | Q9H172Q9H221Q9UNQ0 | 1:1:1 | Compleat | Compleat:HC2457 | 14504269 |
| ABCG2 | Q9UNQ0 | 2 | PDB | PDB:6vxiPDB:5njgPDB:6vxjPDB:8bhtPDB:6hbuPDB:8py4PDB:6hijPDB:8u2cPDB:7nfdPDB:7oj8PDB:6hzmPDB:8p8aPDB:8q7bPDB:7neqPDB:8p7wPDB:7nezPDB:8p8jPDB:8qcmPDB:6vxfPDB:6etiPDB:6ffcPDB:8pxoPDB:8bi0PDB:6hcoPDB:6feqPDB:5nj3PDB:7ojhPDB:6vxhPDB:7oji |
Sequence, Structure & Domains
Sequences
Length
655
Mass
72,314
Sequence
MSSSNVEVFIPVSQGNTNGFPATASNDLKAFTEGAVLSFHNICYRVKLKSGFLPCRKPVEKEILSNINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELHQLSGGEKKKKITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAAGQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPGLNATGNNPCNYATCTGEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYLKLLFLKKYS
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UNQ0-1; Sequence=Displayed; Name=2; IsoId=Q9UNQ0-2; Sequence=VSP_014232, VSP_014233
Alternative Sequence
550..611; IFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPGLNATGNNPCNYATCTGE -> VCWSISQPLHLGCHGFSTSAFHDMDLRLCSIMNFWDKTSAQDSMQQETILVTMQHVLAKNIW (in isoform 2); 612..655; Missing (in isoform 2)
3D Structural Models
Turn
82..84; 99..101; 212..215; 413..415; 597..599
Helix
86..94; 117..120; 136..147; 154..168; 171..173; 188..200; 218..233; 247..250; 270..272; 273..280; 290..299; 303..307; 329..337; 340..352; 373..390; 393..412; 422..439; 440..445; 446..449; 452..460; 466..476; 478..481; 484..497; 503..528; 535..550; 558..560; 563..566; 567..571; 573..586; 610..616; 624..649
Beta Strand
37..45; 62..71; 73..79; 104..108; 121..124; 132..135; 150..152; 174..177; 181..183; 205..211; 237..241; 254..260; 263..268; 286..288; 418..421; 552..556; 602..605
3D Structure
Electron microscopy (29)
Domain & Motif Annotations
Domain (CC)
The extracellular loop 3 (ECL3) is involved in binding porphyrins and transfer them to other carriers, probably albumin.
Domain (FT)
37..286; ABC transporter; 389..651; ABC transmembrane type-2
Protein Families
- ABC transporter superfamily
- ABCG family
- Eye pigment precursor importer (TC 3.A.1.204) subfamily
Sequence Similarities
Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
Clinical Relevance
Disease Involvement
Cancer-related genes
Related Diseases
Biomarker
Approved
Drugs
NEVIRAPINECLOZAPINESIROLIMUSNULLFOLIC ACIDTARIQUIDARLAMIVUDINERHODAMINE123PRAVASTATIN SODIUMIMATINIBCHEMBL:CHEMBL428402ITRACONAZOLESILYMARINDIFLOMOTECANTENOFOVIRNILOTINIBDASATINIB ANHYDROUSCYCLOSPORINERISPERIDONEGENISTEINVORICONAZOLECOMPOUND 14 [PMID: 30925062]KETOCONAZOLEN-DESMETHYLTAMOXIFENELACRIDARTOPOTECAN HYDROCHLORIDEFELODIPINEPRASTERONEEFAVIRENZLEUCOVORIN CALCIUMLOVASTATINEPIRUBICINZIDOVUDINEPRAZOSINPACLITAXELCURCUMINSULFASALAZINEDOCETAXEL ANHYDROUSIGURATIMODDOXORUBICIN HYDROCHLORIDETELMISARTANDOLUTEGRAVIR SODIUMDAUNORUBICIN LIPOSOMALSORAFENIBLEVOFLOXACIN ANHYDROUSMITOXANTRONEDELAVIRDINELENVATINIBFLUVASTATINERLOTINIBCHEMBL:CHEMBL444075ANHYDROUS TACROLIMUSRETUSINCAPECITABINECHLORPROMAZINENITROFURANTOIN, MACROCRYSTALSKO 143SN-38HUMAN CHORIONIC GONADOTROPINERLOTINIB HYDROCHLORIDEOSIMERTINIBETRAVIRINECYCLOPHOSPHAMIDE ANHYDROUSALVOCIDIBAXITINIB