Protein detail

SL9A8

Sodium/hydrogen exchanger 8 (Na(+)/H(+) exchanger 8) (NHE-8) (Solute carrier family 9 member 8)

Protein symbol
SL9A8
UniProt ID
EVMP score
0.38
Frequency
Transmembrane count
11
Protein classification
Metabolic proteinsPlasma proteinsPredicted membrane proteinsTransporters
Basic Information
Protein Names
Sodium/hydrogen exchanger 8 (Na(+)/H(+) exchanger 8) (NHE-8) (Solute carrier family 9 member 8)
Protein Class
Metabolic proteinsPlasma proteinsPredicted membrane proteinsTransporters
Protein Function
Transporters:Electrochemical Potential-driven transporters
Transmembrane
60..80; Helical; 84..104; Helical; 123..143; Helical; 156..176; Helical; 191..211; Helical; 264..284; Helical; 311..331; Helical; 354..374; Helical; 379..399; Helical; 417..437; Helical; 451..471; Helical
Transmembrane Count
11
Entrez Gene Symbol
Gene Synonym
KIAA0939NHE8
Gene Description
Solute carrier family 9 member A8
Chromosome
20
Position
49812713-49892242
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecificbreastCell SpecificDecidual stromal cellsSingle-Nuclei Brain SpecificfibroblastBlood Cell Specificmemory B-cellBlood Lineage SpecificB-cellsSecretome LocationSecreted to bloodSecretome FunctionApolipoprotein
Function & Pathway
Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

16 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
transmembranetransmembraneOmniPathNoNoNoNoNo
plasma_membraneplasma_membraneUniProt_locationNoNoNoNoNo
apical_cell_membraneplasma_membraneUniProt_locationNoNoNoNoNo
plasma_membraneplasma_membraneOmniPathNoNoNoNoNo
receptorreceptorscConnectNoYesNoNoNo
transmembranetransmembrane_predictedPhobiusNoNoNoNoNo
Page 2 of 2Previous

Regulatory Interaction Network

0 records.

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity CaptureMass spectrometry53606464738113368401894973256072336146834
Sequence, Structure & Domains

Sequences

Length
581
Mass
65,422
Sequence
MGEKMAEEERFPNTTHEGFNVTLHTTLVVTTKLVLPTPGKPILPVQTGEQAQQEEQSSGMTIFFSLLVLAICIILVHLLIRYRLHFLPESVAVVSLGILMGAVIKIIEFKKLANWKEEEMFRPNMFFLLLLPPIIFESGYSLHKGNFFQNIGSITLFAVFGTAISAFVVGGGIYFLGQADVISKLNMTDSFAFGSLISAVDPVATIAIFNALHVDPVLNMLVFGESILNDAVSIVLTNTAEGLTRKNMSDVSGWQTFLQALDYFLKMFFGSAALGTLTGLISALVLKHIDLRKTPSLEFGMMIIFAYLPYGLAEGISLSGIMAILFSGIVMSHYTHHNLSPVTQILMQQTLRTVAFLCETCVFAFLGLSIFSFPHKFEISFVIWCIVLVLFGRAVNIFPLSYLLNFFRDHKITPKMMFIMWFSGLRGAIPYALSLHLDLEPMEKRQLIGTTTIVIVLFTILLLGGSTMPLIRLMDIEDAKAHRRNKKDVNLSKTEKMGNTVESEHLSELTEEEYEAHYIRRQDLKGFVWLDAKYLNPFFTRRLTQEDLHHGRIQMKTLTNKWYEEVRQGPSGSEDDEQELL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y2E8-1; Sequence=Displayed; Name=2; IsoId=Q9Y2E8-2; Sequence=VSP_037686
Alternative Sequence
178; Q -> QGFFFVCVCVFVCFILQ (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Protein Families
Monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family
Sequence Similarities
Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
Clinical Relevance