Protein detail

TRPC6

Short transient receptor potential channel 6 (TrpC6) (Transient receptor protein 6) (TRP-6)

Entry name TRPC6	UniProt ID Q9Y210	EVMP confidence score 0.38
Supporting publications (n) 7	Transmembrane count 6	Protein classification Disease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted membrane proteinsTransportersVoltage-gated ion channels

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Short transient receptor potential channel 6 (TrpC6) (Transient receptor protein 6) (TRP-6)

Protein Class (7)

Disease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted membrane proteinsTransportersVoltage-gated ion channels

Protein Function (5)

Voltage-gated ion channels:Transient Receptor Potential Channels
Human disease related genes:Urinary system diseases:Kidney diseases
Potential drug targets
Transporters:Transporter channels and pores
Disease related genes

Transmembrane

439..459; Helical; 488..508; Helical; 522..542; Helical; 593..613; Helical; 637..657; Helical; 707..727; Helical

Transmembrane Count

Ensembl

ENSG00000137672

Entrez Gene Symbol

TRPC6

Gene Synonym (2)

FSGS2TRP6

Gene Description

Transient receptor potential cation channel subfamily C member 6

Chromosome

Position

101451564-101872562

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization5

Tissue SpecificbrainCell SpecificBrain excitatory neuronsSingle-Nuclei Brain Specificthalamic excitatoryBlood Cell Specificnaive CD4 T-cellBlood Lineage SpecificT-cells

Function & Pathway7

Protein Function (5)

Voltage-gated ion channels:Transient Receptor Potential Channels
Human disease related genes:Urinary system diseases:Kidney diseases
Potential drug targets
Transporters:Transporter channels and pores
Disease related genes

Cellular Component (5)

Molecular Function (6)

Biological Process (3)

KEGG (3)

Reactome (15)

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Mediation Categories (4)

Fusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence39

Enzyme-Mediated Modification (5)

5 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
TRPC6	PRKACA	P17612	T	70	phosphorylation	PhosphoSite
TRPC6	PRKG1	Q13976	T	70	phosphorylation	Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:21402151
TRPC6	PRKG1	Q13976	S	322	phosphorylation	PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper
TRPC6	CDK5	Q00535	S	14	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper
TRPC6	SRC	P12931	Y	31	phosphorylation	REACH_ProtMapperSparser_ProtMapperProtMapper	ProtMapper:21471003

Ligand-Receptor Signaling (22)

22 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transporter	transporter	OmniPath	No	Yes	No	No	No
ion_channel	ion_channel	OmniPath	No	Yes	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	TopDB	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

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Regulatory Interaction Network (5)

5 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
FYN	P06241	TRPC6	Q9Y210	Yes	Yes	No	TRIPPhosphoPointSIGNORHPRDSPIKE_LC	TRIP:14761972 HPRD:14761972 SIGNOR:21471003 SPIKE_LC:16713569
KAPCA	P17612	TRPC6	Q9Y210	Yes	No	No	TRIPPhosphoSitePhosphoSite_ProtMapperProtMapper	PhosphoSite:23645677 TRIP:22001259 PhosphoSite:19961855 TRIP:23645677
KGP1	Q13976	TRPC6	Q9Y210	Yes	No	Yes	Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefSIGNORTRIPProtMapperiPTMnetREACH_ProtMapperPhosphoSite_ProtMapper	TRIP:18617565 SIGNOR:19961855 ProtMapper:21402151 TRIP:24740790
SRC	P12931	TRPC6	Q9Y210	Yes	Yes	No	TRIPPhosphoPointSIGNORProtMapperHPRDREACH_ProtMapper	TRIP:14761972 HPRD:14761972 SIGNOR:21471003 ProtMapper:21471003
CDK5	Q00535	TRPC6	Q9Y210	Yes	No	No	PhosphoSitePhosphoSite_ProtMapperProtMapper	PhosphoSite:28877958

Protein Complex Composition (6)

6 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
MX1 STMN1 TRPC1 TRPC3 TRPC4 TRPC5 TRPC6 UBC UHMK1	P0CG48 P16949 P20591 P48995 Q13507 Q8TAS1 Q9UBN4 Q9UL62 Q9Y210	1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4503
HOMER3 MX1 PLCB2 TRPC1 TRPC3 TRPC4 TRPC5 TRPC6 UBC	P0CG48 P20591 P48995 Q00722 Q13507 Q9NSC5 Q9UBN4 Q9UL62 Q9Y210	1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9804
CYSTM1 HOMER3 MX1 TRPC1 TRPC3 TRPC4 TRPC5 TRPC6 UBC ZFP36L1	P0CG48 P20591 P48995 Q07352 Q13507 Q9H1C7 Q9NSC5 Q9UBN4 Q9UL62 Q9Y210	1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8189
DYNLL2 HOMER3 MX1 TRPC1 TRPC3 TRPC4 TRPC5 TRPC6 UBC	P0CG48 P20591 P48995 Q13507 Q96FJ2 Q9NSC5 Q9UBN4 Q9UL62 Q9Y210	1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6430
HOMER3 ITCH MX1 TRPC1 TRPC3 TRPC4 TRPC5 TRPC6	P20591 P48995 Q13507 Q96J02 Q9NSC5 Q9UBN4 Q9UL62 Q9Y210	1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8943
TRPC6	Q9Y210	4	PDB	PDB:7a6uPDB:6uzaPDB:6uz8PDB:7dxgPDB:7dxfPDB:5yx9

