Protein detail
TN13B
Tumor necrosis factor ligand superfamily member 13B (B lymphocyte stimulator) (BLyS) (B-cell-activating factor) (BAFF) (Dendritic cell-derived TNF-like molecule) (TNF- and APOL-related leukocyte expressed ligand 1) (TALL-1) (CD antigen CD257) [Cleaved into: Tumor necrosis factor ligand superfamily member 13b, membrane form; Tumor necrosis factor ligand superfamily member 13b, soluble form]
Entry name TN13B | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 8 | Transmembrane count 1 | Protein classification Cancer-related genesCD markersFDA approved drug targetsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Tumor necrosis factor ligand superfamily member 13B (B lymphocyte stimulator) (BLyS) (B-cell-activating factor) (BAFF) (Dendritic cell-derived TNF-like molecule) (TNF- and APOL-related leukocyte expressed ligand 1) (TALL-1) (CD antigen CD257) [Cleaved into: Tumor necrosis factor ligand superfamily member 13b, membrane form; Tumor necrosis factor ligand superfamily member 13b, soluble form]
Protein Class (7)
Cancer-related genesCD markersFDA approved drug targetsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteins
Protein Function (5)
- Predicted intracellular proteins
- CD markers
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
- FDA approved drug targets:Biotech drugs
Transmembrane
47..67; Helical; Signal-anchor for type II membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (7)
BAFFBLYSCD257TALL-1TALL1THANKTNFSF20
Gene Description
TNF superfamily member 13b
Chromosome
13
Position
108251240-108308484
Supporting publications (n)
8
EVMP confidence score
0.38
Fluorescence & Localization
Tissue SpecifictestisCell SpecificCardiomyocytes
Function & Pathway
Protein Function (5)
- Predicted intracellular proteins
- CD markers
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
- FDA approved drug targets:Biotech drugs
Cellular Component (8)
Molecular Function (5)
Biological Process (3)
KEGG (4)
Reactome (4)
Mediation Categories (3)
Adhesion and uptake mediationClinical-translation mediationImmune mediation
Relations & Evidence73
Ligand-Receptor Signaling (64)
64 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane_predicted | Phobius | Yes | ||||
| transmembrane_phobius | transmembrane_predicted | Almen2009 | Yes | ||||
| transmembrane_sosui | transmembrane_predicted | Almen2009 | Yes | ||||
| transmembrane_tmhmm | transmembrane_predicted | Almen2009 | Yes |
Page 7 of 7Previous
Regulatory Interaction Network (2)
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| TN13B | Q9Y275 | TR13C | Q96RJ3 | Yes | Yes | iTALKGuide2Pharma_LRdbICELLNETSIGNORHINTInnateDBUniProt_LRdbHPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrscConnectHPRDRamilowski2015_Baccin2019Guide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACECellCallGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb | ICELLNET:11239407connectomeDB2020:15851487HINT:12755599HINT:12721620HINT:12571250Baccin2019:15851487LRdb:15851487CellTalkDB:15851487LRdb:12721620Baccin2019:12721620HINT:12715002HPRD:12721620InnateDB:12571250HINT:22505257Cellinker:12721620Baccin2019:11509692SIGNOR:15644327LRdb:11509692connectomeDB2020:12721620connectomeDB2020:11509692HPRD:11509692SIGNOR:15851487Cellinker:11509692HPMR:15851487Cellinker:15851487 | |
| TN13B | Q9Y275 | TR13B | O14836 | Yes | Yes | iTALKGuide2Pharma_LRdbICELLNETSIGNORHINTUniProt_LRdbDIPLit-BM-17HPMR_talklrCellChatDBHPRD_LRdbtalklrscConnectHPRDIntActRamilowski2015_Baccin2019Guide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACEGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020SPIKE_LCLRdb | ICELLNET:11239407SPIKE_LC:17145710CellTalkDB:10956646IntAct:10956646IntAct:10801128HINT:10880535IntAct:10880535LRdb:10956646Baccin2019:10801128HPRD:10801128Lit-BM-17:10801128LRdb:11HINT:10956646Lit-BM-17:10956646SPIKE_LC:10801128DIP:10956646Lit-BM-17:10880535HINT:10801128Cellinker:10956646connectomeDB2020:10801128SIGNOR:10956646connectomeDB2020:10956646Cellinker:10801128Baccin2019:10956646 |
