Protein detail
SHAN2
SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin-binding protein 1) (CortBP1) (Proline-rich synapse-associated protein 1)
Protein symbol SHAN2 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin-binding protein 1) (CortBP1) (Proline-rich synapse-associated protein 1)
Protein Class
Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins
Protein Function
- Disease related genes
- Human disease related genes:Other diseases:Mental and behavioural disorders
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
CORTBP1CTTNBP1ProSAP1SHANKSPANK-3
Gene Description
SH3 and multiple ankyrin repeat domains 2
Chromosome
11
Position
70467854-71252577
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificparathyroid glandCell SpecificAlveolar cells type 1
Function & Pathway
Protein Function
- Disease related genes
- Human disease related genes:Other diseases:Mental and behavioural disorders
- Predicted intracellular proteins
Cellular Component
- GO:0001750 photoreceptor outer segment
- GO:0001917 photoreceptor inner segment
- GO:0005575 cellular_component
- GO:0005829 cytosol
- GO:0005883 neurofilament
- GO:0005886 plasma membrane
- GO:0014069 postsynaptic density
- GO:0016324 apical plasma membrane
- GO:0030426 growth cone
- GO:0031526 brush border membrane
- GO:0043005 neuron projection
- GO:0043025 neuronal cell body
- GO:0043197 dendritic spine
- GO:0045211 postsynaptic membrane
- GO:0048786 presynaptic active zone
- GO:0060170 ciliary membrane
- GO:0098686 hippocampal mossy fiber to CA3 synapse
- GO:0098978 glutamatergic synapse
Molecular Function
Biological Process
Reactome
Mediation Categories
Fusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
16 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | No | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | No | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | No | No |
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Regulatory Interaction Network
6 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| DLGP4 | Q9Y2H0 | SHAN2 | Q9UPX8 | Yes | Yes | No | SIGNOR | SIGNOR:28179641 |
| DLGP1 | O14490 | SHAN2 | Q9UPX8 | Yes | Yes | No | HPRDLit-BM-17SIGNOR | Lit-BM-17:10844022SIGNOR:28179641HPRD:10527873Lit-BM-17:10527873 |
| DLGP2 | Q9P1A6 | SHAN2 | Q9UPX8 | Yes | Yes | No | SIGNOR | SIGNOR:28179641 |
| DLGP3 | O95886 | SHAN2 | Q9UPX8 | Yes | Yes | No | SIGNOR | SIGNOR:28179641 |
| DLGP5 | Q15398 | SHAN2 | Q9UPX8 | Yes | Yes | No | SIGNOR | SIGNOR:28179641 |
| SHAN2 | Q9UPX8 | ACTN1 | P12814 | Yes | Yes | No | SIGNOR | SIGNOR:28179641 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 40222457 |
Sequence, Structure & Domains
Sequences
Length
1,849
Mass
201,261
Sequence
MPRSPTSSEDEMAQSFSDYSVGSESDSSKEETIYDTIRATAEKPGGARTEESQGNTLVIRVVIHDLQQTKCIRFNPDATVWVAKQRILCTLTQSLKDVLNYGLFQPASNGRDGKFLDEERLLREYPQPVGEGVPSLEFRYKKRVYKQASLDEKQLAKLHTKTNLKKCMDHIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYIKNHKETDIVPFREAPAYSNRRRRPPNTLAAPRVLLRSNSDNNLNASAPDWAVCSTATSHRSLSPQLLQQMPSKPEGAAKTIGSYVPGPRSRSPSLNRLGGAGEDGKRPQPLWHVGSPFALGANKDSLSAFEYPGPKRKLYSAVPGRLFVAVKPYQPQVDGEIPLHRGDRVKVLSIGEGGFWEGSARGHIGWFPAECVEEVQCKPRDSQAETRADRSKKLFRHYTVGSYDSFDTSSDCIIEEKTVVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGLRTGDFLIEVNNENVVKVGHRQVVNMIRQGGNHLVLKVVTVTRNLDPDDTARKKAPPPPKRAPTTALTLRSKSMTSELEELVDKASVRKKKDKPEEIVPASKPSRAAENMAVEPRVATIKQRPSSRCFPAGSDMNSVYERQGIAVMTPTVPGSPKAPFLGIPRGTMRRQKSIDSRIFLSGITEEERQFLAPPMLKFTRSLSMPDTSEDIPPPPQSVPPSPPPPSPTTYNCPKSPTPRVYGTIKPAFNQNSAAKVSPATRSDTVATMMREKGMYFRRELDRYSLDSEDLYSRNAGPQANFRNKRGQMPENPYSEVGKIASKAVYVPAKPARRKGMLVKQSNVEDSPEKTCSIPIPTIIVKEPSTSSSGKSSQGSSMEIDPQAPEPPSQLRPDESLTVSSPFAAAIAGAVRDREKRLEARRNSPAFLSTDLGDEDVGLGPPAPRTRPSMFPEEGDFADEDSAEQLSSPMPSATPREPENHFVGGAEASAPGEAGRPLNSTSKAQGPESSPAVPSASSGTAGPGNYVHPLTGRLLDPSSPLALALSARDRAMKESQQGPKGEAPKADLNKPLYIDTKMRPSLDAGFPTVTRQNTRGPLRRQETENKYETDLGRDRKGDDKKNMLIDIMDTSQQKSAGLLMVHTVDATKLDNALQEEDEKAEVEMKPDSSPSEVPEGVSETEGALQISAAPEPTTVPGRTIVAVGSMEEAVILPFRIPPPPLASVDLDEDFIFTEPLPPPLEFANSFDIPDDRAASVPALSDLVKQKKSDTPQSPSLNSSQPTNSADSKKPASLSNCLPASFLPPPESFDAVADSGIEEVDSRSSSDHHLETTSTISTVSSISTLSSEGGENVDTCTVYADGQAFMVDKPPVPPKPKMKPIIHKSNALYQDALVEEDVDSFVIPPPAPPPPPGSAQPGMAKVLQPRTSKLWGDVTEIKSPILSGPKANVISELNSILQQMNREKLAKPGEGLDSPMGAKSASLAPRSPEIMSTISGTRSTTVTFTVRPGTSQPITLQSRPPDYESRTSGTRRAPSPVVSPTEMNKETLPAPLSAATASPSPALSDVFSLPSQPPSGDLFGLNPAGRSRSPSPSILQQPISNKPFTTKPVHLWTKPDVADWLESLNLGEHKEAFMDNEIDGSHLPNLQKEDLIDLGVTRVGHRMNIERALKQLLDR
Alternative Products
Event=Alternative splicing; Named isoforms=4; Comment=Additional isoforms seem to exist.; Name=3; Synonyms=E; IsoId=Q9UPX8-3; Sequence=Displayed; Name=1; Synonyms=A; IsoId=Q9UPX8-1; Sequence=VSP_061471; Name=2; Synonyms=C; IsoId=Q9UPX8-2; Sequence=VSP_061470, VSP_061473, VSP_061474; Name=4; Synonyms=B; IsoId=Q9UPX8-4; Sequence=VSP_061470, VSP_061472
Alternative Sequence
1..617; MPRSPTSSEDEMAQSFSDYSVGSESDSSKEETIYDTIRATAEKPGGARTEESQGNTLVIRVVIHDLQQTKCIRFNPDATVWVAKQRILCTLTQSLKDVLNYGLFQPASNGRDGKFLDEERLLREYPQPVGEGVPSLEFRYKKRVYKQASLDEKQLAKLHTKTNLKKCMDHIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYIKNHKETDIVPFREAPAYSNRRRRPPNTLAAPRVLLRSNSDNNLNASAPDWAVCSTATSHRSLSPQLLQQMPSKPEGAAKTIGSYVPGPRSRSPSLNRLGGAGEDGKRPQPLWHVGSPFALGANKDSLSAFEYPGPKRKLYSAVPGRLFVAVKPYQPQVDGEIPLHRGDRVKVLSIGEGGFWEGSARGHIGWFPAECVEEVQCKPRDSQAETRADRSKKLFRHYTVGSYDSFDTS -> MMMNVPGGGAAAVMMTGYNNGRCPRNSLY (in isoform 2 and isoform 4); 1..391; MPRSPTSSEDEMAQSFSDYSVGSESDSSKEETIYDTIRATAEKPGGARTEESQGNTLVIRVVIHDLQQTKCIRFNPDATVWVAKQRILCTLTQSLKDVLNYGLFQPASNGRDGKFLDEERLLREYPQPVGEGVPSLEFRYKKRVYKQASLDEKQLAKLHTKTNLKKCMDHIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYIKNHKETDI -> MKSLLNAFTKKE (in isoform 1); 763..769; Missing (in isoform 4); 851..869; DSRIFLSGITEEERQFLAP -> GKKCGTPPQKLPLGFQTQP (in isoform 2); 870..1849; Missing (in isoform 2)
3D Structural Models
Turn
1814..1816
Helix
1783..1785; 1788..1797; 1801..1803; 1804..1809; 1817..1819; 1822..1827; 1833..1845
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
15..25; Low complexity; 764..774; Basic and acidic residues; 887..903; Pro residues; 1040..1052; Low complexity; 1086..1097; Basic and acidic residues; 1128..1138; Acidic residues; 1159..1170; Low complexity; 1181..1199; Low complexity; 1208..1221; Low complexity; 1274..1293; Basic and acidic residues; 1343..1357; Low complexity; 1445..1460; Polar residues; 1494..1505; Basic and acidic residues; 1506..1522; Low complexity; 1577..1588; Pro residues; 1678..1692; Polar residues; 1721..1738; Low complexity; 1760..1774; Low complexity
Repeat
196..226; ANK 1; 230..259; ANK 2; 263..293; ANK 3; 297..326; ANK 4; 330..359; ANK 5; 363..393; ANK 6
Motif
1327..1333; SH3-binding
Domain (CC)
The PDZ domain is required for interaction with GRID2, PLCB3, CFTR and SLC9A3..
Domain (FT)
526..585; SH3; 626..720; PDZ; 1786..1849; SAM
Region
1..33; Disordered; 451..493; Disordered; 764..808; Disordered; 878..910; Disordered; 1013..1293; Disordered; 1328..1371; Disordered; 1432..1526; Disordered; 1574..1594; Disordered; 1678..1776; Disordered
Protein Families
SHANK family
Sequence Similarities
Belongs to the SHANK family.