Protein detail
FZD1
Frizzled-1 (Fz-1) (hFz1) (FzE1)
Protein symbol FZD1 | UniProt ID | EVMP score 0.63 |
Frequency 9 | Transmembrane count 7 | Protein classification Cancer-related genesG-protein coupled receptorsPlasma proteinsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Frizzled-1 (Fz-1) (hFz1) (FzE1)
Protein Class
Cancer-related genesG-protein coupled receptorsPlasma proteinsPredicted membrane proteinsTransporters
Protein Function
- Transporters
- Cancer-related genes:Candidate cancer biomarkers
- G-protein coupled receptors:Family fz/smo receptors
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
323..343; Helical; Name=1; 355..375; Helical; Name=2; 403..423; Helical; Name=3; 446..466; Helical; Name=4; 490..510; Helical; Name=5; 537..557; Helical; Name=6; 602..622; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym
DKFZp564G072
Gene Description
Frizzled class receptor 1
Chromosome
7
Position
91264433-91271326
Frequency
9
EVMP Score
0.63
Fluorescence & Localization
Tissue Specificsmooth muscleCell SpecificBreast myoepithelial cellsSingle-Nuclei Brain Specificvascular associated smooth muscle cellBlood Cell Specificneutrophil
Function & Pathway
Protein Function
- Transporters
- Cancer-related genes:Candidate cancer biomarkers
- G-protein coupled receptors:Family fz/smo receptors
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component
Molecular Function
Biological Process
KEGG
- hsa04150 mTOR signaling pathway
- KEGG:hsa04310 Wnt signaling pathway
- KEGG:hsa04390 Hippo signaling pathway
- KEGG:hsa04519 Cadherin signaling
- KEGG:hsa04550 Signaling pathways regulating pluripotency of stem cells
- KEGG:hsa04916 Melanogenesis
- KEGG:hsa04934 Cushing syndrome
- KEGG:hsa05010 Alzheimer disease
- KEGG:hsa05022 Pathways of neurodegeneration - multiple diseases
- KEGG:hsa05165 Human papillomavirus infection
- KEGG:hsa05200 Pathways in cancer
- KEGG:hsa05205 Proteoglycans in cancer
- KEGG:hsa05217 Basal cell carcinoma
- KEGG:hsa05224 Breast cancer
- KEGG:hsa05225 Hepatocellular carcinoma
- KEGG:hsa05226 Gastric cancer
Reactome
- R-hsa-4608870 asymmetric localization of pcp proteins
- R-hsa-3858494 beta catenin independent wnt signaling
- R-hsa-373080 class b 2 secretin family receptors
- R-hsa-4641262 disassembly of the destruction complex and recruitment of axin to the membrane
- R-hsa-500792 gpcr ligand binding
- R-hsa-4086400 pcp ce pathway
- R-hsa-372790 signaling by gpcr
- R-hsa-195721 signaling by wnt
- R-hsa-201681 tcf dependent signaling in response to wnt
Canonical Pathways
- M37 Pid nfkappab canonical pathway
- M258 Pid bard1 pathway
- M214 Pid erbb1 internalization pathway
Mediation Categories
Adhesion and uptake mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
58 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | Baccin2019 | No | Yes | No | No | No |
| receptor | receptor | SignaLink_function | No | Yes | No | No | No |
| frizzled | receptor | Almen2009 | No | Yes | No | No | No |
| gpcr | receptor | Almen2009 | No | Yes | No | No | No |
| gpcr | receptor | UniProt_keyword | No | Yes | No | No | No |
| cytokine | receptor | Baccin2019 | No | Yes | No | No | No |
| gpcr | receptor | Surfaceome | No | Yes | No | No | No |