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Western blottingELISA	4	30805606 38731868 26775013 40098346

Sequence, Structure & Domains14

Sequences

Length

931

Mass

106,326

Sequence

MSQSPAFGPRRGSSPRGAAGAAARRNESQDYLLMDSELGEDGCPQAPLPCYGYYPCFRGSDNRLAHRRQTVLREKGRRLANRGPAYMFSDRSTSLSIEEERFLDAAEYGNIPVVRKMLEECHSLNVNCVDYMGQNALQLAVANEHLEITELLLKKENLSRVGDALLLAISKGYVRIVEAILSHPAFAEGKRLATSPSQSELQQDDFYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCKCNDCNQKQKHDSFSHSRSRINAYKGLASPAYLSLSSEDPVMTALELSNELAVLANIEKEFKNDYKKLSMQCKDFVVGLLDLCRNTEEVEAILNGDVETLQSGDHGRPNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAVKFLVVLAVAIGLPFLALIYWFAPCSKMGKIMRGPFMKFVAHAASFTIFLGLLVMNAADRFEGTKLLPNETSTDNAKQLFRMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIKWDPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLFYLLLKLKKWISELFQGHKKGFQEDAEMNKINEEKKLGILGSHEDLSKLSLDKKQVGHNKQPSIRSSEDFHLNSFNNPPRQYQKIMKRLIKRYVLQAQIDKESDEVNEGELKEIKQDISSLRYELLEEKSQNTEDLAELIRELGEKLSMEPNQEETNR

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9Y210-1; Sequence=Displayed; Name=2; IsoId=Q9Y210-2; Sequence=VSP_006572; Name=3; IsoId=Q9Y210-3; Sequence=VSP_006573

Alternative Sequence

316..431; Missing (in isoform 2); 377..431; Missing (in isoform 3)

3D Structural Models

Turn

350..352; 397..399; 431..437; 521..523; 618..620; 634..636; 681..684; 762..766

Helix

97..108; 111..119; 136..142; 146..152; 161..171; 174..180; 184..186; 222..228; 232..240; 258..264; 268..280; 283..289; 293..310; 315..334; 339..346; 364..371; 375..378; 381..392; 405..415; 417..426; 439..459; 460..464; 484..487; 493..520; 526..557; 578..580; 583..585; 591..605; 606..612; 614..616; 621..630; 631..633; 637..656; 671..680; 688..691; 698..731; 737..751; 854..875; 881..917

Beta Strand

122..124; 131..133; 155..157; 187..190; 205..212; 214..216; 312..314; 357..360; 428..430; 478..482; 660..666; 668..670; 693..696; 754..757

3D Structure

Electron microscopy (6)

Domain & Motif Annotations

Compositional Bias

1..23; Low complexity

Repeat

97..126; ANK 1; 132..161; ANK 2; 163..189; ANK 3; 218..247; ANK 4

Region

1..26; Disordered

Protein Families (3)

Transient receptor (TC 1.A.4) family
STrpC subfamily
TRPC6 sub-subfamily

Sequence Similarities

Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC6 sub-subfamily.

Clinical Relevance2

Disease Involvement

Disease variant

Antibody

HPA045098

Supporting Publications7

PMID	Title	Abstract
29148239	Metabolic Signature of Microvesicles from Umbilical Cord Mesenchymal Stem Cells of Preterm and Term Infants.	No abstract available
36398564	Differential ultracentrifugation enables deep plasma proteomics through enrichment of extracellular vesicles.	No abstract available
36797805	Magnetic transferrin nanoparticles (MTNs) assay as a novel isolation approach for exosomal biomarkers in neurological diseases.	No abstract available
37205098	Proteomic profiling of extracellular vesicles in synovial fluid and plasma from Oligoarticular Juvenile Idiopathic Arthritis patients reveals novel immunopathogenic biomarkers.	No abstract available
39558134	Serum small extracellular vesicles-derived BST2 as a biomarker for papillary thyroid microcarcinoma promotes lymph node metastasis.	No abstract available
39569406	Proteomics of circulating extracellular vesicles reveals diverse clinical presentations of COVID-19 but fails to identify viral peptides.	No abstract available
39766158	A Proteomic Examination of Plasma Extracellular Vesicles Across Colorectal Cancer Stages Uncovers Biological Insights That Potentially Improve Prognosis.	No abstract available