Protein detail

JIP1

C-Jun-amino-terminal kinase-interacting protein 1 (JIP-1) (JNK-interacting protein 1) (Islet-brain 1) (IB-1) (JNK MAP kinase scaffold protein 1) (Mitogen-activated protein kinase 8-interacting protein 1)

Entry name JIP1	UniProt ID Q9UQF2	EVMP score 0.50
Frequency 1	Transmembrane count	Protein classification Cancer-related genesDisease related genesPlasma proteinsPredicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Protein Class

Cancer-related genesDisease related genesPlasma proteinsPredicted intracellular proteins

Protein Function

Cancer-related genes:Mutational cancer driver genes
Disease related genes
Predicted intracellular proteins

Ensembl

ENSG00000121653

Entrez Gene Symbol

MAPK8IP1

Gene Synonym

IB1JIP-1JIP1PRKM8IP

Gene Description

Mitogen-activated protein kinase 8 interacting protein 1

Chromosome

Position

45885651-45906465

Frequency

EVMP Score

0.50

Fluorescence & Localization

Function & Pathway

Protein Function

Cancer-related genes:Mutational cancer driver genes
Disease related genes
Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

KEGG

hsa04010 MAPK signaling pathway

Mediation Categories

Clinical-translation mediationImmune mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

36 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
MAPK8IP1	MAPK9	P45984	S	15	phosphorylation	PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPKEA	KEA:12756254
MAPK8IP1	MAPK9	P45984	S	29	phosphorylation	PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPKEA	KEA:12756254
MAPK8IP1	MAPK9	P45984	T	205	phosphorylation	PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPKEA	KEA:12756254
MAPK8IP1	MAPK9	P45984	T	284	phosphorylation	PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPKEA	KEA:12756254
MAPK8IP1	MAPK9	P45984	S	341	phosphorylation	PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPKEA	KEA:12756254
MAPK8IP1	MAPK9	P45984	S	197	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPKEA	KEA:12756254
MAPK8IP1	MAPK9	P45984	S	421	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPKEA	KEA:12756254
MAPK8IP1	MAPK10	P53779	S	15	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPKEA	KEA:12756254
MAPK8IP1	MAPK10	P53779	S	29	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPKEA	KEA:12756254
MAPK8IP1	MAPK10	P53779	S	197	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPKEA	KEA:12756254

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Ligand-Receptor Signaling

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network

15 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
JIP1	Q9UQF2	M4K2	Q12851	Yes	No	Yes	SIGNOR	SIGNOR:10702297
JIP1	Q9UQF2	SUH	Q06330	Yes	No	Yes	SIGNOR	SIGNOR:20508646
MK09	P45984	JIP1	Q9UQF2	Yes	Yes	No	HPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperHINTPhosphoSite_KEAphosphoELM_KEAInnateDBPhosphoNetworksHPRDWangPhosphoSite_ProtMapperBEL-Large-Corpus_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetKEAphosphoELMSIGNOR_ProtMapperREACH_ProtMapperPhosphoSiteSparser_ProtMapper	HPRD:10490659 HINT:10490659 HINT:15998799 KEA:12756254 KEA:15911620 PhosphoSite:12756254 ProtMapper:15212693 InnateDB:15998799 phosphoELM:15911620 SIGNOR:12756254 ProtMapper:12756254 ProtMapper:15998799 PhosphoSite:16195223 ProtMapper:15911620 HINT:33961781
JIP1	Q9UQF2	MK09	P45984	Yes	No	Yes	SIGNORHPRDHINTInnateDBWang	HPRD:10490659 HINT:10490659 HINT:15998799 InnateDB:15998799 SIGNOR:10490659 HINT:33961781
JIP1	Q9UQF2	NOTC1	P46531	Yes	No	Yes	SIGNOR	SIGNOR:20508646

