Protein detail

JIP1

C-Jun-amino-terminal kinase-interacting protein 1 (JIP-1) (JNK-interacting protein 1) (Islet-brain 1) (IB-1) (JNK MAP kinase scaffold protein 1) (Mitogen-activated protein kinase 8-interacting protein 1)

Entry name JIP1	UniProt ID Q9UQF2	EVMP score 0.50
Frequency 1	Transmembrane count	Protein classification Cancer-related genesDisease related genesPlasma proteinsPredicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Protein Class

Cancer-related genesDisease related genesPlasma proteinsPredicted intracellular proteins

Protein Function

Cancer-related genes:Mutational cancer driver genes
Disease related genes
Predicted intracellular proteins

Ensembl

ENSG00000121653

Entrez Gene Symbol

MAPK8IP1

Gene Synonym

IB1JIP-1JIP1PRKM8IP

Gene Description

Mitogen-activated protein kinase 8 interacting protein 1

Chromosome

Position

45885651-45906465

Frequency

EVMP Score

0.50

Fluorescence & Localization

Function & Pathway

Protein Function

Cancer-related genes:Mutational cancer driver genes
Disease related genes
Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

KEGG

hsa04010 MAPK signaling pathway

Mediation Categories

Clinical-translation mediationImmune mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

36 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
MAPK8IP1	MAPK10	P53779	T	284	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPKEA	KEA:12756254
MAPK8IP1	MAPK10	P53779	S	341	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPKEA	KEA:12756254
MAPK8IP1	MAPK10	P53779	S	421	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPKEA	KEA:12756254
MAPK8IP1	MAPK10	P53779	T	205	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPKEA	KEA:12756254
MAPK8IP1	MAPK10	P53779	T	103	phosphorylation	KEA	KEA:15911620 KEA:12756254
MAPK8IP1	CSNK1A1	P48729	S	608	phosphorylation	Sparser_ProtMapperProtMapper	ProtMapper:29793495
MAPK8IP1	CDK1	P06493	S	15	phosphorylation	KEA	KEA:17570479
MAPK8IP1	CDK1	P06493	S	341	phosphorylation	KEA	KEA:17570479
MAPK8IP1	CDK2	P24941	S	197	phosphorylation	KEA	KEA:17570479
MAPK8IP1	CDK2	P24941	S	29	phosphorylation	KEA	KEA:17570479

