Protein detail
S22AD
Solute carrier family 22 member 13 (Organic anion transporter 10) (OAT10) (Organic cation transporter-like 3) (ORCTL-3) (ORCTL3)
Entry name S22AD | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) | Transmembrane count 12 | Protein classification Metabolic proteinsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information12
Protein Names
Solute carrier family 22 member 13 (Organic anion transporter 10) (OAT10) (Organic cation transporter-like 3) (ORCTL-3) (ORCTL3)
Protein Class (3)
Metabolic proteinsPredicted membrane proteinsTransporters
Protein Function
Transporters:Electrochemical Potential-driven transporters
Transmembrane
21..41; Helical; 139..159; Helical; 168..188; Helical; 196..216; Helical; 225..245; Helical; 252..272; Helical; 333..353; Helical; 355..375; Helical; 398..418; Helical; 428..448; Helical; 453..473; Helical; 479..499; Helical
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
OAT10OCTL1OCTL3ORCTL3
Gene Description
Solute carrier family 22 member 13
Chromosome
3
Position
38265812-38278757
EVMP confidence score
0.38
Fluorescence & Localization7
Tissue SpecificintestineCell SpecificEnterocytesSingle-Nuclei Brain Specificendothelial cellBlood Cell SpecificgdT-cellBlood Lineage SpecificmonocytesSecretome LocationIntracellular and membraneSecretome FunctionEnzyme
Function & Pathway7
Protein Function
Transporters:Electrochemical Potential-driven transporters
Cellular Component (5)
Molecular Function (2)
Biological Process (3)
Reactome (3)
Canonical Pathways
M108 Pid netrin pathway
Mediation Categories (3)
Fusion and delivery mediationImmune mediationMetabolism mediation
Relations & Evidence23
Ligand-Receptor Signaling (22)
22 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transporter | transporter | Surfaceome | No | Yes | No | No | No |
| solute_carrier | transporter | Almen2009 | No | Yes | No | No | No |
| mfs | transporter | Surfaceome | No | Yes | No | No | No |
| slc22 | transporter | Surfaceome | No | Yes | No | No | No |
| slc | transporter | Surfaceome | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
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Sequence, Structure & Domains9
Sequences
Length
551
Mass
60,862
Sequence
MAQFVQVLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVLDEPHHCAVAWVKNHTFNLSAAEQLVLSVPLDTAGHPEPCLMFRPPPANASLQDILSHRFNETQPCDMGWEYPENRLPSLKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFTLIGLATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFSLGQMVLAGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKAASVNRRKLSPELMNQLVPEKTGPSGNALDLFRHPQLRKVTLIIFCVWFVDSLGYYGLSLQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCIIIIFIPADLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGILTPLVILLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDLELGPHPRSPKSVPSEKETEAKGRTSSPGVAFVSSTYF
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y226-1; Sequence=Displayed; Name=2; IsoId=Q9Y226-2; Sequence=VSP_017830
Alternative Sequence
451..551; TGMGLVGIFSRIGGILTPLVILLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDLELGPHPRSPKSVPSEKETEAKGRTSSPGVAFVSSTYF -> AWGWWASSHGSGASSHHL (in isoform 2)
Domain & Motif Annotations
Compositional Bias
527..536; Basic and acidic residues; 537..551; Polar residues
Region
511..551; Disordered
Protein Families (2)
- Major facilitator (TC 2.A.1) superfamily
- Organic cation transporter (TC 2.A.1.19) family
Sequence Similarities
Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.