Protein detail
GAB2
GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100)
Entry name GAB2 | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 5 | Transmembrane count | Protein classification Predicted intracellular proteinsRAS pathway related proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100)
Protein Class (2)
Predicted intracellular proteinsRAS pathway related proteins
Protein Function (2)
- Predicted intracellular proteins
- RAS pathway related proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
KIAA0571
Gene Description
GRB2 associated binding protein 2
Chromosome
11
Position
78215293-78418348
Supporting publications (n)
5
EVMP confidence score
0.53
Fluorescence & Localization
Cell SpecificBergmann glia
Function & Pathway
Protein Function (2)
- Predicted intracellular proteins
- RAS pathway related proteins
Cellular Component (4)
Molecular Function (4)
Biological Process (3)
- GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
- GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib
- GO:0002484 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway
KEGG (7)
Reactome (34)
- R-hsa-2219530 constitutive signaling by aberrant pi3k in cancer
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-5663202 diseases of signal transduction by growth factor receptors and second messengers
- R-hsa-2454202 fc epsilon receptor fceri signaling
- R-hsa-1839124 fgfr1 mutant receptor activation
- R-hsa-9607240 flt3 signaling
- R-hsa-9682385 flt3 signaling in disease
- R-hsa-168249 innate immune system
- R-hsa-74751 insulin receptor signalling cascade
- R-hsa-8983432 interleukin 15 signaling
Page 1 of 4
Mediation Categories (4)
Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence53
Enzyme-Mediated Modification (24)
24 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| GAB2 | AKT1 | P31749 | S | 159 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:11782427SIGNOR:11782427ProtMapper:11782427HPRD:11782427 |
| GAB2 | AKT1 | P31749 | S | 121 | phosphorylation | KEA | KEA:11782427 |
| GAB2 | JAK2 | O60674 | Y | 643 | phosphorylation | Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:18644434ProtMapper:18644434 |
| GAB2 | JAK2 | O60674 | Y | 452 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:21183952 |
| GAB2 | MAPK1 | P28482 | S | 623 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:15356145KEA:15356145SIGNOR:15356145HPRD:15356145 |
| GAB2 | MAPK1 | P28482 | S | 585 | phosphorylation | KEA | KEA:15356145 |
| GAB2 | SRC | P12931 | Y | 476 | phosphorylation | Li2012 | |
| GAB2 | SYK | P43405 | Y | 614 | phosphorylation | Li2012 | |
| GAB2 | PDK1 | Q15118 | S | 159 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| GAB2 | CSF3 | P09919 | Y | 643 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:18644434 |
Ligand-Receptor Signaling (7)
7 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | |||||
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| plasma_membrane | plasma_membrane | UniProt_location | |||||
| plasma_membrane | plasma_membrane | OmniPath |
Regulatory Interaction Network (15)
15 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| GAB2 | Q9UQC2 | LCP2 | Q13094 | Yes | Yes | SignaLink3TCRcuration_SignaLink3 | SignaLink3:23109003SignaLink3:15286727SignaLink3:12640133SignaLink3:11323691 | |
| JAK2 | O60674 | GAB2 | Q9UQC2 | Yes | Yes | WangSparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefSIGNORiPTMnetProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSite_ProtMapper | SIGNOR:18644434ProtMapper:18644434ProtMapper:21183952 | |
