Protein detail

ITM2B

Integral membrane protein 2B (Immature BRI2) (imBRI2) (Protein E25B) (Transmembrane protein BRI) (Bri) [Cleaved into: BRI2, membrane form (Mature BRI2) (mBRI2); BRI2 intracellular domain (BRI2 ICD); BRI2C, soluble form; Bri23 peptide (Bri2-23) (ABri23) (C-terminal peptide) (P23 peptide)]

Entry name
ITM2B
UniProt ID
Q9Y287
EVMP confidence score
0.47
Supporting publications (n)
16
Transmembrane count
1
Protein classification
Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteinsTransporters
EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information13
Protein Names
Integral membrane protein 2B (Immature BRI2) (imBRI2) (Protein E25B) (Transmembrane protein BRI) (Bri) [Cleaved into: BRI2, membrane form (Mature BRI2) (mBRI2); BRI2 intracellular domain (BRI2 ICD); BRI2C, soluble form; Bri23 peptide (Bri2-23) (ABri23) (C-terminal peptide) (P23 peptide)]
Protein Class (7)
Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteinsTransporters
Protein Function (7)
  • Predicted intracellular proteins
  • Human disease related genes:Nervous system diseases:Neurodegenerative diseases
  • Human disease related genes:Congenital malformations:Congenital malformations of eye
  • Potential drug targets
  • Transporters:Transporter channels and pores
  • Predicted secreted proteins
  • Disease related genes
Transmembrane
55..75; Helical; Signal-anchor for type II membrane protein
Transmembrane Count
1
Ensembl
ENSG00000136156
Entrez Gene Symbol
ITM2B
Gene Synonym (5)
BRIBRI2BRICD2BE25BE3-16
Gene Description
Integral membrane protein 2B
Chromosome
13
Position
48232612-48270357
Supporting publications (n)
16
EVMP confidence score
0.47
Fluorescence & Localization5
ITM2B fluorescence
Tissue Specificbone marrowCell SpecificcDCSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificneutrophil
Function & Pathway6
Protein Function (7)
  • Predicted intracellular proteins
  • Human disease related genes:Nervous system diseases:Neurodegenerative diseases
  • Human disease related genes:Congenital malformations:Congenital malformations of eye
  • Potential drug targets
  • Transporters:Transporter channels and pores
  • Predicted secreted proteins
  • Disease related genes
Cellular Component (11)
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Molecular Function (3)
Biological Process (3)
Reactome
R-hsa-977225 amyloid fiber formation
Mediation Categories (2)
Fusion and delivery mediationMetabolism mediation
Relations & Evidence32

Ligand-Receptor Signaling (29)

29 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
transmembranetransmembraneUniProt_locationNoNoYesYesNo
transmembranetransmembraneUniProt_topologyNoNoYesYesNo
transmembranetransmembraneUniProt_keywordNoNoYesYesNo
transmembrane_predictedtransmembraneOmniPathNoNoYesYesNo
transmembranetransmembraneTopDBNoNoYesYesNo
transmembranetransmembraneRamilowski_locationNoNoYesYesNo
transmembranetransmembraneOmniPathNoNoYesYesNo
plasma_membraneplasma_membraneCellinkerNoNoYesYesNo
plasma_membraneplasma_membraneOmniPathNoNoYesYesNo
plasma_membrane_transmembraneplasma_membrane_transmembraneCSPANoNoYesYesNo
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Protein Complex Composition (2)

2 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
B4GALNT1ITM2BQ00973Q9Y2870:0hu.MAP
ITM2BQ9Y28712PDBPDB:8rnu

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity CaptureMass spectrometry23811336838716512
Sequence, Structure & Domains13

Sequences

Length
266
Mass
30,338
Sequence
MVKVTFNSALAQKEAKKDEPKSGEEALIIPPDAVAVDCKDPDDVVPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFALQPDDVYYCGIKYIKDDVILNEPSADAPAALYQTIEENIKIFEEEEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPRNLLELLINIKAGTYLPQSYLIHEHMVITDRIENIDHLGFFIYRLCHDKETYKLQRRETIKGIQKREASNCFAIRHFENKFAVETLICS
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y287-1; Sequence=Displayed; Name=2; IsoId=Q9Y287-2; Sequence=VSP_055326
Alternative Sequence
83..188; Missing (in isoform 2)

3D Structural Models

Turn
123..126; 149..152; 159..162
Helix
180..185; 217..222
Beta Strand
118..122; 127..132; 136..139; 143..148; 153..156; 164..168; 227..230
3D Structure
Electron microscopy (1)

Domain & Motif Annotations

Domain (FT)
137..231; BRICHOS
Region
102..134; Necessary for interaction with APP and inhibitor effects on APP processing
Protein Families
ITM2 family
Sequence Similarities
Belongs to the ITM2 family.
Clinical Relevance2
Disease Involvement (4)
AmyloidosisDeafnessDisease variantNeurodegeneration
Antibody (2)
HPA029292HPA071992
Supporting Publications16
PMIDTitleAbstract
38014595Proteome and immune responses of extracellular vesicles derived from macrophages infected with the periodontal pathogen Tannerella forsythia.No abstract available
38113368In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.No abstract available
38207106Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.No abstract available
38590132Proteomic Identification of Small Extracellular Vesicle Proteins LAMB1 and Histone H4 for Prostate Cancer Diagnosis and Risk Stratification.No abstract available
39001700Optimized AF4 combined with density cushion ultracentrifugation enables profiling of high-purity human blood extracellular vesicles.No abstract available
41068253Identification of plasma extracellular vesicle protein biomarkers in diabetic retinopathy progression.No abstract available
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