Protein detail
GAB2
GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100)
Protein symbol GAB2 | UniProt ID | EVMP score 0.50 |
Frequency 5 | Transmembrane count | Protein classification Predicted intracellular proteinsRAS pathway related proteins |
Basic Information
Protein Names
GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100)
Protein Class
Predicted intracellular proteinsRAS pathway related proteins
Protein Function
- Predicted intracellular proteins
- RAS pathway related proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
KIAA0571
Gene Description
GRB2 associated binding protein 2
Chromosome
11
Position
78215293-78418348
Frequency
5
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificBergmann glia
Function & Pathway
Protein Function
- Predicted intracellular proteins
- RAS pathway related proteins
Cellular Component
Molecular Function
Biological Process
- GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
- GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib
- GO:0002484 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway
KEGG
Reactome
- R-hsa-2219530 constitutive signaling by aberrant pi3k in cancer
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-5663202 diseases of signal transduction by growth factor receptors and second messengers
- R-hsa-2454202 fc epsilon receptor fceri signaling
- R-hsa-1839124 fgfr1 mutant receptor activation
- R-hsa-9607240 flt3 signaling
- R-hsa-9682385 flt3 signaling in disease
- R-hsa-168249 innate immune system
- R-hsa-74751 insulin receptor signalling cascade
- R-hsa-8983432 interleukin 15 signaling
- R-hsa-451927 interleukin 2 family signaling
- R-hsa-512988 interleukin 3 interleukin 5 and gm csf signaling
- R-hsa-912526 interleukin receptor shc signaling
- R-hsa-9006925 intracellular signaling by second messengers
- R-hsa-112399 irs mediated signalling
- R-hsa-199418 negative regulation of the pi3k akt network
- R-hsa-9675108 nervous system development
- R-hsa-2219528 pi3k akt signaling in cancer
- R-hsa-8853659 ret signaling
- R-hsa-2730905 role of lat2 ntal lab on calcium mobilization
- R-hsa-9680350 signaling by csf1 m csf in myeloid cells
- R-hsa-9674555 signaling by csf3 g csf
- R-hsa-1839117 signaling by cytosolic fgfr1 fusion mutants
- R-hsa-5655302 signaling by fgfr1 in disease
- R-hsa-1226099 signaling by fgfr in disease
- R-hsa-9703465 signaling by flt3 fusion proteins
- R-hsa-9703648 signaling by flt3 itd and tkd mutants
- R-hsa-74752 signaling by insulin receptor
- R-hsa-449147 signaling by interleukins
- R-hsa-9006934 signaling by receptor tyrosine kinases
- R-hsa-1433557 signaling by scf kit
- R-hsa-2404192 signaling by type 1 insulin like growth factor 1 receptor igf1r
- R-hsa-9645135 stat5 activation
- R-hsa-9702518 stat5 activation downstream of flt3 itd mutants
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
24 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| GAB2 | ZAP70 | P43403 | Y | 614 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:15170389HPRD:11572860KEA:11572860SIGNOR:11572860phosphoELM:11572860ProtMapper:11572860 |
| GAB2 | ZAP70 | P43403 | Y | 452 | phosphorylation | Sparser_ProtMapperProtMapper | |
| GAB2 | ZAP70 | P43403 | Y | 576 | phosphorylation | KEA | KEA:11572860 |
| GAB2 | MAPK3 | P27361 | S | 623 | phosphorylation | PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | HPRD:15356145phosphoELM:15356145KEA:15356145ProtMapper:15356145SIGNOR:15356145 |
| GAB2 | MAPK3 | P27361 | S | 141 | phosphorylation | PhosphoNetworks | |
| GAB2 | MAPK3 | P27361 | S | 480 | phosphorylation | PhosphoNetworks | |
| GAB2 | MAPK3 | P27361 | S | 543 | phosphorylation | PhosphoNetworks | |
| GAB2 | MAPK3 | P27361 | S | 585 | phosphorylation | KEA | KEA:15356145 |
| GAB2 | PTPN11 | Q06124 | Y | 614 | dephosphorylation | SIGNOR | SIGNOR:15170389 |
| GAB2 | PTPN11 | Q06124 | Y | 614 | phosphorylation | SIGNOR_ProtMapperProtMapper | ProtMapper:15170389 |
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Ligand-Receptor Signaling
7 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
15 records.