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Ligand-Receptor Signaling

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network

15 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
MK08	P45983	JIP1	Q9UQF2	Yes	Yes	No	SPIKEHPRD_MIMPSIGNORProtMapperdbPTMHINTPhosphoSite_KEAphosphoELM_KEAInnateDBPhosphoNetworksHPRDIntActCancerCellMapWangPhosphoSite_ProtMapperBEL-Large-Corpus_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefPhosphoPointiPTMnetELMKEABioGRIDHPRD_KEAphosphoELMSIGNOR_ProtMapperSPIKE_LCHPRD-phos	HINT:24900545 SIGNOR:12756254 HINT:23020677 HINT:23664880 phosphoELM:12756254 HINT:16759099 dbPTM:12756254 HPRD:9733513 SPIKE:15314024 KEA:15911620 HINT:16854050 ProtMapper:15212693 InnateDB:15998799 HINT:18286207 BioGRID:11700324 HPRD-phos:12756254 ProtMapper:12756254 SPIKE:16840345 ELM:15141161 HINT:16527482 CancerCellMap:11700324 IntAct:16840345 HINT:29126898 HPRD:12756254 HPRD:18286207 HINT:23352510 HINT:33961781 KEA:12756254 HINT:16840345 SPIKE_LC:15314024 SPIKE_LC:16840345
JIP1	Q9UQF2	MK08	P45983	Yes	Yes	Yes	WangSIGNORELMCui2007HINTHPRDBioGRIDCA1IntActInnateDBCancerCellMapSPIKE_LCSignaLink3SPIKE	HINT:24900545 SIGNOR:9922370 SIGNOR:12756254 HINT:23020677 HINT:23664880 HINT:16759099 HPRD:9733513 SPIKE:15314024 HINT:16854050 SIGNOR:18486448 InnateDB:15998799 SPIKE:9933567 HINT:18286207 SIGNOR:10490659 BioGRID:11700324 SPIKE:16840345 ELM:15141161 HINT:16527482 CancerCellMap:11700324 IntAct:16840345 CA1:9235893 SignaLink3:9922370 HINT:29126898 HPRD:12756254 HPRD:18286207 SPIKE_LC:9933567 SignaLink3:23331499 HINT:23352510 HINT:33961781 HINT:16840345 CA1:10490659 SPIKE_LC:15314024 SIGNOR:15141161 SPIKE_LC:16840345
DUS16	Q9BY84	JIP1	Q9UQF2	Yes	Yes	No	InnateDB_SignaLink3SIGNORHPRDSignaLink3InnateDB	SIGNOR:12524447 SignaLink3:12524447 SignaLink3:23180781 SignaLink3:23331499 HPRD:12524447 InnateDB:12524447
JIP1	Q9UQF2	M3K10	Q02779	Yes	Yes	No	SIGNORHPRDCui2007SignaLink3CA1Wang	HPRD:10490659 CA1:9733513 SignaLink3:10490659 SIGNOR:15767678 SignaLink3:23331499 SignaLink3:9868371
JIP1	Q9UQF2	M3K12	Q12852	Yes	Yes	Yes	HPRDSIGNORSignaLink3	HPRD:10490659 SignaLink3:10490659 SignaLink3:23331499 SignaLink3:9868371 SIGNOR:11432832
JIP1	Q9UQF2	MP2K7	O14733	Yes	Yes	No	WangSIGNORHPRDCui2007HINTSignaLink3BioGRIDCA1IntActSPIKE_LC	HPRD:10490659 HINT:10490659 HPRD:16456539 IntAct:16840345 CA1:9733513 SignaLink3:10490659 HINT:16840345 HINT:18286207 SIGNOR:10490659 HPRD:18286207 SignaLink3:23331499 SignaLink3:9868371 BioGRID:16840345 SPIKE_LC:16840345
JIP1	Q9UQF2	M4K1	Q92918	Yes	Yes	No	WangSignaLink3	SignaLink3:9868371 SignaLink3:23331499
SH3R1	Q7Z6J0	JIP1	Q9UQF2	Yes	Yes	No	SIGNORSignaLink3	SignaLink3:16571722 SignaLink3:23331499 SIGNOR:16571722
SHIP2	O15357	JIP1	Q9UQF2	Yes	Yes	No	SignaLink3	SignaLink3:18486448 SignaLink3:23331499
JIP2	Q13387	JIP1	Q9UQF2	Yes	Yes	No	HPRDHINTSIGNOR	HPRD:10490659 HINT:10490659 HPRD:10629060 SIGNOR:10490659 HINT:33961781

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Protein Complex Composition

8 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
DCDC2-MAPK8IP1 complex	DCDC2 MAPK8IP1	Q9UHG0 Q9UQF2	0:0	CORUM	CORUM:6545	25557784
HT_DM_Cluster521	AP1M1 AP1M2 MAPK8IP1 MAPK8IP2	Q13387 Q9BXS5 Q9UQF2 Q9Y6Q5	1:1:1:1	Compleat	Compleat:HC3345	22036573
JIP1-JIP2 complex	MAPK8IP1 MAPK8IP2	Q13387 Q9UQF2	3:1	CORUMhu.MAP2PDB	PDB:8rppCORUM:6994	28638935
	HOXC8 MAPK8IP1 TTLL4	P31273 Q14679 Q9UQF2	0:0:0	hu.MAP2
	HOXC8 MAPK8IP1	P31273 Q9UQF2	0:0	hu.MAP2
	MAPK8 MAPK8IP1	P45983 Q9UQF2	2:2	PDB	PDB:4e73PDB:3vugPDB:3vuiPDB:3vudPDB:4hysPDB:4hyuPDB:3vuhPDB:2gmxPDB:4izyPDB:2h96PDB:2g01PDB:5lw1PDB:4g1wPDB:3vukPDB:3vulPDB:3vum
	MAPK10 MAPK8IP1	P53779 Q9UQF2	1:1	PDB	PDB:3oxiPDB:4h39PDB:3ptg
	MAPK8IP1	Q9UQF2	4	PDB	PDB:7nyoPDB:7nykPDB:7nymPDB:7nzbPDB:7nynPDB:7nyl

