Protein detail
LZTS1
Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer-related gene-coding leucine-zipper motif) (Fez1)
Entry name LZTS1 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer-related gene-coding leucine-zipper motif) (Fez1)
Protein Class
Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins
Protein Function
- Disease related genes
- Human disease related genes:Cancers:Cancers of the digestive system
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
FEZ1
Gene Description
Leucine zipper tumor suppressor 1
Chromosome
8
Position
20246165-20303963
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
- Disease related genes
- Human disease related genes:Cancers:Cancers of the digestive system
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Canonical Pathways
M108 Pid netrin pathway
Mediation Categories
Receptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
6 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture | Western blotting | 1 | 40098346 |
Sequence, Structure & Domains
Sequences
Length
596
Mass
66,613
Sequence
MGSVSSLISGHSFHSKHCRASQYKLRKSSHLKKLNRYSDGLLRFGFSQDSGHGKSSSKMGKSEDFFYIKVSQKARGSHHPDYTALSSGDLGGQAGVDFDPSTPPKLMPFSNQLEMGSEKGAVRPTAFKPVLPRSGAILHSSPESASHQLHPAPPDKPKEQELKPGLCSGALSDSGRNSMSSLPTHSTSSSYQLDPLVTPVGPTSRFGGSAHNITQGIVLQDSNMMSLKALSFSDGGSKLGHSNKADKGPSCVRSPISTDECSIQELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSYVAMYQRNQRLEKALQQLARGDSAGEPLEVDLEGADIPYEDIIATEI
Alternative Products
Event=Alternative splicing; Named isoforms=7; Name=1; IsoId=Q9Y250-1; Sequence=Displayed; Name=2; IsoId=Q9Y250-2; Sequence=VSP_009946; Name=3; IsoId=Q9Y250-3; Sequence=VSP_009945; Name=4; IsoId=Q9Y250-4; Sequence=VSP_009944; Name=5; IsoId=Q9Y250-5; Sequence=VSP_009943; Name=6; IsoId=Q9Y250-6; Sequence=VSP_009942; Name=7; IsoId=Q9Y250-7; Sequence=VSP_009940, VSP_009941
Alternative Sequence
55..76; SSSKMGKSEDFFYIKVSQKARG -> AMTRCPRASSMSGSCGRRRRRR (in isoform 7); 77..596; Missing (in isoform 7); 186..571; Missing (in isoform 6); 454..545; Missing (in isoform 5); 468..526; Missing (in isoform 4); 471..503; Missing (in isoform 3); 505..527; Missing (in isoform 2)
3D Structural Models
Helix
347..363; 364..367
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
153..162; Basic and acidic residues; 178..190; Low complexity; 295..310; Basic and acidic residues
Coiled Coil
256..374
Region
136..193; Disordered; 295..324; Disordered
Protein Families
LZTS family
Sequence Similarities
Belongs to the LZTS family.