Protein detail
KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17)
Protein symbol KCC2A | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Disease related genesEnzymesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17)
Protein Class
Disease related genesEnzymesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Human disease related genes:Other diseases:Mental and behavioural disorders
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Kinases:CAMK Ser/Thr protein kinases
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym
CAMKACaMKIIalphaCaMKIINalphaKIAA0968
Gene Description
Calcium/calmodulin dependent protein kinase II alpha
Chromosome
5
Position
150219491-150290093
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Cell SpecificEarly spermatids
Function & Pathway
Protein Function
- Human disease related genes:Other diseases:Mental and behavioural disorders
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Kinases:CAMK Ser/Thr protein kinases
- Disease related genes
Cellular Component
Molecular Function
- GO:0004674 protein serine/threonine kinase activity
- GO:0004683 calcium/calmodulin-dependent protein kinase activity
- GO:0005515 protein binding
- GO:0005516 calmodulin binding
- GO:0005524 ATP binding
- GO:0016301 kinase activity
- GO:0035254 glutamate receptor binding
- GO:0042802 identical protein binding
- GO:0042803 protein homodimerization activity
- GO:0046872 metal ion binding
- GO:0106310 protein serine kinase activity
KEGG
- hsa04012 ErbB signaling pathway
- KEGG:hsa04020 Calcium signaling pathway
- KEGG:hsa04024 cAMP signaling pathway
- KEGG:hsa04066 HIF-1 signaling pathway
- KEGG:hsa04114 Oocyte meiosis
- KEGG:hsa04148 Efferocytosis
- KEGG:hsa04217 Necroptosis
- KEGG:hsa04261 Adrenergic signaling in cardiomyocytes
- KEGG:hsa04310 Wnt signaling pathway
- KEGG:hsa04360 Axon guidance
- KEGG:hsa04713 Circadian entrainment
- KEGG:hsa04720 Long-term potentiation
- KEGG:hsa04722 Neurotrophin signaling pathway
- KEGG:hsa04725 Cholinergic synapse
- KEGG:hsa04728 Dopaminergic synapse
- KEGG:hsa04740 Olfactory transduction
- KEGG:hsa04750 Inflammatory mediator regulation of TRP channels
- KEGG:hsa04911 Insulin secretion
- KEGG:hsa04912 GnRH signaling pathway
- KEGG:hsa04916 Melanogenesis
- KEGG:hsa04921 Oxytocin signaling pathway
- KEGG:hsa04922 Glucagon signaling pathway
- KEGG:hsa04925 Aldosterone synthesis and secretion
- KEGG:hsa04934 Cushing syndrome
- KEGG:hsa04971 Gastric acid secretion
- KEGG:hsa05012 Parkinson disease
- KEGG:hsa05022 Pathways of neurodegeneration - multiple diseases
- KEGG:hsa05031 Amphetamine addiction
- KEGG:hsa05152 Tuberculosis
- KEGG:hsa05200 Pathways in cancer
- KEGG:hsa05205 Proteoglycans in cancer
- KEGG:hsa05214 Glioma
- KEGG:hsa05415 Diabetic cardiomyopathy
- KEGG:hsa05417 Lipid and atherosclerosis
Reactome
- R-hsa-442755 activation of nmda receptors and postsynaptic events
- R-hsa-9609736 assembly and cell surface presentation of nmda receptors
- R-hsa-3858494 beta catenin independent wnt signaling
- R-hsa-4086398 ca2 pathway
- R-hsa-111932 camk iv mediated phosphorylation of creb
- R-hsa-5576891 cardiac conduction
- R-hsa-111996 ca dependent events
- R-hsa-8953897 cellular responses to stimuli
- R-hsa-3371556 cellular response to heat stress
- R-hsa-442742 creb1 phosphorylation through nmda receptor mediated activation of ras signaling
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-1489509 dag and ip3 signaling
- R-hsa-9918481 dengue virus host interactions
- R-hsa-9839923 dengue virus infection
- R-hsa-5663202 diseases of signal transduction by growth factor receptors and second messengers
- R-hsa-418594 g alpha i signalling events
- R-hsa-112040 g protein mediated events
- R-hsa-3371571 hsf1 dependent transactivation
- R-hsa-5663205 infectious disease
- R-hsa-877300 interferon gamma signaling
- R-hsa-913531 interferon signaling
