Protein detail
FZD1
Frizzled-1 (Fz-1) (hFz1) (FzE1)
Entry name FZD1 | UniProt ID | EVMP confidence score 0.63 |
Supporting publications (n) 9 | Transmembrane count 7 | Protein classification Cancer-related genesG-protein coupled receptorsPlasma proteinsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Frizzled-1 (Fz-1) (hFz1) (FzE1)
Protein Class (5)
Cancer-related genesG-protein coupled receptorsPlasma proteinsPredicted membrane proteinsTransporters
Protein Function (4)
- Transporters
- Cancer-related genes:Candidate cancer biomarkers
- G-protein coupled receptors:Family fz/smo receptors
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
323..343; Helical; Name=1; 355..375; Helical; Name=2; 403..423; Helical; Name=3; 446..466; Helical; Name=4; 490..510; Helical; Name=5; 537..557; Helical; Name=6; 602..622; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym
DKFZp564G072
Gene Description
Frizzled class receptor 1
Chromosome
7
Position
91264433-91271326
Supporting publications (n)
9
EVMP confidence score
0.63
Fluorescence & Localization5
Tissue Specificsmooth muscleCell SpecificBreast myoepithelial cellsSingle-Nuclei Brain Specificvascular associated smooth muscle cellBlood Cell Specificneutrophil
Function & Pathway8
Protein Function (4)
- Transporters
- Cancer-related genes:Candidate cancer biomarkers
- G-protein coupled receptors:Family fz/smo receptors
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component (4)
Molecular Function (7)
Biological Process (3)
KEGG (16)
- hsa04150 mTOR signaling pathway
- KEGG:hsa04310 Wnt signaling pathway
- KEGG:hsa04390 Hippo signaling pathway
- KEGG:hsa04519 Cadherin signaling
- KEGG:hsa04550 Signaling pathways regulating pluripotency of stem cells
- KEGG:hsa04916 Melanogenesis
- KEGG:hsa04934 Cushing syndrome
- KEGG:hsa05010 Alzheimer disease
- KEGG:hsa05022 Pathways of neurodegeneration - multiple diseases
- KEGG:hsa05165 Human papillomavirus infection
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Reactome (9)
- R-hsa-4608870 asymmetric localization of pcp proteins
- R-hsa-3858494 beta catenin independent wnt signaling
- R-hsa-373080 class b 2 secretin family receptors
- R-hsa-4641262 disassembly of the destruction complex and recruitment of axin to the membrane
- R-hsa-500792 gpcr ligand binding
- R-hsa-4086400 pcp ce pathway
- R-hsa-372790 signaling by gpcr
- R-hsa-195721 signaling by wnt
- R-hsa-201681 tcf dependent signaling in response to wnt
Canonical Pathways (3)
- M37 Pid nfkappab canonical pathway
- M258 Pid bard1 pathway
- M214 Pid erbb1 internalization pathway
Mediation Categories (2)
Adhesion and uptake mediationReceptor-signaling mediation
Relations & Evidence69
Ligand-Receptor Signaling (58)
58 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | GO_Intercell | No | No | No | No | No |
| transmembrane | transmembrane | CellPhoneDB | No | No | No | No | No |
| transmembrane | transmembrane | TopDB | No | No | No | No | No |
| transmembrane | transmembrane | LOCATE | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
Regulatory Interaction Network (7)
7 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| WNT3A | P56704 | FZD1 | Q9UP38 | Yes | Yes | No | iTALKSIGNORHPRD_LRdbtalklrMPPIHPRDRamilowski2015_Baccin2019CancerCellMapWangRamilowski2015HPRD_talklrBaccin2019STRING_talklrEMBRACECellCallCellTalkDBFantom5_LRdbNetPathconnectomeDB2020SPIKE_LCLRdbSPIKE | connectomeDB2020:10557084Baccin2019:10557084NetPath:10557084SIGNOR:10601008CellTalkDB:10557084SIGNOR:21078818MPPI:10557084SPIKE:11029007SPIKE_LC:11029007HPRD:10557084LRdb:10557084CancerCellMap:10557084 |
| WN10B | O00744 | FZD1 | Q9UP38 | Yes | Yes | No | WangSIGNOR | SIGNOR:19008118SIGNOR:12055200 |
