Protein detail
TN13B
Tumor necrosis factor ligand superfamily member 13B (B lymphocyte stimulator) (BLyS) (B-cell-activating factor) (BAFF) (Dendritic cell-derived TNF-like molecule) (TNF- and APOL-related leukocyte expressed ligand 1) (TALL-1) (CD antigen CD257) [Cleaved into: Tumor necrosis factor ligand superfamily member 13b, membrane form; Tumor necrosis factor ligand superfamily member 13b, soluble form]
Protein symbol TN13B | UniProt ID | EVMP score 0.50 |
Frequency 8 | Transmembrane count 1 | Protein classification Cancer-related genesCD markersFDA approved drug targetsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteins |
Basic Information
Protein Names
Tumor necrosis factor ligand superfamily member 13B (B lymphocyte stimulator) (BLyS) (B-cell-activating factor) (BAFF) (Dendritic cell-derived TNF-like molecule) (TNF- and APOL-related leukocyte expressed ligand 1) (TALL-1) (CD antigen CD257) [Cleaved into: Tumor necrosis factor ligand superfamily member 13b, membrane form; Tumor necrosis factor ligand superfamily member 13b, soluble form]
Protein Class
Cancer-related genesCD markersFDA approved drug targetsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteins
Protein Function
- Predicted intracellular proteins
- CD markers
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
- FDA approved drug targets:Biotech drugs
Transmembrane
47..67; Helical; Signal-anchor for type II membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
BAFFBLYSCD257TALL-1TALL1THANKTNFSF20
Gene Description
TNF superfamily member 13b
Chromosome
13
Position
108251240-108308484
Frequency
8
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecifictestisCell SpecificCardiomyocytes
Function & Pathway
Protein Function
- Predicted intracellular proteins
- CD markers
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
- FDA approved drug targets:Biotech drugs
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
64 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | TopDB | No | No | Yes | No | No |
| transmembrane | transmembrane | LOCATE | No | No | Yes | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | Yes | No | No |
| transmembrane | transmembrane | OmniPath | No | No | Yes | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | Yes | No | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | Yes | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | Yes | No | No |
| secreted | secreted | UniProt_keyword | No | No | Yes | No | No |
| secreted | secreted | HPA_secretome | No | No | Yes | No | No |
| secreted | secreted | connectomeDB2020 | No | No | Yes | No | No |
Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| TN13B | Q9Y275 | TR13C | Q96RJ3 | Yes | Yes | No | iTALKGuide2Pharma_LRdbICELLNETSIGNORHINTInnateDBUniProt_LRdbHPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrscConnectHPRDRamilowski2015_Baccin2019Guide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACECellCallGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb | ICELLNET:11239407connectomeDB2020:15851487HINT:12755599HINT:12721620HINT:12571250Baccin2019:15851487LRdb:15851487CellTalkDB:15851487LRdb:12721620Baccin2019:12721620HINT:12715002HPRD:12721620InnateDB:12571250HINT:22505257Cellinker:12721620Baccin2019:11509692SIGNOR:15644327LRdb:11509692connectomeDB2020:12721620connectomeDB2020:11509692HPRD:11509692SIGNOR:15851487Cellinker:11509692HPMR:15851487Cellinker:15851487 |
| TN13B | Q9Y275 | TR13B | O14836 | Yes | Yes | No | iTALKGuide2Pharma_LRdbICELLNETSIGNORHINTUniProt_LRdbDIPLit-BM-17HPMR_talklrCellChatDBHPRD_LRdbtalklrscConnectHPRDIntActRamilowski2015_Baccin2019Guide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACEGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020SPIKE_LCLRdb | ICELLNET:11239407SPIKE_LC:17145710CellTalkDB:10956646IntAct:10956646IntAct:10801128HINT:10880535IntAct:10880535LRdb:10956646Baccin2019:10801128HPRD:10801128Lit-BM-17:10801128LRdb:11HINT:10956646Lit-BM-17:10956646SPIKE_LC:10801128DIP:10956646Lit-BM-17:10880535HINT:10801128Cellinker:10956646connectomeDB2020:10801128SIGNOR:10956646connectomeDB2020:10956646Cellinker:10801128Baccin2019:10956646 |
Protein Complex Composition
6 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| TALL1 homo-oligomer complex | TNFSF13B | Q9Y275 | 10 | CORUMPDB | PDB:1kxgPDB:4zchPDB:1kd7CORUM:5691PDB:6fxnPDB:1jh5PDB:1osg | 14749821 |
| FAM118AFHIP2AMAP3K15MAP3K5MAP3K6PDSS1TNFSF13B | O95382Q5T2R2Q5W0V3Q6ZN16Q99683Q9NWS6Q9Y275 | 0:0:0:0:0:0:0 | hu.MAP | |||
| FHIP2AHOOK2MAP3K15MAP3K5TNFSF13B | Q5W0V3Q6ZN16Q96ED9Q99683Q9Y275 | 0:0:0:0:0 | hu.MAP2 | |||
| FHIP2AMAP3K15MAP3K5TNFSF13B | Q5W0V3Q6ZN16Q99683Q9Y275 | 0:0:0:0 | hu.MAP | |||
| FAM118AMAP3K15MAP3K5TNFSF13B | Q6ZN16Q99683Q9NWS6Q9Y275 | 0:0:0:0 | hu.MAP | |||
| TNFRSF13CTNFSF13B | Q96RJ3Q9Y275 | 8:10 | PDB | PDB:4v46PDB:8zujPDB:3v56PDB:1oqe |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Mass spectrometry | 1 | 38343172 |
Sequence, Structure & Domains
Sequences
Length
285
Mass
31,223
Sequence
MDDSTEREQSRLTSCLKKREEMKLKECVSILPRKESPSVRSSKDGKLLAATLLLALLSCCLTVVSFYQVAALQGDLASLRAELQGHHAEKLPAGAGAPKAGLEEAPAVTAGLKIFEPPAPGEGNSSQNSRNKRAVQGPEETVTQDCLQLIADSETPTIQKGSYTFVPWLLSFKRGSALEEKENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVHVFGDELSLVTLFRCIQNMPETLPNNSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVTFFGALKLL
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9Y275-1; Sequence=Displayed; Name=2; Synonyms=DeltaBAFF; IsoId=Q9Y275-2; Sequence=VSP_041183; Name=3; Synonyms=Delta4BAFF; IsoId=Q9Y275-3; Sequence=VSP_047591, VSP_047592
Alternative Sequence
142..160; Missing (in isoform 2); 162..164; SYT -> FIY (in isoform 3); 165..285; Missing (in isoform 3)
3D Structural Models
Turn
219..222; 274..276
Beta Strand
146..151; 158..160; 163..165; 168..181; 184..187; 191..201; 205..215; 225..235; 238..240; 243..253; 258..265; 277..283
3D Structure
Electron microscopy (1); X-ray crystallography (11)
Domain & Motif Annotations
Domain (FT)
145..284; THD
Region
114..138; Disordered
Protein Families
Tumor necrosis factor family
Sequence Similarities
Belongs to the tumor necrosis factor family.
Clinical Relevance
Disease Involvement
Cancer-related genesFDA approved drug targets
Biomarker
Approved; Discontinued in Phase 1; Phase 3; Discontinued in Phase 2
Drug Targets
FDA approved drug targets
Interaction Protein
ENSG00000108424ENSG00000124207ENSG00000240505
Interaction Count
3
Interaction Dataset
intact_biogrid