Protein detail

TRPC6

Short transient receptor potential channel 6 (TrpC6) (Transient receptor protein 6) (TRP-6)

Entry name TRPC6	UniProt ID Q9Y210	EVMP score 0.38
Frequency 7	Transmembrane count 6	Protein classification Disease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted membrane proteinsTransportersVoltage-gated ion channels

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Short transient receptor potential channel 6 (TrpC6) (Transient receptor protein 6) (TRP-6)

Protein Class

Disease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted membrane proteinsTransportersVoltage-gated ion channels

Protein Function

Voltage-gated ion channels:Transient Receptor Potential Channels
Human disease related genes:Urinary system diseases:Kidney diseases
Potential drug targets
Transporters:Transporter channels and pores
Disease related genes

Transmembrane

439..459; Helical; 488..508; Helical; 522..542; Helical; 593..613; Helical; 637..657; Helical; 707..727; Helical

Transmembrane Count

Ensembl

ENSG00000137672

Entrez Gene Symbol

TRPC6

Gene Synonym

FSGS2TRP6

Gene Description

Transient receptor potential cation channel subfamily C member 6

Chromosome

Position

101451564-101872562

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue SpecificbrainCell SpecificBrain excitatory neuronsSingle-Nuclei Brain Specificthalamic excitatoryBlood Cell Specificnaive CD4 T-cellBlood Lineage SpecificT-cells

Function & Pathway

Protein Function

Voltage-gated ion channels:Transient Receptor Potential Channels
Human disease related genes:Urinary system diseases:Kidney diseases
Potential drug targets
Transporters:Transporter channels and pores
Disease related genes

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Fusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

5 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
TRPC6	PRKACA	P17612	T	70	phosphorylation	PhosphoSite
TRPC6	PRKG1	Q13976	T	70	phosphorylation	Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:21402151
TRPC6	PRKG1	Q13976	S	322	phosphorylation	PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper
TRPC6	CDK5	Q00535	S	14	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper
TRPC6	SRC	P12931	Y	31	phosphorylation	REACH_ProtMapperSparser_ProtMapperProtMapper	ProtMapper:21471003

Ligand-Receptor Signaling

22 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transporter	transporter	OmniPath	No	Yes	No	No	No
ion_channel	ion_channel	OmniPath	No	Yes	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	TopDB	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

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Regulatory Interaction Network

5 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
FYN	P06241	TRPC6	Q9Y210	Yes	Yes	No	TRIPPhosphoPointSIGNORHPRDSPIKE_LC	TRIP:14761972 HPRD:14761972 SIGNOR:21471003 SPIKE_LC:16713569
KAPCA	P17612	TRPC6	Q9Y210	Yes	No	No	TRIPPhosphoSitePhosphoSite_ProtMapperProtMapper	PhosphoSite:23645677 TRIP:22001259 PhosphoSite:19961855 TRIP:23645677
KGP1	Q13976	TRPC6	Q9Y210	Yes	No	Yes	Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefSIGNORTRIPProtMapperiPTMnetREACH_ProtMapperPhosphoSite_ProtMapper	TRIP:18617565 SIGNOR:19961855 ProtMapper:21402151 TRIP:24740790
SRC	P12931	TRPC6	Q9Y210	Yes	Yes	No	TRIPPhosphoPointSIGNORProtMapperHPRDREACH_ProtMapper	TRIP:14761972 HPRD:14761972 SIGNOR:21471003 ProtMapper:21471003
CDK5	Q00535	TRPC6	Q9Y210	Yes	No	No	PhosphoSitePhosphoSite_ProtMapperProtMapper	PhosphoSite:28877958

