Protein detail

PLAP

Phospholipase A-2-activating protein (PLA2P) (PLAP)

Entry name PLAP	UniProt ID Q9Y263	EVMP confidence score 0.38
Supporting publications (n) 2	Transmembrane count	Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Phospholipase A-2-activating protein (PLA2P) (PLAP)

Protein Class (4)

Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins

Protein Function (3)

Disease related genes
Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
Predicted intracellular proteins

Ensembl

ENSG00000137055

Entrez Gene Symbol

PLAA

Gene Synonym (5)

DOA1FLJ11281FLJ12699PLA2PPLAP

Gene Description

Phospholipase A2 activating protein

Chromosome

Position

26903372-26947242

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization3

Tissue SpecificesophagusCell SpecificBasal keratinocytesSingle-Nuclei Brain Specificendothelial cell

Function & Pathway6

Protein Function (3)

Disease related genes
Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
Predicted intracellular proteins

Cellular Component (4)

Molecular Function (3)

Biological Process (3)

KEGG

hsa04141 Protein processing in endoplasmic reticulum

Mediation Categories (3)

Fusion and delivery mediationImmune mediationMetabolism mediation

Relations & Evidence13

Ligand-Receptor Signaling (5)

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (7)

7 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
HT_SC_Cluster44	ANKZF1 NPLOC4 NSFL1C PLAA SVIP UBE4A UBE4B UBXN2A UBXN2B UFD1 VCP	O95155 P55072 P68543 Q14139 Q14CS0 Q8NHG7 Q8TAT6 Q92890 Q9H8Y5 Q9UNZ2 Q9Y263	1:1:1:1:1:1:1:1:1:1:1	Compleat	Compleat:HC261
VCP-PLAA AAA ATPase complex	PLAA VCP	P55072 Q9Y263	4:4	ComplexPortalPDB	intact:EBI-46424891PDB:3ebb	36825201 14755292 28819009 19887378
	KRAS PLAAT3	P01116 P53816	4:1	PDB	PDB:7c41
	PLAA UBC	P0CG48 Q9Y263	1:1	PDB	PDB:2k8cPDB:2k8b
	PLAAT3	P53816	2	PDB	PDB:4q95
	PLAAT4	Q9UL19	2	PDB	PDB:7zot
	NDRG2 PLAA	Q9UN36 Q9Y263	0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	9	28396511 36612172 37786918 28986585 27894104 31941606 38321535 39558134 37205098

Sequence, Structure & Domains12

Sequences

Length

795

Mass

87,157

Sequence

MTSGATRYRLSCSLRGHELDVRGLVCCAYPPGAFVSVSRDRTTRLWAPDSPNRSFTEMHCMSGHSNFVSCVCIIPSSDIYPHGLIATGGNDHNICIFSLDSPMPLYILKGHKNTVCSLSSGKFGTLLSGSWDTTAKVWLNDKCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLWKAGRCERTFSGHEDCVRGLAILSETEFLSCANDASIRRWQITGECLEVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIWKHGECAQTIRLPAQSIWCCCVLDNGDIVVGASDGIIRVFTESEDRTASAEEIKAFEKELSHATIDSKTGDLGDINAEQLPGREHLNEPGTREGQTRLIRDGEKVEAYQWSVSEGRWIKIGDVVGSSGANQQTSGKVLYEGKEFDYVFSIDVNEGGPSYKLPYNTSDDPWLTAYNFLQKNDLNPMFLDQVAKFIIDNTKGQMLGLGNPSFSDPFTGGGRYVPGSSGSSNTLPTADPFTGAGRYVPGSASMGTTMAGVDPFTGNSAYRSAASKTMNIYFPKKEAVTFDQANPTQILGKLKELNGTAPEEKKLTEDDLILLEKILSLICNSSSEKPTVQQLQILWKAINCPEDIVFPALDILRLSIKHPSVNENFCNEKEGAQFSSHLINLLNPKGKPANQLLALRTFCNCFVGQAGQKLMMSQRESLMSHAIELKSGSNKNIHIALATLALNYSVCFHKDHNIEGKAQCLSLISTILEVVQDLEATFRLLVALGTLISDDSNAVQLAKSLGVDSQIKKYSSVSEPAKVSECCRFILNLL

3D Structural Models

Turn

457..460; 607..609; 633..635

Helix

426..437; 443..455; 548..559; 564..566; 571..584; 593..603; 611..620; 624..631; 636..645; 653..665; 666..668; 670..678; 680..688; 689..691; 696..715; 719..733; 739..753; 757..765; 768..771; 772..777; 782..792

Beta Strand

390..392; 394..396; 399..407; 410..412; 416..420

3D Structure

NMR spectroscopy (4); X-ray crystallography (1)

Domain & Motif Annotations

Repeat

17..56; WD 1; 63..107; WD 2; 110..148; WD 3; 149..188; WD 4; 190..227; WD 5; 229..268; WD 6; 270..307; WD 7; 546..588; ARM 1; 589..620; ARM 2; 621..669; ARM 3; 670..715; ARM 4; 716..755; ARM 5; 756..795; ARM 6

Domain (CC)

The PUL domain is composed of 6 armadillo-like repeats and mediates the interaction with VCP C-terminus.; DOMAIN: The PFU domain mediates interaction with ubiquitin.

Domain (FT)

366..465; PFU; 533..794; PUL

Protein Families

WD repeat PLAP family

Sequence Similarities

Belongs to the WD repeat PLAP family.

Clinical Relevance5

Disease Involvement (2)

Disease variantIntellectual disability

Antibody (3)

CAB005035 HPA020994 HPA020996

Interaction Protein (3)

ENSG00000094631ENSG00000162191ENSG00000165280

Interaction Count

Interaction Dataset (3)

biogrid_bioplexintact_biogridintact_biogrid_opencell

Supporting Publications2

PMID	Title	Abstract
30646616	Preferential Localization of MUC1 Glycoprotein in Exosomes Secreted by Non-Small Cell Lung Carcinoma Cells.	THBS1, ANXA6, HIST1H4A, COL18A1, MDK, SRGN, ENO1, TUBA4A, SLC3A2, GPI, MIF, MUC1, TALDO1, SLC7A5, ICAM1, HSP90AA1, G6PD, and LRP1 were found to be expressed in exosomes at more than 5-fold higher level as compared to total cellular membrane proteins.
32089743	Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism.	No abstract available