- R-hsa-9006925 intracellular signaling by second messengers
- R-hsa-983712 ion channel transport
- R-hsa-5578775 ion homeostasis
- R-hsa-936837 ion transport by p type atpases
- R-hsa-9620244 long term potentiation
- R-hsa-5684996 mapk1 mapk3 signaling
- R-hsa-5683057 mapk family signaling cascades
- R-hsa-397014 muscle contraction
- R-hsa-9617324 negative regulation of nmda receptor mediated neuronal transmission
- R-hsa-112316 neuronal system
- R-hsa-112314 neurotransmitter receptors and postsynaptic signal transmission
- R-hsa-6802957 oncogenic mapk signaling
- R-hsa-111885 opioid signalling
- R-hsa-5576892 phase 0 rapid depolarisation
- R-hsa-5673000 raf activation
- R-hsa-442982 ras activation upon ca2 influx through nmda receptor
- R-hsa-9022692 regulation of mecp2 expression and activity
- R-hsa-73857 rna polymerase ii transcription
- R-hsa-6802952 signaling by braf and raf1 fusions
- R-hsa-372790 signaling by gpcr
- R-hsa-6802946 signaling by moderate kinase activity braf mutants
- R-hsa-195721 signaling by wnt
- R-hsa-399719 trafficking of ampa receptors
- R-hsa-8986944 transcriptional regulation by mecp2
- R-hsa-112315 transmission across chemical synapses
- R-hsa-382551 transport of small molecules
- R-hsa-438066 unblocking of nmda receptors glutamate binding and activation
- R-hsa-9824446 viral infection pathways
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
10 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| CAMK2A | PPM1F | P49593 | T | 286 | dephosphorylation | SIGNOR | SIGNOR:15140879 |
| CAMK2A | PPM1F | P49593 | T | 286 | phosphorylation | SIGNOR_ProtMapperProtMapper | ProtMapper:15140879 |
| CAMK2A | CAMK4 | Q16566 | S | 332 | phosphorylation | MIMPPhosphoSitePhosphoSite_MIMP | |
| CAMK2A | CAMK1 | Q14012 | S | 332 | phosphorylation | MIMPPhosphoSitePhosphoSite_MIMP | |
| CAMK2A | GRK5 | P34947 | S | 333 | phosphorylation | PhosphoNetworks | |
| CAMK2A | GRK5 | P34947 | T | 336 | phosphorylation | PhosphoNetworks | |
| CAMK2A | PLCG1 | P19174 | T | 286 | phosphorylation | NCI-PID_ProtMapperProtMapper | ProtMapper:12367511 |
| CAMK2A | CSNK1E | P49674 | S | 333 | phosphorylation | KEA | KEA:17570479 |
| CAMK2A | PRKCA | P17252 | T | 286 | phosphorylation | KEA | KEA:10087064 |
| CAMK2A | PRKCB | P05771 | T | 286 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling
13 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
| transmembrane_phobius | transmembrane_predicted | Almen2009 | No | No | No | No | No |
| transmembrane_sosui | transmembrane_predicted | Almen2009 | No | No | No | No | No |
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Regulatory Interaction Network
82 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KCC2A | Q9UQM7 | ZN363 | Q96PM5 | Yes | No | Yes | WangPhosphoSite_MIMPMIMPPhosphoSite_norefSIGNORiPTMnetProtMapperCui2007SIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapperSPIKE_LC | ProtMapper:17568776SIGNOR:17568776PhosphoSite:17568776SPIKE_LC:17568776 |
| KCC2A | Q9UQM7 | CALD1 | Q05682 | Yes | No | Yes | SIGNOR_ProtMapperiPTMnetSIGNORProtMapper | ProtMapper:2170388SIGNOR:2170388 |
| KCC2A | Q9UQM7 | PTTG1 | O95997 | Yes | No | Yes | PhosphoSite_norefSIGNORProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:24781523PhosphoSite:24781523 |
| KCC2A | Q9UQM7 | CYLD | Q9NQC7 | Yes | Yes | No | PhosphoSite_norefSIGNORiPTMnetProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:24614225SIGNOR:24614225PhosphoSite:24614225 |
| KCC2A | Q9UQM7 | SRF | P11831 | Yes | Yes | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDHINTPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperPhosphoSiteHPRD-phosPhosphoSite_ProtMapper | HPRD-phos:8413226PhosphoSite:12684542HPRD-phos:10318869KEA:10318869HINT:8413226ProtMapper:10318869HPRD:10753652ProtMapper:10753652PhosphoSite:11859076HPRD:10318869KEA:12171911KEA:10753652HINT:10318869iPTMnet:8413226HINT:10753652HPRD:8413226SIGNOR:10753652PhosphoSite:10318869ProtMapper:8413226KEA:8413226PhosphoSite:8413226HPRD-phos:10753652 |
