Protein detail

BAIP2

BAR/IMD domain-containing adapter protein 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2) (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58) (IRS-58) (IRSp53/58) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53)

Entry name BAIP2	UniProt ID Q9UQB8	EVMP confidence score 0.40
Supporting publications (n) 1	Transmembrane count	Protein classification Plasma proteinsPredicted intracellular proteins

Basic Information

Protein Names

Protein Class (2)

Plasma proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000175866

Entrez Gene Symbol

BAIAP2

Gene Synonym (3)

BAP2IRSp53WAML

Gene Description

BAR/IMD domain containing adaptor protein 2

Chromosome

Position

81035122-81117434

Supporting publications (n)

EVMP confidence score

0.40

Fluorescence & Localization

Tissue Specificlymphoid tissueCell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophage

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component (24)

Page 1 of 3

Molecular Function (8)

Biological Process (3)

KEGG (5)

Reactome (14)

Page 1 of 2

Canonical Pathways (3)

M5880 Naba ecm affiliated
M5885 Naba matrisome associated
M5889 Naba matrisome

Mediation Categories (5)

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence29

Enzyme-Mediated Modification (10)

10 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
BAIAP2	PRKAA1	Q13131	S	366	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:19933840 SIGNOR:19933840 ProtMapper:22137581 SIGNOR:22137581
BAIAP2	PRKAA2	P54646	S	366	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:19933840 SIGNOR:19933840 ProtMapper:22137581 SIGNOR:22137581
BAIAP2	PRKAG1	P54619	S	366	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:19933840 SIGNOR:19933840 ProtMapper:22137581 SIGNOR:22137581
BAIAP2	PRKAB2	O43741	S	366	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:19933840 SIGNOR:19933840 ProtMapper:22137581 SIGNOR:22137581
BAIAP2	PRKAG3	Q9UGI9	S	366	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:19933840 SIGNOR:19933840 ProtMapper:22137581 SIGNOR:22137581
BAIAP2	PRKAB1	Q9Y478	S	366	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:19933840 SIGNOR:19933840 ProtMapper:22137581 SIGNOR:22137581
BAIAP2	PRKAG2	Q9UGJ0	S	366	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:19933840 SIGNOR:19933840 ProtMapper:22137581 SIGNOR:22137581
BAIAP2	MARK2	Q7KZI7	S	366	phosphorylation	Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:21282462
BAIAP2	MARK2	Q7KZI7	S	325	phosphorylation	REACH_ProtMapperProtMapper	ProtMapper:21282462
BAIAP2	IGF1R	P08069	Y	506	phosphorylation	KEA	KEA:17570479

Ligand-Receptor Signaling (5)

5 records.

Category	Parent	Database
intracellular	intracellular	LOCATE
intracellular	intracellular	ComPPI
intracellular	intracellular	GO_Intercell
intracellular	intracellular	UniProt_location
intracellular	intracellular	OmniPath

Regulatory Interaction Network (9)

9 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
BAIP2	Q9UQB8	WASF2	Q9Y6W5	Yes	Yes		DOMINOWangSIGNORHPRDHINTACSNSPIKE_LCLit-BM-17	SIGNOR:11130076 ACSN:12054568 HPRD:12054568 Lit-BM-17:26186194 HINT:35271311 ACSN:16702231 Lit-BM-17:11130076 DOMINO:11130076 Lit-BM-17:26496610 SPIKE_LC:11130076 HINT:11130076 SPIKE_LC:16713569 HINT:33961781 HPRD:11130076 HINT:26496610 ACSN:9843499
AAPK2	P54646	BAIP2	Q9UQB8	Yes		Yes	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperSIGNOR_ProtMapperPhosphoSite_ProtMapper	ProtMapper:19933840 SIGNOR:19933840 ProtMapper:22137581 SIGNOR:22137581
MARK2	Q7KZI7	BAIP2	Q9UQB8	Yes		Yes	Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	SIGNOR:21282462 PhosphoSite:21282462 ProtMapper:21282462
BAIP2	Q9UQB8	WASF1	Q92558	Yes	Yes		WangSIGNORHINTIntActSPIKE_LCLit-BM-17	SIGNOR:11130076 HINT:35271311 IntAct:11130076 HINT:11130076 SPIKE_LC:16713569 Lit-BM-17:11130076 HINT:33961781
RAC1	P63000	BAIP2	Q9UQB8	Yes	Yes		WangSIGNORHPRDHINTACSNIntActSPIKE_LC	SIGNOR:11130076 ACSN:11152757 ACSN:12480336 ACSN:16212495 HINT:11696321 HPRD:19171758 SPIKE_LC:11130076 HPRD:11130076 ACSN:9843499 HINT:19171758 IntAct:17003044 ACSN:16702231 HINT:11130076 ACSN:12054568 HPRD:12054568 SIGNOR:19171758 SPIKE_LC:16713569 IntAct:11696321 HINT:17003044
	COMPLEX:O43741_P54619_P54646_Q13131_Q9UGI9_Q9UGJ0_Q9Y478	BAIP2	Q9UQB8	Yes		Yes	SIGNOR	SIGNOR:19933840 SIGNOR:22137581
CDC42	P60953	BAIP2	Q9UQB8	Yes	Yes		SIGNORHPRDHINTBioGRIDIntActDIPSPIKE_LCLit-BM-17	HINT:24584464 IntAct:19171758 Lit-BM-17:11157984 HINT:31478661 SIGNOR:11696321 HINT:11696321 HINT:12504591 HINT:21311754 DIP:24584464 Lit-BM-17:24076653 Lit-BM-17:11696321 BioGRID:17430976 IntAct:24584464 HINT:11157984 HINT:11130076 IntAct:24076653 HPRD:11696321 SPIKE_LC:16713569 Lit-BM-17:20936779 Lit-BM-17:11130076 Lit-BM-17:12504591
BAIP2	Q9UQB8	ENAH	Q8N8S7	Yes	Yes		HPRDWangSIGNOR	SIGNOR:11696321 HPRD:11696321
KANK1	Q14678	BAIP2	Q9UQB8	Yes		Yes	HPRDSIGNORIntAct	HPRD:19171758 SIGNOR:19171758 IntAct:19171758

