Protein detail

VSIG4

V-set and immunoglobulin domain-containing protein 4 (Protein Z39Ig)

Entry name VSIG4	UniProt ID Q9Y279	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count 1	Protein classification Plasma proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information12

Protein Names

V-set and immunoglobulin domain-containing protein 4 (Protein Z39Ig)

Protein Class (2)

Plasma proteinsPredicted membrane proteins

Transmembrane

284..304; Helical

Transmembrane Count

Ensembl

ENSG00000155659

Entrez Gene Symbol

VSIG4

Gene Synonym (2)

CRIgZ39IG

Gene Description

V-set and immunoglobulin domain containing 4

Chromosome

Position

66021738-66040125

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization5

Cell SpecificExtravillous trophoblastsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificeosinophilSecretome LocationSecreted to blood

Function & Pathway6

Cellular Component (2)

Molecular Function (2)

Biological Process (3)

KEGG

hsa04610 Complement and coagulation cascades

Canonical Pathways (2)

M243 Pid arf 3pathway
M281 Pid fak pathway

Mediation Categories (2)

Adhesion and uptake mediationImmune mediation

Relations & Evidence23

Ligand-Receptor Signaling (21)

21 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	No	Yes	No
adhesion	adhesion	OmniPath	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane_predicted	transmembrane	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane	TopDB	No	No	No	Yes	No

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	C3 VSIG4	P01024 Q9Y279	6:2	PDB	PDB:2icfPDB:2ice

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Western blotting	3	38731868 33709510 40098346

Sequence, Structure & Domains10

Sequences

Length

399

Mass

43,987

Sequence

MGILLGLLLLGHLTVDTYGRPILEVPESVTGPWKGDVNLPCTYDPLQGYTQVLVKWLVQRGSDPVTIFLRDSSGDHIQQAKYQGRLHVSHKVPGDVSLQLSTLEMDDRSHYTCEVTWQTPDGNQVVRDKITELRVQKLSVSKPTVTTGSGYGFTVPQGMRISLQCQARGSPPISYIWYKQQTNNQEPIKVATLSTLLFKPAVIADSGSYFCTAKGQVGSEQHSDIVKFVVKDSSKLLKTKTEAPTTMTYPLKATSTVKQSWDWTTDMDGYLGETSAGPGKSLPVFAIILIISLCCMVVFTMAYIMLCRKTSQQEHVYEAARAHAREANDSGETMRVAIFASGCSSDEPTSQNLGNNYSDEPCIGQEYQIIAQINGNYARLLDTVPLDYEFLATEGKSVC

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9Y279-1; Sequence=Displayed; Name=2; IsoId=Q9Y279-2; Sequence=VSP_012813; Name=3; IsoId=Q9Y279-3; Sequence=VSP_041213

Alternative Sequence

138..232; LSVSKPTVTTGSGYGFTVPQGMRISLQCQARGSPPISYIWYKQQTNNQEPIKVATLSTLLFKPAVIADSGSYFCTAKGQVGSEQHSDIVKFVVKD -> H (in isoform 3); 322..399; Missing (in isoform 2)

3D Structural Models

Turn

83..85

Helix

80..82; 105..107

Beta Strand

22..24; 27..32; 37..39; 50..58; 60..63; 65..71; 74..77; 86..88; 98..100; 109..118; 124..136

3D Structure

X-ray crystallography (7)

Domain & Motif Annotations

Domain (FT)

21..131; Ig-like 1; 143..226; Ig-like 2

Clinical Relevance1

Antibody (3)

HPA003903 CAB026000 HPA072756

Supporting Publications1

PMID	Title	Abstract
40098346	Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays.	No abstract available