Protein detail

TBC30

TBC1 domain family member 30

Entry name TBC30	UniProt ID Q9Y2I9	EVMP confidence score 0.50
Supporting publications (n) 3	Transmembrane count	Protein classification Predicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

TBC1 domain family member 30

Protein Class (2)

Predicted intracellular proteinsPredicted membrane proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000111490

Entrez Gene Symbol

TBC1D30

Gene Synonym

KIAA0984

Gene Description

TBC1 domain family member 30

Chromosome

Position

64759484-64881033

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization4

Tissue Specificblood vesselCell SpecificEarly spermatidsSingle-Nuclei Brain Specificvascular associated smooth muscle cellBlood Cell Specificnon-classical monocyte

Function & Pathway5

Protein Function

Predicted intracellular proteins

Cellular Component (4)

Molecular Function (3)

Biological Process (3)

Mediation Categories

Receptor-signaling mediation

Relations & Evidence8

Ligand-Receptor Signaling (5)

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	CCDC184 EURL FEZ2 HEATR5A PAWR SCHIP1 SCOC TBC1D30	P0DPB3 Q52MB2 Q86XA9 Q96IZ0 Q9NYK6 Q9UHY8 Q9UIL1 Q9Y2I9	0:0:0:0:0:0:0:0	hu.MAP2
	EURL FEZ2 SCHIP1 SCOC TBC1D30	P0DPB3 Q9NYK6 Q9UHY8 Q9UIL1 Q9Y2I9	0:0:0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration	Mass spectrometry	1	40595564

Sequence, Structure & Domains8

Sequences

Length

924

Mass

102,743

Sequence

MDVLPTGGGRPGLRTELEFRGGGGEARLESQEEETIPAAPPAPRLRGAAERPRRSRDTWDGDEDTEPGEACGGRTSRTASLVSGLLNELYSCTEEEEAAGGGRGAEGRRRRRDSLDSSTEASGSDVVLGGRSGAGDSRVLQELQERPSQRHQMLYLRQKDANELKTILRELKYRIGIQSAKLLRHLKQKDRLLHKVQRNCDIVTACLQAVSQKRRVDTKLKFTLEPSLGQNGFQQWYDALKAVARLSTGIPKEWRRKVWLTLADHYLHSIAIDWDKTMRFTFNERSNPDDDSMGIQIVKDLHRTGCSSYCGQEAEQDRVVLKRVLLAYARWNKTVGYCQGFNILAALILEVMEGNEGDALKIMIYLIDKVLPESYFVNNLRALSVDMAVFRDLLRMKLPELSQHLDTLQRTANKESGGGYEPPLTNVFTMQWFLTLFATCLPNQTVLKIWDSVFFEGSEIILRVSLAIWAKLGEQIECCETADEFYSTMGRLTQEMLENDLLQSHELMQTVYSMAPFPFPQLAELREKYTYNITPFPATVKPTSVSGRHSKARDSDEENDPDDEDAVVNAVGCLGPFSGFLAPELQKYQKQIKEPNEEQSLRSNNIAELSPGAINSCRSEYHAAFNSMMMERMTTDINALKRQYSRIKKKQQQQVHQVYIRADKGPVTSILPSQVNSSPVINHLLLGKKMKMTNRAAKNAVIHIPGHTGGKISPVPYEDLKTKLNSPWRTHIRVHKKNMPRTKSHPGCGDTVGLIDEQNEASKTNGLGAAEAFPSGCTATAGREGSSPEGSTRRTIEGQSPEPVFGDADVDVSAVQAKLGALELNQRDAAAETELRVHPPCQRHCPEPPSAPEENKATSKAPQGSNSKTPIFSPFPSVKPLRKSATARNLGLYGPTERTPTVHFPQMSRSFSKPGGGNSGTKKR

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9Y2I9-1; Sequence=Displayed; Name=2; IsoId=Q9Y2I9-2; Sequence=VSP_042427; Name=3; IsoId=Q9Y2I9-3; Sequence=VSP_042427, VSP_042428; Name=4; IsoId=Q9Y2I9-4; Sequence=VSP_062258

Alternative Sequence

1..277; Missing (in isoform 4); 1..215; MDVLPTGGGRPGLRTELEFRGGGGEARLESQEEETIPAAPPAPRLRGAAERPRRSRDTWDGDEDTEPGEACGGRTSRTASLVSGLLNELYSCTEEEEAAGGGRGAEGRRRRRDSLDSSTEASGSDVVLGGRSGAGDSRVLQELQERPSQRHQMLYLRQKDANELKTILRELKYRIGIQSAKLLRHLKQKDRLLHKVQRNCDIVTACLQAVSQKRR -> MRQDKLTGSLRRGGRCLKRQGGGVGTILSNVLKKRSCISRTAPRLLCTLEPG (in isoform 2 and isoform 3); 792..924; TRRTIEGQSPEPVFGDADVDVSAVQAKLGALELNQRDAAAETELRVHPPCQRHCPEPPSAPEENKATSKAPQGSNSKTPIFSPFPSVKPLRKSATARNLGLYGPTERTPTVHFPQMSRSFSKPGGGNSGTKKR -> SSYKSLQMI (in isoform 3)

Domain & Motif Annotations

Compositional Bias

1..11; Gly residues; 47..59; Basic and acidic residues; 555..564; Acidic residues; 858..870; Polar residues; 914..924; Gly residues

Domain (FT)

249..457; Rab-GAP TBC

Region

1..76; Disordered; 94..134; Disordered; 541..564; Disordered; 776..806; Disordered; 838..924; Disordered

Clinical Relevance1

Antibody (2)

HPA039772 HPA040043

Supporting Publications3

PMID	Title	Abstract
36064647	Systemic proteomics and miRNA profile analysis of exosomes derived from human pluripotent stem cells.	No abstract available
39207047	The trajectory of vesicular proteomic signatures from HBV-HCC by chitosan-magnetic bead-based separation and DIA-proteomic analysis.	No abstract available
41068253	Identification of plasma extracellular vesicle protein biomarkers in diabetic retinopathy progression.	No abstract available