Protein Complex Composition (4)

4 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
BAIAP2 YWHAQ	P27348 Q9UQB8	4:4	PDB	PDB:6bd2PDB:6bqtPDB:6bd1PDB:6bcyPDB:6bcr
BAIAP2 CDC42	P60953 Q9UQB8	1:1	PDB	PDB:4js0
BAIAP2 CHMP6	Q96FZ7 Q9UQB8	0:0	hu.MAP
BAIAP2	Q9UQB8	2	PDB	PDB:1y2oPDB:1wdz

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Western blottingELISA	3	26775013 40098346 37922300

Sequence, Structure & Domains

Sequences

Length

552

Mass

60,868

Sequence

MSLSRSEEMHRLTENVYKTIMEQFNPSLRNFIAMGKNYEKALAGVTYAAKGYFDALVKMGELASESQGSKELGDVLFQMAEVHRQIQNQLEEMLKSFHNELLTQLEQKVELDSRYLSAALKKYQTEQRSKGDALDKCQAELKKLRKKSQGSKNPQKYSDKELQYIDAISNKQGELENYVSDGYKTALTEERRRFCFLVEKQCAVAKNSAAYHSKGKELLAQKLPLWQQACADPSKIPERAVQLMQQVASNGATLPSALSASKSNLVISDPIPGAKPLPVPPELAPFVGRMSAQESTPIMNGVTGPDGEDYSPWADRKAAQPKSLSPPQSQSKLSDSYSNTLPVRKSVTPKNSYATTENKTLPRSSSMAAGLERNGRMRVKAIFSHAAGDNSTLLSFKEGDLITLLVPEARDGWHYGESEKTKMRGWFPFSYTRVLDSDGSDRLHMSLQQGKSSSTGNLLDKDDLAIPPPDYGAASRAFPAQTASGFKQRPYSVAVPAFSQGLDDYGARSMSRNPFAHVQLKPTVTNDRCDLSAQGPEGREHGDGSARTLAGR

Alternative Products

Event=Alternative splicing; Named isoforms=6; Name=1; Synonyms=IRSp53(L); IsoId=Q9UQB8-1; Sequence=Displayed; Name=2; IsoId=Q9UQB8-2; Sequence=VSP_015506; Name=3; IsoId=Q9UQB8-3; Sequence=VSP_015505; Name=4; Synonyms=BAIAP2-alpha; IsoId=Q9UQB8-4; Sequence=VSP_015503; Name=5; Synonyms=BAIAP2-beta; IsoId=Q9UQB8-5; Sequence=VSP_015504; Name=6; IsoId=Q9UQB8-6; Sequence=VSP_015502, VSP_015503

Alternative Sequence

356; T -> TA (in isoform 6); 512..552; RNPFAHVQLKPTVTNDRCDLSAQGPEGREHGDGSARTLAGR -> SGSGTLVSTV (in isoform 4 and isoform 6); 512..552; RNPFAHVQLKPTVTNDRCDLSAQGPEGREHGDGSARTLAGR -> SADVEVARF (in isoform 5); 513..552; Missing (in isoform 3); 529..552; CDLSAQGPEGREHGDGSARTLAGR -> SAPLLS (in isoform 2)

3D Structural Models

Turn

99..101; 154..157; 419..421; 458..460

Helix

5..22; 24..64; 70..98; 102..146; 150..152; 159..228; 238..246; 281..286; 429..431

Beta Strand

66..68; 378..383; 401..404; 406..408; 413..418; 424..428; 432..434

3D Structure

X-ray crystallography (12)

Domain & Motif Annotations

Compositional Bias

320..334; Low complexity; 348..367; Polar residues; 447..457; Polar residues

Coiled Coil

132..153

Domain (CC)

The IMD domain forms a coiled coil. The isolated domain can induce actin bundling and filopodia formation. In the absence of G-proteins intramolecular interaction between the IMD and the SH3 domain gives rise to an auto-inhibited state of the protein. Interaction of the IMD with RAC1 or CDC42 leads to activation.; DOMAIN: The SH3 domain interacts with ATN1, ADGRB1, WASF1, WASF2, SHANK1, DIAPH1 and ENAH.

Domain (FT)

1..250; IMD; 374..437; SH3

Region

295..369; Disordered; 447..466; Disordered; 525..552; Disordered

Clinical Relevance

Antibody (2)

HPA023310 HPA027421

Interaction Protein (24)

ENSG00000006453ENSG00000055163ENSG00000061676ENSG00000070831ENSG00000075624ENSG00000106299ENSG00000108953ENSG00000111676ENSG00000112290ENSG00000128245ENSG00000133703ENSG00000134308ENSG00000136238ENSG00000136754ENSG00000138443ENSG00000146648ENSG00000151491ENSG00000158195ENSG00000162522ENSG00000164924ENSG00000166913ENSG00000170027ENSG00000213672ENSG00000254999

Interaction Count

Interaction Dataset (3)

intact_biogrid_opencellbiogrid_opencellintact_biogrid

Supporting Publications1

PMID	Title	Related sentences
40189497	Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis.	No related sentences available