Protein detail

COR2B

Coronin-2B (Coronin-like protein C) (Clipin-C) (Protein FC96)

Entry name COR2B	UniProt ID Q9UQ03	EVMP confidence score 0.38
Supporting publications (n) 2	Transmembrane count	Protein classification Plasma proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Coronin-2B (Coronin-like protein C) (Clipin-C) (Protein FC96)

Protein Class (2)

Plasma proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000103647

Entrez Gene Symbol

CORO2B

Gene Synonym (2)

ClipinCKIAA0925

Gene Description

Coronin 2B

Chromosome

Position

68578993-68727806

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization3

Tissue SpecificbrainCell SpecificAstrocytesSingle-Nuclei Brain Specificoligodendrocyte

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (4)

Molecular Function (5)

Biological Process (3)

Canonical Pathways

M206 Pid pdgfra pathway

Mediation Categories (2)

Adhesion and uptake mediationFusion and delivery mediation

Relations & Evidence5

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	20	31196968 33718342 34622320 39290459 39949490 40928027 31508500 38225453 39873726 38731868 26801919 26884841 33709510 36362114 24657793 38490958 30760538 40311616 40091455 31320591

Sequence, Structure & Domains9

Sequences

Length

480

Mass

54,953

Sequence

MTVTKMSWRPQYRSSKFRNVYGKVANREHCFDGIPITKNVHDNHFCAVNTRFLAIVTESAGGGSFLVIPLEQTGRIEPNYPKVCGHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEALLELHGHSRRVGLVEWHPTTNNILFSAGYDYKVLIWNLDVGEPVKMIDCHTDVILCMSFNTDGSLLTTTCKDKKLRVIEPRSGRVLQEANCKNHRVNRVVFLGNMKRLLTTGVSRWNTRQIALWDQEDLSMPLIEEEIDGLSGLLFPFYDADTHMLYLAGKGDGNIRYYEISTEKPYLSYLMEFRSPAPQKGLGVMPKHGLDVSACEVFRFYKLVTLKGLIEPISMIVPRRSDSYQEDIYPMTPGTEPALTPDEWLGGINRDPVLMSLKEGYKKSSKMVFKAPIKEKKSVVVNGIDLLENVPPRTENELLRMFFRQQDEIRRLKEELAQKDIRIRQLQLELKNLRNSPKNC

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UQ03-1; Sequence=Displayed; Name=2; IsoId=Q9UQ03-2; Sequence=VSP_037706

Alternative Sequence

1..6; MTVTKM -> M (in isoform 2)

Domain & Motif Annotations

Repeat

29..77; WD 1; 78..127; WD 2; 128..170; WD 3; 171..212; WD 4; 213..259; WD 5; 260..305; WD 6; 306..345; WD 7

Coiled Coil

436..479

Protein Families

WD repeat coronin family

Sequence Similarities

Belongs to the WD repeat coronin family.

Clinical Relevance1

Antibody

HPA017960

Supporting Publications2

PMID	Title	Abstract
38395386	Human gestational diabetes mellitus-derived exosomes impair glucose homeostasis in pregnant mice and stimulate functional maturation of offspring-islets.	No abstract available
38589887	The protein composition of exosomes released by prostate cancer cells is distinctly regulated by androgen receptor-antagonists and -agonist to stimulate growth of target cells.	AR ligands augment hub factors in exosomes that include AKT1, CALM1, PAK2 and CTNND1.