| AKT1 | P31749 | GAB2 | Q9UQC2 | Yes | Yes | HPRD_MIMPSIGNORProtMapperHINTPhosphoSite_KEAInnateDBHPRDKinexus_KEAPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEASIGNOR_ProtMapperPhosphoSiteHPRD-phos | KEA:11782427ProtMapper:11782427HPRD:11782427SIGNOR:11782427HPRD-phos:11782427HINT:34941261PhosphoSite:11782427HINT:11782427InnateDB:11782427 | |
| GAB2 | Q9UQC2 | PK3CA | P42336 | Yes | Yes | WangSIGNOR | SIGNOR:24737791 | |
| GAB2 | Q9UQC2 | COMPLEX:P27986_P42336 | Yes | Yes | SIGNOR | SIGNOR:24737791 |
Page 2 of 2Previous
Protein Complex Composition (6)
6 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| GAB2GAREM1GRAP2USP8 | O75791P40818Q9H706Q9UQC2 | 0:0:0:0 | hu.MAP | |||
| GAB2GAREM1GRAP2PTPN23 | O75791Q9H3S7Q9H706Q9UQC2 | 0:0:0:0 | hu.MAP | |||
| DDHD2GAB2TGM4 | O94830P49221Q9UQC2 | 0:0:0 | hu.MAP2 | |||
| GAB2SFN | P31947Q9UQC2 | 1:1 | PDB | PDB:6zvbPDB:6y3rPDB:6y3sPDB:6zvdPDB:6zvePDB:6zvc | ||
| GAB2GRB2 | P62993Q9UQC2 | 1:1 | PDB | PDB:2w0zPDB:2vwf | ||
| GAB2YWHAZ | P63104Q9UQC2 | 2:2 | PDB | PDB:5exaPDB:5ewz |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry [LTQ-FT Ultra]Mass spectrometry | 1 | 40222457 |
Sequence, Structure & Domains
Sequences
Length
676
Mass
74,458
Sequence
MSGGGDVVCTGWLRKSPPEKKLRRYAWKKRWFILRSGRMSGDPDVLEYYKNDHSKKPLRIINLNFCEQVDAGLTFNKKELQDSFVFDIKTSERTFYLVAETEEDMNKWVQSICQICGFNQAEESTDSLRNVSSAGHGPRSSPAELSSSSQHLLRERKSSAPSHSSQPTLFTFEPPVSNHMQPTLSTSAPQEYLYLHQCISRRAENARSASFSQGTRASFLMRSDTAVQKLAQGNGHCVNGISGQVHGFYSLPKPSRHNTEFRDSTYDLPRSLASHGHTKGSLTGSETDNEDVYTFKTPSNTLCREFGDLLVDNMDVPATPLSAYQIPRTFTLDKNHNAMTVATPGDSAIAPPPRPPKPSQAETPRWGSPQQRPPISENSRSVAATIPRRNTLPAMDNSRLHRASSCETYEYPQRGGESAGRSAESMSDGVGSFLPGKMIVGRSDSTNSEDNYVPMNPGSSTLLAMERAGDNSQSVYIPMSPGAHHFDSLGYPSTTLPVHRGPSRGSEIQPPPVNRNLKPDRKAKPTPLDLRNNTVIDELPFKSPITKSWSRANHTFNSSSSQYCRPISTQSITSTDSGDSEENYVPMQNPVSASPVPSGTNSPAPKKSTGSVDYLALDFQPSSPSPHRKPSTSSVTSDEKVDYVQVDKEKTQALQNTMQEWTDVRQSSEPSKGAKL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UQC2-1; Sequence=Displayed; Name=2; IsoId=Q9UQC2-2; Sequence=VSP_038520
Alternative Sequence
1..38; Missing (in isoform 2)
3D Structural Models
Helix
515..517
3D Structure
X-ray crystallography (10)
Domain & Motif Annotations
Compositional Bias
140..149; Low complexity; 159..169; Polar residues; 556..577; Polar residues; 589..611; Polar residues; 656..670; Polar residues
Motif
351..358; SH3-binding; 510..519; SH3-binding
Domain (CC)
The SH3-binding motifs mediate interaction with SHC1 and GRB2..; DOMAIN: The PH domain mediates phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,4-bisphosphate binding.
Domain (FT)
6..117; PH
Region
127..178; Disordered; 341..430; Disordered; 492..531; Disordered; 556..643; Disordered; 656..676; Disordered
Protein Families
GAB family
Sequence Similarities
Belongs to the GAB family.
Clinical Relevance
Supporting Publications5
| PMID | Title | Related sentences |
|---|---|---|
| 28986585 | Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics. | No related sentences available |
| 30646616 | Preferential Localization of MUC1 Glycoprotein in Exosomes Secreted by Non-Small Cell Lung Carcinoma Cells. | THBS1, ANXA6, HIST1H4A, COL18A1, MDK, SRGN, ENO1, TUBA4A, SLC3A2, GPI, MIF, MUC1, TALDO1, SLC7A5, ICAM1, HSP90AA1, G6PD, and LRP1 were found to be expressed in exosomes at more than 5-fold higher level as compared to total cellular membrane proteins. |
| 30950185 | Unique Protein Profiles of Extracellular Vesicles as Diagnostic Biomarkers for Early and Advanced Non-Small Cell Lung Cancer. | No related sentences available |
| 34817906 | Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform. | No related sentences available |
| 37786918 | Rapid and in-depth proteomic profiling of small extracellular vesicles for ultralow samples. | No related sentences available |