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Protein Complex Composition

8 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
DCDC2-MAPK8IP1 complex	DCDC2 MAPK8IP1	Q9UHG0 Q9UQF2	0:0	CORUM	CORUM:6545	25557784
HT_DM_Cluster521	AP1M1 AP1M2 MAPK8IP1 MAPK8IP2	Q13387 Q9BXS5 Q9UQF2 Q9Y6Q5	1:1:1:1	Compleat	Compleat:HC3345	22036573
JIP1-JIP2 complex	MAPK8IP1 MAPK8IP2	Q13387 Q9UQF2	3:1	CORUMhu.MAP2PDB	PDB:8rppCORUM:6994	28638935
	HOXC8 MAPK8IP1 TTLL4	P31273 Q14679 Q9UQF2	0:0:0	hu.MAP2
	HOXC8 MAPK8IP1	P31273 Q9UQF2	0:0	hu.MAP2
	MAPK8 MAPK8IP1	P45983 Q9UQF2	2:2	PDB	PDB:4e73PDB:3vugPDB:3vuiPDB:3vudPDB:4hysPDB:4hyuPDB:3vuhPDB:2gmxPDB:4izyPDB:2h96PDB:2g01PDB:5lw1PDB:4g1wPDB:3vukPDB:3vulPDB:3vum
	MAPK10 MAPK8IP1	P53779 Q9UQF2	1:1	PDB	PDB:3oxiPDB:4h39PDB:3ptg
	MAPK8IP1	Q9UQF2	4	PDB	PDB:7nyoPDB:7nykPDB:7nymPDB:7nzbPDB:7nynPDB:7nyl

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	9	36064647 38113368 37322475 40189497 40940449 41307968 36146834 27821849 38207106

Sequence, Structure & Domains

Sequences

Length

711

Mass

77,524

Sequence

MAERESGGLGGGAASPPAASPFLGLHIASPPNFRLTHDISLEEFEDEDLSEITDECGISLQCKDTLSLRPPRAGLLSAGGGGAGSRLQAEMLQMDLIDATGDTPGAEDDEEDDDEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGPGSGDTYRPKRPTTLNLFPQVPRSQDTLNNNSLGKKHSWQDRVSRSSSPLKTGEQTPPHEHICLSDELPPQSGPAPTTDRGTSTDSPCRRSTATQMAPPGGPPAAPPGGRGHSHRDRIHYQADVRLEATEEIYLTPVQRPPDAAEPTSAFLPPTESRMSVSSDPDPAAYPSTAGRPHPSISEEEEGFDCLSSPERAEPPGGGWRGSLGEPPPPPRASLSSDTSALSYDSVKYTLVVDEHAQLELVSLRPCFGDYSDESDSATVYDNCASVSSPYESAIGEEYEEAPRPQPPACLSEDSTPDEPDVHFSKKFLNVFMSGRSRSSSAESFGLFSCIINGEEQEQTHRAIFRFVPRHEDELELEVDDPLLVELQAEDYWYEAYNMRTGARGVFPAYYAIEVTKEPEHMAALAKNSDWVDQFRVKFLGSVQVPYHKGNDVLCAAMQKIATTRRLTVHFNPPSSCVLEISVRGVKIGVKADDSQEAKGNKCSHFFQLKNISFCGYHPKNNKYFGFITKHPADHRFACHVFVSEDSTKALAESVGRAFQQFYKQFVEYTCPTEDIYLE

3D Structural Models

Turn

531..533

Helix

541..543

Beta Strand

493..495; 514..520; 524..530; 536..540; 544..546

3D Structure

X-ray crystallography (27)

Domain & Motif Annotations

Compositional Bias

14..25; Low complexity; 105..116; Acidic residues; 139..149; Low complexity; 162..182; Polar residues; 194..204; Polar residues; 228..244; Polar residues; 267..277; Basic and acidic residues

Motif

353..360; D-box 1; 364..372; D-box 2

Domain (CC)

The destruction boxes (D-box) may act as recognition signals for degradation via the ubiquitin-proteasome pathway.; DOMAIN: A minimal inhibitory domain prevents pancreatic beta cell apoptosis in vitro, and prevents activation of c-jun by MAPK8, MAPK9 and MAPK10.; DOMAIN: The SH3 domain mediates homodimerization.

Domain (FT)

488..549; SH3; 561..700; PID

Region

1..27; Disordered; 78..371; Disordered; 127..285; JNK-binding domain (JBD); 157..176; Minimal inhibitory domain (MID); 283..471; Interaction with MAP3K7; 429..451; Disordered; 471..660; Interaction with VRK2

Protein Families

JIP scaffold family

Sequence Similarities

Belongs to the JIP scaffold family.

Clinical Relevance

Disease Involvement

Cancer-related genesDiabetes mellitusDisease variant

Drug Targets

Patented-recorded target

Antibody

HPA058921 HPA070332 HPA079657

Interaction Protein

ENSG00000076984ENSG00000107643ENSG00000135341ENSG00000141736ENSG00000142192

Interaction Count

Interaction Dataset

intact_biogrid