Protein detail

LZTS1

Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer-related gene-coding leucine-zipper motif) (Fez1)

Entry name LZTS1	UniProt ID Q9Y250	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count	Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer-related gene-coding leucine-zipper motif) (Fez1)

Protein Class (4)

Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins

Protein Function (3)

Disease related genes
Human disease related genes:Cancers:Cancers of the digestive system
Predicted intracellular proteins

Ensembl

ENSG00000061337

Entrez Gene Symbol

LZTS1

Gene Synonym

FEZ1

Gene Description

Leucine zipper tumor suppressor 1

Chromosome

Position

20246165-20303963

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization1

Function & Pathway6

Protein Function (3)

Disease related genes
Human disease related genes:Cancers:Cancers of the digestive system
Predicted intracellular proteins

Cellular Component (5)

Molecular Function

GO:0005515 protein binding

Biological Process (3)

Canonical Pathways

M108 Pid netrin pathway

Mediation Categories

Receptor-signaling mediation

Relations & Evidence8

Ligand-Receptor Signaling (6)

6 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	ASB7 ELOB ELOC LZTS1	Q15369 Q15370 Q9H672 Q9Y250	1:1:1:1	PDB	PDB:8y1u

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Western blotting	1	40098346

Sequence, Structure & Domains12

Sequences

Length

596

Mass

66,613

Sequence

MGSVSSLISGHSFHSKHCRASQYKLRKSSHLKKLNRYSDGLLRFGFSQDSGHGKSSSKMGKSEDFFYIKVSQKARGSHHPDYTALSSGDLGGQAGVDFDPSTPPKLMPFSNQLEMGSEKGAVRPTAFKPVLPRSGAILHSSPESASHQLHPAPPDKPKEQELKPGLCSGALSDSGRNSMSSLPTHSTSSSYQLDPLVTPVGPTSRFGGSAHNITQGIVLQDSNMMSLKALSFSDGGSKLGHSNKADKGPSCVRSPISTDECSIQELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSYVAMYQRNQRLEKALQQLARGDSAGEPLEVDLEGADIPYEDIIATEI

Alternative Products

Event=Alternative splicing; Named isoforms=7; Name=1; IsoId=Q9Y250-1; Sequence=Displayed; Name=2; IsoId=Q9Y250-2; Sequence=VSP_009946; Name=3; IsoId=Q9Y250-3; Sequence=VSP_009945; Name=4; IsoId=Q9Y250-4; Sequence=VSP_009944; Name=5; IsoId=Q9Y250-5; Sequence=VSP_009943; Name=6; IsoId=Q9Y250-6; Sequence=VSP_009942; Name=7; IsoId=Q9Y250-7; Sequence=VSP_009940, VSP_009941

Alternative Sequence

55..76; SSSKMGKSEDFFYIKVSQKARG -> AMTRCPRASSMSGSCGRRRRRR (in isoform 7); 77..596; Missing (in isoform 7); 186..571; Missing (in isoform 6); 454..545; Missing (in isoform 5); 468..526; Missing (in isoform 4); 471..503; Missing (in isoform 3); 505..527; Missing (in isoform 2)

3D Structural Models

Helix

347..363; 364..367

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

153..162; Basic and acidic residues; 178..190; Low complexity; 295..310; Basic and acidic residues

Coiled Coil

256..374

Region

136..193; Disordered; 295..324; Disordered

Protein Families

LZTS family

Sequence Similarities

Belongs to the LZTS family.

Clinical Relevance5

Disease Involvement

Tumor suppressor

Antibody (2)

HPA006294 HPA022046

Interaction Protein

ENSG00000107816

Interaction Count

Interaction Dataset

biogrid_opencell

Supporting Publications1

PMID	Title	Abstract
32560723	T2 and T17 cytokines alter the cargo and function of airway epithelium-derived extracellular vesicles.	No abstract available