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Protein Complex Composition
6 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| GAB2GAREM1GRAP2USP8 | O75791P40818Q9H706Q9UQC2 | 0:0:0:0 | hu.MAP | |||
| GAB2GAREM1GRAP2PTPN23 | O75791Q9H3S7Q9H706Q9UQC2 | 0:0:0:0 | hu.MAP | |||
| DDHD2GAB2TGM4 | O94830P49221Q9UQC2 | 0:0:0 | hu.MAP2 | |||
| GAB2SFN | P31947Q9UQC2 | 1:1 | PDB | PDB:6zvbPDB:6y3rPDB:6y3sPDB:6zvdPDB:6zvePDB:6zvc | ||
| GAB2GRB2 | P62993Q9UQC2 | 1:1 | PDB | PDB:2w0zPDB:2vwf | ||
| GAB2YWHAZ | P63104Q9UQC2 | 2:2 | PDB | PDB:5exaPDB:5ewz |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry [LTQ-FT Ultra]Mass spectrometry | 1 | 40222457 |
Sequence, Structure & Domains
Sequences
Length
676
Mass
74,458
Sequence
MSGGGDVVCTGWLRKSPPEKKLRRYAWKKRWFILRSGRMSGDPDVLEYYKNDHSKKPLRIINLNFCEQVDAGLTFNKKELQDSFVFDIKTSERTFYLVAETEEDMNKWVQSICQICGFNQAEESTDSLRNVSSAGHGPRSSPAELSSSSQHLLRERKSSAPSHSSQPTLFTFEPPVSNHMQPTLSTSAPQEYLYLHQCISRRAENARSASFSQGTRASFLMRSDTAVQKLAQGNGHCVNGISGQVHGFYSLPKPSRHNTEFRDSTYDLPRSLASHGHTKGSLTGSETDNEDVYTFKTPSNTLCREFGDLLVDNMDVPATPLSAYQIPRTFTLDKNHNAMTVATPGDSAIAPPPRPPKPSQAETPRWGSPQQRPPISENSRSVAATIPRRNTLPAMDNSRLHRASSCETYEYPQRGGESAGRSAESMSDGVGSFLPGKMIVGRSDSTNSEDNYVPMNPGSSTLLAMERAGDNSQSVYIPMSPGAHHFDSLGYPSTTLPVHRGPSRGSEIQPPPVNRNLKPDRKAKPTPLDLRNNTVIDELPFKSPITKSWSRANHTFNSSSSQYCRPISTQSITSTDSGDSEENYVPMQNPVSASPVPSGTNSPAPKKSTGSVDYLALDFQPSSPSPHRKPSTSSVTSDEKVDYVQVDKEKTQALQNTMQEWTDVRQSSEPSKGAKL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UQC2-1; Sequence=Displayed; Name=2; IsoId=Q9UQC2-2; Sequence=VSP_038520
Alternative Sequence
1..38; Missing (in isoform 2)
3D Structural Models
Helix
515..517
3D Structure
X-ray crystallography (10)
Domain & Motif Annotations
Compositional Bias
140..149; Low complexity; 159..169; Polar residues; 556..577; Polar residues; 589..611; Polar residues; 656..670; Polar residues
Motif
351..358; SH3-binding; 510..519; SH3-binding
Domain (CC)
The SH3-binding motifs mediate interaction with SHC1 and GRB2..; DOMAIN: The PH domain mediates phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,4-bisphosphate binding.
Domain (FT)
6..117; PH
Region
127..178; Disordered; 341..430; Disordered; 492..531; Disordered; 556..643; Disordered; 656..676; Disordered
Protein Families
GAB family
Sequence Similarities
Belongs to the GAB family.