| frizzled | receptor | Surfaceome | No | Yes | No | No | No |
| class_f_frizzled | receptor | GPCRdb | No | Yes | No | No | No |
| class_f_frizzled_protein | receptor | GPCRdb | No | Yes | No | No | No |
Regulatory Interaction Network
7 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| WNT3A | P56704 | FZD1 | Q9UP38 | Yes | Yes | No | iTALKSIGNORHPRD_LRdbtalklrMPPIHPRDRamilowski2015_Baccin2019CancerCellMapWangRamilowski2015HPRD_talklrBaccin2019STRING_talklrEMBRACECellCallCellTalkDBFantom5_LRdbNetPathconnectomeDB2020SPIKE_LCLRdbSPIKE | connectomeDB2020:10557084Baccin2019:10557084NetPath:10557084SIGNOR:10601008CellTalkDB:10557084SIGNOR:21078818MPPI:10557084SPIKE:11029007SPIKE_LC:11029007HPRD:10557084LRdb:10557084CancerCellMap:10557084 |
| WN10B | O00744 | FZD1 | Q9UP38 | Yes | Yes | No | WangSIGNOR | SIGNOR:19008118SIGNOR:12055200 |
| FZD1 | Q9UP38 | DVL3 | Q92997 | Yes | Yes | No | WangSIGNOR | SIGNOR:23151663 |
| FZD1 | Q9UP38 | DVL1 | O14640 | Yes | Yes | No | WangSIGNOR | SIGNOR:22944199 |
| FZD1 | Q9UP38 | DVL2 | O14641 | Yes | Yes | No | WangSIGNOR | SIGNOR:23151663 |
| WNT1 | P04628 | FZD1 | Q9UP38 | Yes | Yes | Yes | CellTalkDBFantom5_LRdbiTALKKirouac2010talklrNetPathSIGNORconnectomeDB2020Cui2007CancerCellMapWangLRdbSTRING_talklrEMBRACECellCall | connectomeDB2020:24032637SIGNOR:22944199NetPath:10557084SIGNOR:15578921CellTalkDB:24032637SIGNOR:16936075CancerCellMap:10557084 |
| WNT7B | P56706 | FZD1 | Q9UP38 | Yes | Yes | No | Fantom5_LRdbCellTalkDBHPMR_LRdbiTALKtalklrNetPathRamilowski2015SIGNORconnectomeDB2020Baccin2019Ramilowski2015_Baccin2019WangLRdbSTRING_talklrEMBRACECellCallHPMR_talklr | NetPath:15923619Baccin2019:15923619LRdb:15923619CellTalkDB:15923619SIGNOR:15923619connectomeDB2020:15923619 |
Protein Complex Composition
Isolation & Detection Technology
Sequence, Structure & Domains
Sequences
Length
647
Mass
71,158
Sequence
MAEEEAPKKSRAAGGGASWELCAGALSARLAEEGSGDAGGRRRPPVDPRRLARQLLLLLWLLEAPLLLGVRAQAAGQGPGQGPGPGQQPPPPPQQQQSGQQYNGERGISVPDHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGAGELCVGQNTSDKGTPTPSLLPEFWTSNPQHGGGGHRGGFPGGAGASERGKFSCPRALKVPSYLNYHFLGEKDCGAPCEPTKVYGLMYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYTAVAVAYIAGFLLEDRVVCNDKFAEDGARTVAQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQWERSWVAQSCKSYAIPCPHLQAGGGAPPHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRLTNSKQGETTV
3D Structural Models
Turn
303..308; 371..380; 462..466; 485..491; 529..531; 559..561; 609..611
Helix
278..280; 313..343; 354..370; 400..430; 437..440; 441..443; 444..449; 454..461; 492..513; 532..555; 562..573; 600..608; 612..621; 624..635
Beta Strand
293..295; 309..311; 345..347; 350..352; 385..388; 395..397; 431..433; 468..470; 472..482; 575..577
3D Structure
Electron microscopy (2)
Domain & Motif Annotations
Motif
625..630; Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members; 645..647; PDZ-binding
Domain (CC)
Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.; DOMAIN: The FZ domain is involved in binding with Wnt ligands.
Domain (FT)
111..230; FZ
Region
74..104; Disordered
Protein Families
G-protein coupled receptor Fz/Smo family
Sequence Similarities
Belongs to the G-protein coupled receptor Fz/Smo family.
Clinical Relevance
Disease Involvement
Cancer-related genes
Antibody