Protein detail
GP132
Probable G-protein coupled receptor 132 (G2 accumulation protein)
Protein symbol GP132 | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 7 | Protein classification G-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteins |
Basic Information
Protein Names
Probable G-protein coupled receptor 132 (G2 accumulation protein)
Protein Class
G-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Predicted intracellular proteins
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
46..68; Helical; Name=1; 80..102; Helical; Name=2; 117..138; Helical; Name=3; 159..178; Helical; Name=4; 198..220; Helical; Name=5; 247..269; Helical; Name=6; 289..311; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym
G2A
Gene Description
G protein-coupled receptor 132
Chromosome
14
Position
105049395-105065445
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Cell SpecificChoroid plexus epithelial cellsSingle-Nuclei Brain Specificependymal cell
Function & Pathway
Protein Function
- Predicted intracellular proteins
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component
Molecular Function
Biological Process
Reactome
Canonical Pathways
M214 Pid erbb1 internalization pathway
Mediation Categories
Receptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
39 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | HPMR | No | Yes | No | Yes | No |
| receptor | receptor | Surfaceome | No | Yes | No | Yes | No |
| gpcr | receptor | DGIdb | No | Yes | No | Yes | No |
| gpcr | receptor | Almen2009 | No | Yes | No | Yes | No |
| rhodopsin | receptor | Almen2009 | No | Yes | No | Yes | No |
| gpcr | receptor | UniProt_keyword | No | Yes | No | Yes | No |
| seven_transmembrane_7tm | receptor | HPMR | No | Yes | No | Yes | No |
| 7tm_a | receptor | HPMR | No | Yes | No | Yes | No |
| 7tm_a_ogr1_gpr4_7tm_a | receptor | HPMR | No | Yes | No | Yes | No |
| rhodopsin | receptor | Surfaceome | No | Yes | No | Yes | No |
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Regulatory Interaction Network
11 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| GP132 | Q9UNW8 | GNAO | P09471 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
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Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Antibody arrayMass spectrometry | 0 |
Sequence, Structure & Domains
Sequences
Length
380
Mass
42,499
Sequence
MCPMLLKNGYNGNATPVTTTAPWASLGLSAKTCNNVSFEESRIVLVVVYSAVCTLGVPANCLTAWLALLQVLQGNVLAVYLLCLALCELLYTGTLPLWVIYIRNQHRWTLGLLACKVTAYIFFCNIYVSILFLCCISCDRFVAVVYALESRGRRRRRTAILISACIFILVGIVHYPVFQTEDKETCFDMLQMDSRIAGYYYARFTVGFAIPLSIIAFTNHRIFRSIKQSMGLSAAQKAKVKHSAIAVVVIFLVCFAPYHLVLLVKAAAFSYYRGDRNAMCGLEERLYTASVVFLCLSTVNGVADPIIYVLATDHSRQEVSRIHKGWKEWSMKTDVTRLTHSRDTEELQSPVALADHYTFSRPVHPPGSPCPAKRLIEESC
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=G2A-a; IsoId=Q9UNW8-1; Sequence=Displayed; Name=2; IsoId=Q9UNW8-2; Sequence=VSP_008404; Name=3; Synonyms=G2A-b; IsoId=Q9UNW8-3; Sequence=VSP_054592
Alternative Sequence
1..188; Missing (in isoform 2); 1..11; MCPMLLKNGYN -> MP (in isoform 3)
3D Structural Models
Turn
90..94; 190..192
Helix
38..71; 76..86; 95..101; 113..144; 147..153; 156..179; 195..207; 209..227; 234..271; 279..311; 313..330; 335..345
Beta Strand
230..232
3D Structure
Electron microscopy (4)
Domain & Motif Annotations
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.