| KCC2A | Q9UQM7 | CEBPB | P17676 | Yes | Yes | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperHPRD-phos | KEA:1314426SIGNOR:1314426ProtMapper:1314426HPRD:1314426HPRD-phos:1314426 |
| KCC2A | Q9UQM7 | TY3H | P07101 | Yes | Yes | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_ProtMapperHPRD_MIMPPhosphoSite_norefPhosphoPointSIGNORProtMapperiPTMnetPhosphoSite_KEAKEAphosphoELM_KEAphosphoELMSIGNOR_ProtMapperPhosphoSiteNetworKIN_KEA | PhosphoSite:34031189KEA:17570479ProtMapper:1680128PhosphoSite:24055376KEA:12421349KEA:1680128KEA:11359875phosphoELM:1680128KEA:6150037PhosphoSite:34238765KEA:1347949PhosphoSite:16626642SIGNOR:1680128KEA:11502746KEA:7901013 |
| KCC2A | Q9UQM7 | HSF1 | Q00613 | Yes | Yes | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAphosphoELM_KEAHPRD_KEAphosphoELMSIGNOR_ProtMapperPhosphoSiteHPRD-phosPhosphoSite_ProtMapper | KEA:15302935PhosphoSite:24746225ProtMapper:11447121PhosphoSite:26193369PhosphoSite:15760475PhosphoSite:25963659phosphoELM:11447121HPRD:11447121PhosphoSite:23587601HPRD-phos:11447121PhosphoSite:25380824PhosphoSite:26361762SIGNOR:11447121PhosphoSite:22496356PhosphoSite:28415561PhosphoSite:11447121KEA:11447121PhosphoSite:33177089 |
| KCC2A | Q9UQM7 | CLCN3 | P51790 | Yes | Yes | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointSIGNORProtMapperPhosphoSite_KEAKEAphosphoELM_KEAphosphoELMPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:14754994PhosphoSite:23165767KEA:14754994phosphoELM:14754994SIGNOR:14754994 |
| KCC2A | Q9UQM7 | ANS1B | Q7Z6G8 | Yes | No | Yes | SIGNOR | SIGNOR:27477489 |
Protein Complex Composition
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| Ternary complex (LRRC7CAMK2aACTN4) | ACTN4CAMK2A | O43707Q9UQM7 | 1:1 | Compleat | Compleat:HC896 | 11160423 |
| CAMK2ACLK3HSF1HSF2KRT18SUMO2SUMO3 | P05783P49761P55854P61956Q00613Q03933Q9UQM7 | 1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC6562 | ||
| CAMK2AGRIA1 | P42261Q9UQM7 | 1:1 | PDB | PDB:6x5q | ||
| CAMK2A | Q9UQM7 | 2 | PDB | PDB:6of8PDB:7recPDB:6w4pPDB:2vz6PDB:9eoyPDB:5ig3PDB:6w4o |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 26801919 |
Sequence, Structure & Domains
Sequences
Length
478
Mass
54,088
Sequence
MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSGGKSGGNKKSDGVKESSESTNTTIEDEDTKVRKQEIIKVTEQLIEAISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIHLMGDESACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPSVLPH
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=A; IsoId=Q9UQM7-1; Sequence=Displayed; Name=B; IsoId=Q9UQM7-2; Sequence=VSP_004766
Alternative Sequence
328; K -> KKRKSSSSVQLM (in isoform B)
3D Structural Models
Turn
256..258; 402..406; 423..425
Helix
8..12; 33..35; 46..48; 51..66; 97..104; 109..128; 138..140; 157..159; 177..179; 182..186; 193..208; 218..227; 236..239; 242..251; 262..266; 269..272; 274..277; 284..298; 347..362; 366..372; 382..384; 393..401
Beta Strand
13..21; 26..32; 37..45; 75..81; 84..89; 141..144; 152..154; 373..380; 388..392; 410..422; 426..438; 440..442; 444..458; 461..471
3D Structure
Electron microscopy (2); X-ray crystallography (20)
Domain & Motif Annotations
Compositional Bias
322..331; Basic and acidic residues
Domain (FT)
13..271; Protein kinase
Region
290..300; Calmodulin-binding; 310..320; Interaction with BAALC; 314..341; Disordered
Protein Families
- Protein kinase superfamily
- CAMK Ser/Thr protein kinase family
- CaMK subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Clinical Relevance
Disease Involvement
Disease variantIntellectual disability
Interaction Protein
ENSG00000055208ENSG00000058404ENSG00000080824ENSG00000105401ENSG00000145349ENSG00000163788ENSG00000273079
Interaction Count
7
Interaction Dataset
intact_biogridbiogrid_bioplex