Protein detail

MINP1

Multiple inositol polyphosphate phosphatase 1 (EC 3.1.3.62) (2,3-bisphosphoglycerate 3-phosphatase) (2,3-BPG phosphatase) (EC 3.1.3.80)

Entry name MINP1	UniProt ID Q9UNW1	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count	Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted secreted proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Multiple inositol polyphosphate phosphatase 1 (EC 3.1.3.62) (2,3-bisphosphoglycerate 3-phosphatase) (2,3-BPG phosphatase) (EC 3.1.3.80)

Protein Class (8)

Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted secreted proteins

Protein Function (8)

Predicted intracellular proteins
Human disease related genes:Cancers:Cancers of endocrine organs
Potential drug targets
Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
Enzymes
Predicted secreted proteins
ENZYME proteins:Hydrolases
Disease related genes

Ensembl

ENSG00000107789

Entrez Gene Symbol

MINPP1

Gene Synonym

MIPP

Gene Description

Multiple inositol-polyphosphate phosphatase 1

Chromosome

Position

87504875-87553461

Supporting publications (n)

EVMP confidence score

0.25

Function & Pathway8

Protein Function (8)

Predicted intracellular proteins
Human disease related genes:Cancers:Cancers of endocrine organs
Potential drug targets
Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
Enzymes
Predicted secreted proteins
ENZYME proteins:Hydrolases
Disease related genes

Cellular Component (4)

Molecular Function (14)

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Biological Process (3)

KEGG (3)

Reactome

R-hsa-1483249 inositol phosphate metabolism

Canonical Pathways (2)

M214 Pid erbb1 internalization pathway
M261 Pid p53 regulation pathway

Mediation Categories

Metabolism mediation

Relations & Evidence20

Ligand-Receptor Signaling (13)

13 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ecm	ecm	MatrixDB	Yes	No	Yes	No	No
ecm	ecm	OmniPath	Yes	No	Yes	No	No
extracellular	extracellular	OmniPath	No	No	Yes	No	No
intracellular	intracellular	ComPPI	No	No	Yes	No	No
intracellular	intracellular	GO_Intercell	No	No	Yes	No	No
intracellular	intracellular	UniProt_location	No	No	Yes	No	No
intracellular	intracellular	OmniPath	No	No	Yes	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	Yes	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	Yes	No	No
secreted	secreted	UniProt_keyword	No	No	Yes	No	No

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Protein Complex Composition (6)

6 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
MINPP1 P4HB TRAPPC1 TRAPPC10 TRAPPC2B TRAPPC3 TRAPPC4 TRAPPC5 TRAPPC6A TRAPPC8 UBC	O43617 O75865 P07237 P0CG48 P0DI82 P48553 Q8IUR0 Q9UNW1 Q9Y296 Q9Y2L5 Q9Y5R8	1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7735
ERO1A ERO1B H2AX MINPP1 P4HB PDIA3 PDIA4 UBC	P07237 P0CG48 P13667 P16104 P30101 Q86YB8 Q96HE7 Q9UNW1	1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9406
CWF19L1 MINPP1 MSH2 PRKDC SFPQ TMOD2	P23246 P43246 P78527 Q69YN2 Q9NZR1 Q9UNW1	0:0:0:0:0:0	hu.MAP2
IVD MINPP1 SEC23A	P26440 Q15436 Q9UNW1	0:0:0	hu.MAP
CDCP1 MINPP1 PDIA6 VWA1	Q15084 Q6PCB0 Q9H5V8 Q9UNW1	0:0:0:0	hu.MAP2
CDCP1 MINPP1 VWA1	Q6PCB0 Q9H5V8 Q9UNW1	0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometryMass spectrometry [LTQ-FT Ultra]	34	36064647 38113368 37322475 33304478 36497184 25755179 34064677 40189497 38895962 41068253 33592500 32854315 38014595 27487081 38891077 30915084 32560723 31617158 32916986 41307968 36146834 33309826 40840701 37670049 31805958 38607062 32230970 38207106 34576246 39001700 37438638 39207047 37926756 26826536

Sequence, Structure & Domains8

Sequences

Length

487

Mass

55,051

Sequence

MLRAPGCLLRTSVAPAAALAAALLSSLARCSLLEPRDPVASSLSPYFGTKTRYEDVNPVLLSGPEAPWRDPELLEGTCTPVQLVALIRHGTRYPTVKQIRKLRQLHGLLQARGSRDGGASSTGSRDLGAALADWPLWYADWMDGQLVEKGRQDMRQLALRLASLFPALFSRENYGRLRLITSSKHRCMDSSAAFLQGLWQHYHPGLPPPDVADMEFGPPTVNDKLMRFFDHCEKFLTEVEKNATALYHVEAFKTGPEMQNILKKVAATLQVPVNDLNADLIQVAFFTCSFDLAIKGVKSPWCDVFDIDDAKVLEYLNDLKQYWKRGYGYTINSRSSCTLFQDIFQHLDKAVEQKQRSQPISSPVILQFGHAETLLPLLSLMGYFKDKEPLTAYNYKKQMHRKFRSGLIVPYASNLIFVLYHCENAKTPKEQFRVQMLLNEKVLPLAYSQETVSFYEDLKNHYKDILQSCQTSEECELARANSTSDEL

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9UNW1-1; Sequence=Displayed; Name=2; IsoId=Q9UNW1-2; Sequence=VSP_014552, VSP_014555; Name=3; IsoId=Q9UNW1-3; Sequence=VSP_014553, VSP_014554; Name=4; IsoId=Q9UNW1-4; Sequence=VSP_044569

Alternative Sequence

1..213; MLRAPGCLLRTSVAPAAALAAALLSSLARCSLLEPRDPVASSLSPYFGTKTRYEDVNPVLLSGPEAPWRDPELLEGTCTPVQLVALIRHGTRYPTVKQIRKLRQLHGLLQARGSRDGGASSTGSRDLGAALADWPLWYADWMDGQLVEKGRQDMRQLALRLASLFPALFSRENYGRLRLITSSKHRCMDSSAAFLQGLWQHYHPGLPPPDVAD -> MCLFQLCGLVRY (in isoform 4); 279..312; DLIQVAFFTCSFDLAIKGVKSPWCDVFDIDDAKV -> GLSQFLLQSSSSLVMQRLFFHCFLSWATSKTRNP (in isoform 2); 279..284; DLIQVA -> GIRIFK (in isoform 3); 285..487; Missing (in isoform 3); 313..487; Missing (in isoform 2)

Domain & Motif Annotations

Motif

484..487; Prevents secretion from ER

Protein Families (2)

Histidine acid phosphatase family
MINPP1 subfamily

Sequence Similarities

Belongs to the histidine acid phosphatase family. MINPP1 subfamily.

Clinical Relevance2

Disease Involvement

Disease variant

Antibody

HPA026859

Supporting Publications1

PMID	Title	Abstract
26775013	Proteomic characterization of circulating extracellular vesicles identifies novel serum myeloma associated markers.	No abstract available