Protein Complex Composition (6)
6 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| TALL1 homo-oligomer complex | TNFSF13B | Q9Y275 | 10 | CORUMPDB | PDB:1kxgPDB:4zchPDB:1kd7CORUM:5691PDB:6fxnPDB:1jh5PDB:1osg | 14749821 |
| FAM118AFHIP2AMAP3K15MAP3K5MAP3K6PDSS1TNFSF13B | O95382Q5T2R2Q5W0V3Q6ZN16Q99683Q9NWS6Q9Y275 | 0:0:0:0:0:0:0 | hu.MAP | |||
| FHIP2AHOOK2MAP3K15MAP3K5TNFSF13B | Q5W0V3Q6ZN16Q96ED9Q99683Q9Y275 | 0:0:0:0:0 | hu.MAP2 | |||
| FHIP2AMAP3K15MAP3K5TNFSF13B | Q5W0V3Q6ZN16Q99683Q9Y275 | 0:0:0:0 | hu.MAP | |||
| FAM118AMAP3K15MAP3K5TNFSF13B | Q6ZN16Q99683Q9NWS6Q9Y275 | 0:0:0:0 | hu.MAP | |||
| TNFRSF13CTNFSF13B | Q96RJ3Q9Y275 | 8:10 | PDB | PDB:4v46PDB:8zujPDB:3v56PDB:1oqe |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Mass spectrometry | 1 | 38343172 |
Sequence, Structure & Domains
Sequences
Length
285
Mass
31,223
Sequence
MDDSTEREQSRLTSCLKKREEMKLKECVSILPRKESPSVRSSKDGKLLAATLLLALLSCCLTVVSFYQVAALQGDLASLRAELQGHHAEKLPAGAGAPKAGLEEAPAVTAGLKIFEPPAPGEGNSSQNSRNKRAVQGPEETVTQDCLQLIADSETPTIQKGSYTFVPWLLSFKRGSALEEKENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVHVFGDELSLVTLFRCIQNMPETLPNNSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVTFFGALKLL
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9Y275-1; Sequence=Displayed; Name=2; Synonyms=DeltaBAFF; IsoId=Q9Y275-2; Sequence=VSP_041183; Name=3; Synonyms=Delta4BAFF; IsoId=Q9Y275-3; Sequence=VSP_047591, VSP_047592
Alternative Sequence
142..160; Missing (in isoform 2); 162..164; SYT -> FIY (in isoform 3); 165..285; Missing (in isoform 3)
3D Structural Models
Turn
219..222; 274..276
Beta Strand
146..151; 158..160; 163..165; 168..181; 184..187; 191..201; 205..215; 225..235; 238..240; 243..253; 258..265; 277..283
3D Structure
Electron microscopy (1); X-ray crystallography (11)
Domain & Motif Annotations
Domain (FT)
145..284; THD
Region
114..138; Disordered
Protein Families
Tumor necrosis factor family
Sequence Similarities
Belongs to the tumor necrosis factor family.
Clinical Relevance
Disease Involvement (2)
Cancer-related genesFDA approved drug targets
Related Diseases (5)
Biomarker
Approved; Discontinued in Phase 1; Phase 3; Discontinued in Phase 2
Drug Targets
FDA approved drug targets
Interaction Protein (3)
ENSG00000108424ENSG00000124207ENSG00000240505
Interaction Count
3
Interaction Dataset
intact_biogrid
Supporting Publications8
| PMID | Title | Related sentences |
|---|---|---|
| 26826536 | [Cardiovascular risk study in patients with renin-angiotensin system blockade by means of the proteone of circulating extracellular vesicles]. | No related sentences available |
| 34064677 | Ubiquinone Metabolism and Transcription HIF-1 Targets Pathway Are Toxicity Signature Pathways Present in Extracellular Vesicles of Paraquat-Exposed Human Brain Microvascular Endothelial Cells. | No related sentences available |
| 37322475 | Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration. | No related sentences available |
| 38113368 | In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum. | No related sentences available |
| 38207106 | Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity. | No related sentences available |
| 39207047 | The trajectory of vesicular proteomic signatures from HBV-HCC by chitosan-magnetic bead-based separation and DIA-proteomic analysis. | No related sentences available |
| 40840701 | Multiomics analysis to evaluate the enrichment of extracellular vesicles from human plasma. | No related sentences available |
| 41307968 | Extracellular Vesicles Define Discrete Nano-Based Niches Within the Human Haematopoietic System. | No related sentences available |