Protein detail
SC5A6
Sodium-dependent multivitamin transporter (Na(+)-dependent multivitamin transporter) (hSMVT) (Solute carrier family 5 member 6)
Entry name SC5A6 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 13 | Protein classification Disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Sodium-dependent multivitamin transporter (Na(+)-dependent multivitamin transporter) (hSMVT) (Solute carrier family 5 member 6)
Protein Class
Disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
- Predicted intracellular proteins
- Potential drug targets
Transmembrane
24..44; Helical; 68..88; Helical; 101..121; Helical; 143..163; Helical; 176..196; Helical; 199..219; Helical; 256..276; Helical; 297..317; Helical; 336..356; Helical; 396..416; Helical; 428..448; Helical; 456..476; Helical; 528..548; Helical
Transmembrane Count
13
Ensembl
Entrez Gene Symbol
Gene Synonym
SMVT
Gene Description
Solute carrier family 5 member 6
Chromosome
2
Position
27199587-27212958
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificbone marrowCell SpecificErythrocyte progenitorsSingle-Nuclei Brain SpecificleukocyteBlood Cell Specificnon-classical monocyte
Function & Pathway
Protein Function
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
- Predicted intracellular proteins
- Potential drug targets
Cellular Component
Molecular Function
- GO:0005515 protein binding
- GO:0008523 sodium-dependent multivitamin transmembrane transporter activity
- GO:0015111 iodide transmembrane transporter activity
- GO:0015225 biotin transmembrane transporter activity
- GO:0015233 pantothenate transmembrane transporter activity
- GO:0015498 pantothenate:sodium symporter activity
- GO:0090482 vitamin transmembrane transporter activity
- GO:0140161 monocarboxylate:sodium symporter activity
Biological Process
Reactome
- R-hsa-196780 biotin transport and metabolism
- R-hsa-196854 metabolism of vitamins and cofactors
- R-hsa-196849 metabolism of water soluble vitamins and cofactors
- R-hsa-425407 slc mediated transmembrane transport
- R-hsa-382551 transport of small molecules
- R-hsa-425397 transport of vitamins nucleosides and related molecules
- R-hsa-199220 vitamin b5 pantothenate metabolism
Mediation Categories
Clinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
21 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| apical_cell_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | No | No |
| cell_surface | cell_surface | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation；Acoustic trapping | Mass spectrometry | 1 | 27487081 |
Sequence, Structure & Domains
Sequences
Length
635
Mass
68,642
Sequence
MSVGVSTSAPLSPTSGTSVGMSTFSIMDYVVFVLLLVLSLAIGLYHACRGWGRHTVGELLMADRKMGCLPVALSLLATFQSAVAILGVPSEIYRFGTQYWFLGCCYFLGLLIPAHIFIPVFYRLHLTSAYEYLELRFNKTVRVCGTVTFIFQMVIYMGVVLYAPSLALNAVTGFDLWLSVLALGIVCTVYTALGGLKAVIWTDVFQTLVMFLGQLAVIIVGSAKVGGLGRVWAVASQHGRISGFELDPDPFVRHTFWTLAFGGVFMMLSLYGVNQAQVQRYLSSRTEKAAVLSCYAVFPFQQVSLCVGCLIGLVMFAYYQEYPMSIQQAQAAPDQFVLYFVMDLLKGLPGLPGLFIACLFSGSLSTISSAFNSLATVTMEDLIRPWFPEFSEARAIMLSRGLAFGYGLLCLGMAYISSQMGPVLQAAISIFGMVGGPLLGLFCLGMFFPCANPPGAVVGLLAGLVMAFWIGIGSIVTSMGSSMPPSPSNGSSFSLPTNLTVATVTTLMPLTTFSKPTGLQRFYSLSYLWYSAHNSTTVIVVGLIVSLLTGRMRGRSLNPATIYPVLPKLLSLLPLSCQKRLHCRSYGQDHLDTGLFPEKPRNGVLGDSRDKEAMALDGTAYQGSSSTCILQETSL
3D Structural Models
Domain & Motif Annotations
Domain (CC)
The C-terminal tail is important for biotin uptake as well as apical localization in polarized cells.
Protein Families
Sodium:solute symporter (SSF) (TC 2.A.21) family
Sequence Similarities
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
Clinical Relevance
Disease Involvement
Disease variantNeurodegenerationNeuropathy
Related Diseases
Biomarker
Phase 2
Drugs
Antibody
Interaction Protein
ENSG00000168961
Interaction Count
1
Interaction Dataset
biogrid_bioplex