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	9	36064647 38113368 37322475 40189497 40940449 41307968 36146834 27821849 38207106

Sequence, Structure & Domains

Sequences

Length

711

Mass

77,524

Sequence

MAERESGGLGGGAASPPAASPFLGLHIASPPNFRLTHDISLEEFEDEDLSEITDECGISLQCKDTLSLRPPRAGLLSAGGGGAGSRLQAEMLQMDLIDATGDTPGAEDDEEDDDEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGPGSGDTYRPKRPTTLNLFPQVPRSQDTLNNNSLGKKHSWQDRVSRSSSPLKTGEQTPPHEHICLSDELPPQSGPAPTTDRGTSTDSPCRRSTATQMAPPGGPPAAPPGGRGHSHRDRIHYQADVRLEATEEIYLTPVQRPPDAAEPTSAFLPPTESRMSVSSDPDPAAYPSTAGRPHPSISEEEEGFDCLSSPERAEPPGGGWRGSLGEPPPPPRASLSSDTSALSYDSVKYTLVVDEHAQLELVSLRPCFGDYSDESDSATVYDNCASVSSPYESAIGEEYEEAPRPQPPACLSEDSTPDEPDVHFSKKFLNVFMSGRSRSSSAESFGLFSCIINGEEQEQTHRAIFRFVPRHEDELELEVDDPLLVELQAEDYWYEAYNMRTGARGVFPAYYAIEVTKEPEHMAALAKNSDWVDQFRVKFLGSVQVPYHKGNDVLCAAMQKIATTRRLTVHFNPPSSCVLEISVRGVKIGVKADDSQEAKGNKCSHFFQLKNISFCGYHPKNNKYFGFITKHPADHRFACHVFVSEDSTKALAESVGRAFQQFYKQFVEYTCPTEDIYLE

3D Structural Models

Turn

531..533

Helix

541..543

Beta Strand

493..495; 514..520; 524..530; 536..540; 544..546

3D Structure

X-ray crystallography (27)

Domain & Motif Annotations

Compositional Bias

14..25; Low complexity; 105..116; Acidic residues; 139..149; Low complexity; 162..182; Polar residues; 194..204; Polar residues; 228..244; Polar residues; 267..277; Basic and acidic residues

Motif

353..360; D-box 1; 364..372; D-box 2

Domain (CC)

The destruction boxes (D-box) may act as recognition signals for degradation via the ubiquitin-proteasome pathway.; DOMAIN: A minimal inhibitory domain prevents pancreatic beta cell apoptosis in vitro, and prevents activation of c-jun by MAPK8, MAPK9 and MAPK10.; DOMAIN: The SH3 domain mediates homodimerization.

Domain (FT)

488..549; SH3; 561..700; PID

Region

1..27; Disordered; 78..371; Disordered; 127..285; JNK-binding domain (JBD); 157..176; Minimal inhibitory domain (MID); 283..471; Interaction with MAP3K7; 429..451; Disordered; 471..660; Interaction with VRK2

Protein Families

JIP scaffold family

Sequence Similarities

Belongs to the JIP scaffold family.

Clinical Relevance

Disease Involvement

Cancer-related genesDiabetes mellitusDisease variant

Drug Targets

Patented-recorded target

Antibody

HPA058921 HPA070332 HPA079657

Interaction Protein

ENSG00000076984ENSG00000107643ENSG00000135341ENSG00000141736ENSG00000142192

Interaction Count

Interaction Dataset

intact_biogrid