Protein Complex Composition

6 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
MX1 STMN1 TRPC1 TRPC3 TRPC4 TRPC5 TRPC6 UBC UHMK1	P0CG48 P16949 P20591 P48995 Q13507 Q8TAS1 Q9UBN4 Q9UL62 Q9Y210	1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4503
HOMER3 MX1 PLCB2 TRPC1 TRPC3 TRPC4 TRPC5 TRPC6 UBC	P0CG48 P20591 P48995 Q00722 Q13507 Q9NSC5 Q9UBN4 Q9UL62 Q9Y210	1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9804
CYSTM1 HOMER3 MX1 TRPC1 TRPC3 TRPC4 TRPC5 TRPC6 UBC ZFP36L1	P0CG48 P20591 P48995 Q07352 Q13507 Q9H1C7 Q9NSC5 Q9UBN4 Q9UL62 Q9Y210	1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8189
DYNLL2 HOMER3 MX1 TRPC1 TRPC3 TRPC4 TRPC5 TRPC6 UBC	P0CG48 P20591 P48995 Q13507 Q96FJ2 Q9NSC5 Q9UBN4 Q9UL62 Q9Y210	1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6430
HOMER3 ITCH MX1 TRPC1 TRPC3 TRPC4 TRPC5 TRPC6	P20591 P48995 Q13507 Q96J02 Q9NSC5 Q9UBN4 Q9UL62 Q9Y210	1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8943
TRPC6	Q9Y210	4	PDB	PDB:7a6uPDB:6uzaPDB:6uz8PDB:7dxgPDB:7dxfPDB:5yx9

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Western blottingELISA	4	30805606 38731868 26775013 40098346

Sequence, Structure & Domains

Sequences

Length

931

Mass

106,326

Sequence

MSQSPAFGPRRGSSPRGAAGAAARRNESQDYLLMDSELGEDGCPQAPLPCYGYYPCFRGSDNRLAHRRQTVLREKGRRLANRGPAYMFSDRSTSLSIEEERFLDAAEYGNIPVVRKMLEECHSLNVNCVDYMGQNALQLAVANEHLEITELLLKKENLSRVGDALLLAISKGYVRIVEAILSHPAFAEGKRLATSPSQSELQQDDFYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCKCNDCNQKQKHDSFSHSRSRINAYKGLASPAYLSLSSEDPVMTALELSNELAVLANIEKEFKNDYKKLSMQCKDFVVGLLDLCRNTEEVEAILNGDVETLQSGDHGRPNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAVKFLVVLAVAIGLPFLALIYWFAPCSKMGKIMRGPFMKFVAHAASFTIFLGLLVMNAADRFEGTKLLPNETSTDNAKQLFRMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIKWDPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLFYLLLKLKKWISELFQGHKKGFQEDAEMNKINEEKKLGILGSHEDLSKLSLDKKQVGHNKQPSIRSSEDFHLNSFNNPPRQYQKIMKRLIKRYVLQAQIDKESDEVNEGELKEIKQDISSLRYELLEEKSQNTEDLAELIRELGEKLSMEPNQEETNR

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9Y210-1; Sequence=Displayed; Name=2; IsoId=Q9Y210-2; Sequence=VSP_006572; Name=3; IsoId=Q9Y210-3; Sequence=VSP_006573

Alternative Sequence

316..431; Missing (in isoform 2); 377..431; Missing (in isoform 3)

3D Structural Models

Turn

350..352; 397..399; 431..437; 521..523; 618..620; 634..636; 681..684; 762..766

Helix

97..108; 111..119; 136..142; 146..152; 161..171; 174..180; 184..186; 222..228; 232..240; 258..264; 268..280; 283..289; 293..310; 315..334; 339..346; 364..371; 375..378; 381..392; 405..415; 417..426; 439..459; 460..464; 484..487; 493..520; 526..557; 578..580; 583..585; 591..605; 606..612; 614..616; 621..630; 631..633; 637..656; 671..680; 688..691; 698..731; 737..751; 854..875; 881..917

Beta Strand

122..124; 131..133; 155..157; 187..190; 205..212; 214..216; 312..314; 357..360; 428..430; 478..482; 660..666; 668..670; 693..696; 754..757

3D Structure

Electron microscopy (6)

Domain & Motif Annotations

Compositional Bias

1..23; Low complexity

Repeat

97..126; ANK 1; 132..161; ANK 2; 163..189; ANK 3; 218..247; ANK 4

Region

1..26; Disordered

Protein Families

Transient receptor (TC 1.A.4) family
STrpC subfamily
TRPC6 sub-subfamily

Sequence Similarities

Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC6 sub-subfamily.

Clinical Relevance

Disease Involvement

Disease variant

Antibody

HPA045098