Protein detail

EXOC7

Exocyst complex component 7 (Exocyst complex component Exo70)

Entry name EXOC7	UniProt ID Q9UPT5	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Exocyst complex component 7 (Exocyst complex component Exo70)

Protein Class (5)

Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsTransporters

Protein Function (5)

Predicted intracellular proteins
Potential drug targets
Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
Transporters:Transporter channels and pores
Disease related genes

Ensembl

ENSG00000182473

Entrez Gene Symbol

EXOC7

Gene Synonym (5)

BLOM4EXO70Exo70pKIAA1067YJL085W

Gene Description

Exocyst complex component 7

Chromosome

Position

76081016-76121576

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization3

Tissue SpecificbrainCell SpecificBrain excitatory neurons

Function & Pathway7

Protein Function (5)

Predicted intracellular proteins
Potential drug targets
Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
Transporters:Transporter channels and pores
Disease related genes

Cellular Component (9)

Molecular Function (3)

Biological Process (3)

KEGG (2)

Reactome (9)

Mediation Categories (2)

Fusion and delivery mediationMetabolism mediation

Relations & Evidence22

Enzyme-Mediated Modification (2)

2 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
EXOC7	MAPK1	P28482	S	250	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:22595671 SIGNOR:22595671
EXOC7	MAPK3	P27361	S	250	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper

Ligand-Receptor Signaling (7)

7 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Regulatory Interaction Network (3)

3 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
RHOQ	P17081	EXOC7	Q9UPT5	Yes	Yes	No	HPRDWangLit-BM-17SIGNOR	SIGNOR:12687004 Lit-BM-17:12687004 HPRD:12687004
MK01	P28482	EXOC7	Q9UPT5	Yes	Yes	No	Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSite_ProtMapper	SIGNOR:22595671 ProtMapper:22595671 ProtMapper:30917119
MK03	P27361	EXOC7	Q9UPT5	Yes	No	No	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:22595671

Protein Complex Composition (9)

9 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
Exocyst EXOC5-EXOC6-EXOC7 subcomplex	EXOC5 EXOC6 EXOC7	O00471 Q8TAG9 Q9UPT5	0:0:0	CORUM	CORUM:6169	25964651
	EXOC4 EXOC5 EXOC6 EXOC6B EXOC7 EXOC8	O00471 Q8IYI6 Q8TAG9 Q96A65 Q9UPT5 Q9Y2D4	0:0:0:0:0:0	hu.MAP2
	EXOC5 EXOC6 EXOC7 EXOC8	O00471 Q8IYI6 Q8TAG9 Q9UPT5	0:0:0:0	hu.MAP2
	EXOC5 EXOC6 EXOC6B EXOC7 EXOC8	O00471 Q8IYI6 Q8TAG9 Q9UPT5 Q9Y2D4	0:0:0:0:0	hu.MAP
	AKAP9 CALM3 CCP110 EXOC7 PCNT PPEF2	O14830 O43303 O95613 P0DP25 Q99996 Q9UPT5	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4857
	ARPC1A BLOC1S2 BLOC1S6 CCDC22 DTNBP1 EXOC7 H4C4 SNAPIN	O60826 O95295 P62805 Q6QNY1 Q92747 Q96EV8 Q9UL45 Q9UPT5	1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8583
	BBS1 BBS2 BBS4 BBS7 BBS9 EXOC7 PCM1 TTC8	Q15154 Q3SYG4 Q8IWZ6 Q8NFJ9 Q8TAM2 Q96RK4 Q9BXC9 Q9UPT5	1:1:1:1:1:1:1:1	CompleatCFinder	Compleat:HC5620
	EXOC4 EXOC6 EXOC7	Q8TAG9 Q96A65 Q9UPT5	0:0:0	hu.MAP2
	CDC5L DISC1 EXOC4 EXOC7	Q96A65 Q99459 Q9NRI5 Q9UPT5	1:1:1:1	CompleatCFinder	Compleat:HC5993

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	2	27821849 38716512

Sequence, Structure & Domains10

Sequences

Length

735

Mass

83,382

Sequence

MIPPQEASARRREIEDKLKQEEETLSFIRDSLEKSDQLTKNMVSILSSFESRLMKLENSIIPVHKQTENLQRLQENVEKTLSCLDHVISYYHVASDTEKIIREGPTGRLEEYLGSMAKIQKAVEYFQDNSPDSPELNKVKLLFERGKEALESEFRSLMTRHSKVVSPVLILDLISGDDDLEAQEDVTLEHLPESVLQDVIRISRWLVEYGRNQDFMNVYYQIRSSQLDRSIKGLKEHFHKSSSSSGVPYSPAIPNKRKDTPTKKPVKRPGTIRKAQNLLKQYSQHGLDGKKGGSNLIPLEGLLPCTPRGGLPGPWINAACVCAADISPGHEHDFRVKHLSEALNDKHGPLAGRDDMLDVETDAYIHCVSAFVKLAQSEYQLLADIIPEHHQKKTFDSLIQDALDGLMLEGENIVSAARKAIVRHDFSTVLTVFPILRHLKQTKPEFDQVLQGTAASTKNKLPGLITSMETIGAKALEDFADNIKNDPDKEYNMPKDGTVHELTSNAILFLQQLLDFQETAGAMLASQETSSSATSYSSEFSKRLLSTYICKVLGNLQLNLLSKSKVYEDPALSAIFLHNNYNYILKSLEKSELIQLVAVTQKTAERSYREHIEQQIQTYQRSWLKVTDYIAEKNLPVFQPGVKLRDKERQIIKERFKGFNDGLEELCKIQKAWAIPDTEQRDRIRQAQKTIVKETYGAFLQKFGSVPFTKNPEKYIKYGVEQVGDMIDRLFDTSA

Alternative Products

Event=Alternative splicing; Named isoforms=6; Name=3; IsoId=Q9UPT5-3; Sequence=Displayed; Name=1; IsoId=Q9UPT5-1; Sequence=VSP_008878; Name=2; IsoId=Q9UPT5-2; Sequence=VSP_001483; Name=4; IsoId=Q9UPT5-4; Sequence=VSP_008876, VSP_008877; Name=5; IsoId=Q9UPT5-5; Sequence=VSP_041098; Name=6; IsoId=Q9UPT5-6; Sequence=VSP_041099

Alternative Sequence

269..327; Missing (in isoform 5); 271..352; Missing (in isoform 2); 271..283; TIRKAQNLLKQYS -> EPPSWPISATARG (in isoform 4); 284..735; Missing (in isoform 4); 301..328; Missing (in isoform 6); 302..352; Missing (in isoform 1)

Domain & Motif Annotations

Coiled Coil

5..42; 63..85

Domain (CC)

The N-terminus is involved in SEC8 and ARHQ binding.; DOMAIN: The C-terminus is required for translocation to the plasma membrane.

Region

239..268; Disordered

Protein Families

EXO70 family

Sequence Similarities

Belongs to the EXO70 family.

Clinical Relevance5

Disease Involvement

Epilepsy

Antibody (2)

HPA022840 HPA022842

Interaction Protein (12)

ENSG00000070367ENSG00000090989ENSG00000096401ENSG00000105700ENSG00000109083ENSG00000116903ENSG00000131558ENSG00000138190ENSG00000144036ENSG00000146648ENSG00000180104ENSG00000185359

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications1

PMID	Title	Abstract
33919183	Multiple-Cycle Polymeric Extracellular Vesicle Precipitation and Its Evaluation by Targeted Mass Spectrometry.	No abstract available