Protein detail
EXOC7
Exocyst complex component 7 (Exocyst complex component Exo70)
Protein symbol EXOC7 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Exocyst complex component 7 (Exocyst complex component Exo70)
Protein Class
Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsTransporters
Protein Function
- Predicted intracellular proteins
- Potential drug targets
- Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
- Transporters:Transporter channels and pores
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym
BLOM4EXO70Exo70pKIAA1067YJL085W
Gene Description
Exocyst complex component 7
Chromosome
17
Position
76081016-76121576
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecificbrainCell SpecificBrain excitatory neurons
Function & Pathway
Protein Function
- Predicted intracellular proteins
- Potential drug targets
- Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
- Transporters:Transporter channels and pores
- Disease related genes
Cellular Component
Molecular Function
Biological Process
Reactome
- R-hsa-5620920 cargo trafficking to the periciliary membrane
- R-hsa-5617833 cilium assembly
- R-hsa-264876 insulin processing
- R-hsa-199991 membrane trafficking
- R-hsa-1852241 organelle biogenesis and maintenance
- R-hsa-2980736 peptide hormone metabolism
- R-hsa-1445148 translocation of slc2a4 glut4 to the plasma membrane
- R-hsa-5653656 vesicle mediated transport
- R-hsa-5620916 vxpx cargo targeting to cilium
Mediation Categories
Fusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
2 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| EXOC7 | MAPK1 | P28482 | S | 250 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:22595671SIGNOR:22595671 |
| EXOC7 | MAPK3 | P27361 | S | 250 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper |
Ligand-Receptor Signaling
7 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
3 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| RHOQ | P17081 | EXOC7 | Q9UPT5 | Yes | Yes | No | HPRDWangLit-BM-17SIGNOR | SIGNOR:12687004Lit-BM-17:12687004HPRD:12687004 |
| MK01 | P28482 | EXOC7 | Q9UPT5 | Yes | Yes | No | Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSite_ProtMapper | SIGNOR:22595671ProtMapper:22595671ProtMapper:30917119 |
| MK03 | P27361 | EXOC7 | Q9UPT5 | Yes | No | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:22595671 |
Protein Complex Composition
9 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| Exocyst EXOC5-EXOC6-EXOC7 subcomplex | EXOC5EXOC6EXOC7 | O00471Q8TAG9Q9UPT5 | 0:0:0 | CORUM | CORUM:6169 | 25964651 |
| EXOC4EXOC5EXOC6EXOC6BEXOC7EXOC8 | O00471Q8IYI6Q8TAG9Q96A65Q9UPT5Q9Y2D4 | 0:0:0:0:0:0 | hu.MAP2 | |||
| EXOC5EXOC6EXOC7EXOC8 | O00471Q8IYI6Q8TAG9Q9UPT5 | 0:0:0:0 | hu.MAP2 | |||
| EXOC5EXOC6EXOC6BEXOC7EXOC8 | O00471Q8IYI6Q8TAG9Q9UPT5Q9Y2D4 | 0:0:0:0:0 | hu.MAP | |||
| AKAP9CALM3CCP110EXOC7PCNTPPEF2 | O14830O43303O95613P0DP25Q99996Q9UPT5 | 1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC4857 | ||
| ARPC1ABLOC1S2BLOC1S6CCDC22DTNBP1EXOC7H4C4SNAPIN | O60826O95295P62805Q6QNY1Q92747Q96EV8Q9UL45Q9UPT5 | 1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC8583 | ||
| BBS1BBS2BBS4BBS7BBS9EXOC7PCM1TTC8 | Q15154Q3SYG4Q8IWZ6Q8NFJ9Q8TAM2Q96RK4Q9BXC9Q9UPT5 | 1:1:1:1:1:1:1:1 | CompleatCFinder | Compleat:HC5620 | ||
| EXOC4EXOC6EXOC7 | Q8TAG9Q96A65Q9UPT5 | 0:0:0 | hu.MAP2 | |||
| CDC5LDISC1EXOC4EXOC7 | Q96A65Q99459Q9NRI5Q9UPT5 | 1:1:1:1 | CompleatCFinder | Compleat:HC5993 |
Sequence, Structure & Domains
Sequences
Length
735
Mass
83,382
Sequence
MIPPQEASARRREIEDKLKQEEETLSFIRDSLEKSDQLTKNMVSILSSFESRLMKLENSIIPVHKQTENLQRLQENVEKTLSCLDHVISYYHVASDTEKIIREGPTGRLEEYLGSMAKIQKAVEYFQDNSPDSPELNKVKLLFERGKEALESEFRSLMTRHSKVVSPVLILDLISGDDDLEAQEDVTLEHLPESVLQDVIRISRWLVEYGRNQDFMNVYYQIRSSQLDRSIKGLKEHFHKSSSSSGVPYSPAIPNKRKDTPTKKPVKRPGTIRKAQNLLKQYSQHGLDGKKGGSNLIPLEGLLPCTPRGGLPGPWINAACVCAADISPGHEHDFRVKHLSEALNDKHGPLAGRDDMLDVETDAYIHCVSAFVKLAQSEYQLLADIIPEHHQKKTFDSLIQDALDGLMLEGENIVSAARKAIVRHDFSTVLTVFPILRHLKQTKPEFDQVLQGTAASTKNKLPGLITSMETIGAKALEDFADNIKNDPDKEYNMPKDGTVHELTSNAILFLQQLLDFQETAGAMLASQETSSSATSYSSEFSKRLLSTYICKVLGNLQLNLLSKSKVYEDPALSAIFLHNNYNYILKSLEKSELIQLVAVTQKTAERSYREHIEQQIQTYQRSWLKVTDYIAEKNLPVFQPGVKLRDKERQIIKERFKGFNDGLEELCKIQKAWAIPDTEQRDRIRQAQKTIVKETYGAFLQKFGSVPFTKNPEKYIKYGVEQVGDMIDRLFDTSA
Alternative Products
Event=Alternative splicing; Named isoforms=6; Name=3; IsoId=Q9UPT5-3; Sequence=Displayed; Name=1; IsoId=Q9UPT5-1; Sequence=VSP_008878; Name=2; IsoId=Q9UPT5-2; Sequence=VSP_001483; Name=4; IsoId=Q9UPT5-4; Sequence=VSP_008876, VSP_008877; Name=5; IsoId=Q9UPT5-5; Sequence=VSP_041098; Name=6; IsoId=Q9UPT5-6; Sequence=VSP_041099
Alternative Sequence
269..327; Missing (in isoform 5); 271..352; Missing (in isoform 2); 271..283; TIRKAQNLLKQYS -> EPPSWPISATARG (in isoform 4); 284..735; Missing (in isoform 4); 301..328; Missing (in isoform 6); 302..352; Missing (in isoform 1)
3D Structural Models
Domain & Motif Annotations
Coiled Coil
5..42; 63..85
Domain (CC)
The N-terminus is involved in SEC8 and ARHQ binding.; DOMAIN: The C-terminus is required for translocation to the plasma membrane.
Region
239..268; Disordered
Protein Families
EXO70 family
Sequence Similarities
Belongs to the EXO70 family.
Clinical Relevance
Disease Involvement
Epilepsy
Interaction Protein
ENSG00000070367ENSG00000090989ENSG00000096401ENSG00000105700ENSG00000109083ENSG00000116903ENSG00000131558ENSG00000138190ENSG00000144036ENSG00000146648ENSG00000180104ENSG00000185359
Interaction Count
12
Interaction Dataset
intact_biogrid