| FZD1 | Q9UP38 | DVL3 | Q92997 | Yes | Yes | No | WangSIGNOR | SIGNOR:23151663 |
| FZD1 | Q9UP38 | DVL1 | O14640 | Yes | Yes | No | WangSIGNOR | SIGNOR:22944199 |
| FZD1 | Q9UP38 | DVL2 | O14641 | Yes | Yes | No | WangSIGNOR | SIGNOR:23151663 |
| WNT1 | P04628 | FZD1 | Q9UP38 | Yes | Yes | Yes | CellTalkDBFantom5_LRdbiTALKKirouac2010talklrNetPathSIGNORconnectomeDB2020Cui2007CancerCellMapWangLRdbSTRING_talklrEMBRACECellCall | connectomeDB2020:24032637SIGNOR:22944199NetPath:10557084SIGNOR:15578921CellTalkDB:24032637SIGNOR:16936075CancerCellMap:10557084 |
| WNT7B | P56706 | FZD1 | Q9UP38 | Yes | Yes | No | Fantom5_LRdbCellTalkDBHPMR_LRdbiTALKtalklrNetPathRamilowski2015SIGNORconnectomeDB2020Baccin2019Ramilowski2015_Baccin2019WangLRdbSTRING_talklrEMBRACECellCallHPMR_talklr | NetPath:15923619Baccin2019:15923619LRdb:15923619CellTalkDB:15923619SIGNOR:15923619connectomeDB2020:15923619 |
Protein Complex Composition (3)
Isolation & Detection Technology (1)
Sequence, Structure & Domains13
Sequences
Length
647
Mass
71,158
Sequence
MAEEEAPKKSRAAGGGASWELCAGALSARLAEEGSGDAGGRRRPPVDPRRLARQLLLLLWLLEAPLLLGVRAQAAGQGPGQGPGPGQQPPPPPQQQQSGQQYNGERGISVPDHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGAGELCVGQNTSDKGTPTPSLLPEFWTSNPQHGGGGHRGGFPGGAGASERGKFSCPRALKVPSYLNYHFLGEKDCGAPCEPTKVYGLMYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYTAVAVAYIAGFLLEDRVVCNDKFAEDGARTVAQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQWERSWVAQSCKSYAIPCPHLQAGGGAPPHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRLTNSKQGETTV
3D Structural Models
Turn
303..308; 371..380; 462..466; 485..491; 529..531; 559..561; 609..611
Helix
278..280; 313..343; 354..370; 400..430; 437..440; 441..443; 444..449; 454..461; 492..513; 532..555; 562..573; 600..608; 612..621; 624..635
Beta Strand
293..295; 309..311; 345..347; 350..352; 385..388; 395..397; 431..433; 468..470; 472..482; 575..577
3D Structure
Electron microscopy (2)
Domain & Motif Annotations
Motif
625..630; Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members; 645..647; PDZ-binding
Domain (CC)
Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.; DOMAIN: The FZ domain is involved in binding with Wnt ligands.
Domain (FT)
111..230; FZ
Region
74..104; Disordered
Protein Families
G-protein coupled receptor Fz/Smo family
Sequence Similarities
Belongs to the G-protein coupled receptor Fz/Smo family.
Clinical Relevance3
Disease Involvement
Cancer-related genes
Antibody
Supporting Publications9
| PMID | Title | Abstract |
|---|---|---|
| 27821849 | Detailed Analysis of Protein Topology of Extracellular Vesicles-Evidence of Unconventional Membrane Protein Orientation. | No abstract available |
| 32560723 | T2 and T17 cytokines alter the cargo and function of airway epithelium-derived extracellular vesicles. | No abstract available |
| 35119778 | Optimization of small extracellular vesicle isolation from expressed prostatic secretions in urine for in-depth proteomic analysis. | No abstract available |
| 36146834 | Human Cytomegalovirus Modifies Placental Small Extracellular Vesicle Composition to Enhance Infection of Fetal Neural Cells In Vitro. | No abstract available |
| 37322475 | Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration. | No abstract available |
| 38113368 | In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum. | No abstract available |
| 38207106 | Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity. | No abstract available |
| 38716512 | Assessment of urine sample collection and processing variables for extracellular vesicle-based proteomics. | No abstract available |
| 40189497 | Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis. | No abstract available |