Protein detail
E41L3
Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed]
Protein symbol E41L3 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification Plasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed]
Protein Class
Plasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
4.1BDAL1KIAA0987
Gene Description
Erythrocyte membrane protein band 4.1 like 3
Chromosome
18
Position
5392381-5630700
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificAstrocytesSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificneutrophilBlood Lineage Specificdendritic cellsSecretome LocationIntracellular and membraneSecretome FunctionReceptor
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
5 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| EPB41L3 | CDK2 | P24941 | T | 466 | phosphorylation | MIMPPhosphoSite_MIMP | |
| EPB41L3 | CDK2 | P24941 | T | 467 | phosphorylation | MIMPPhosphoSite_MIMP | |
| EPB41L3 | CDK2 | P24941 | S | 960 | phosphorylation | MIMPPhosphoSite_MIMP | |
| EPB41L3 | CDK2 | P24941 | S | 962 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| EPB41L3 | CSNK1A1 | P48729 | S | 804 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling
17 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| ferm_domain | intracellular_intercellular_related | HGNC | Yes | No | No | No | No |
| intracellular_intercellular_related | intracellular_intercellular_related | OmniPath | Yes | No | No | No | No |
| transmembrane_predicted | transmembrane | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane | TopDB | No | No | No | No | No |
| transmembrane | transmembrane | LOCATE | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
1,087
Mass
120,678
Sequence
MTTESGSDSESKPDQEAEPQEAAGAQGRAGAPVPEPPKEEQQQALEQFAAAAAHSTPVRREVTDKEQEFAARAAKQLEYQQLEDDKLSQKSSSSKLSRSPLKIVKKPKSMQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDPAKEIKKQVRSGAWHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLALLGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHFLENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLLLPEAPPKKFLTLGSKFRYSGRTQAQTRRASALIDRPAPYFERSSSKRYTMSRSLDGEVGTGQYATTKGISQTNLITTVTPEKKAEEERDEEEDKRRKGEEVTPISAIRHEGKSPGLGTDSCPLSPPSTHCAPTSPTELRRRCKENDCKLPGYEPSRAEHLPGEPALDSDGPGRPYLGDQDVAFSYRQQTGKGTTLFSFSLQLPESFPSLLDDDGYLSFPNLSETNLLPQSLQHYLPIRSPSLVPCFLFIFFFLLSASFSVPYALTLSFPLALCLCYLEPKAASLSASLDNDPSDSSEEETDSERTDTAADGETTATESDQEEDAELKAQELEKTQDDLMKHQTNISELKRTFLETSTDTAVTNEWEKRLSTSPVRLAARQEDAPMIEPLVPEETKQSSGEKLMDGSEIFSLLESARKPTEFIGGVTSTSQSWVQKMETKTESSGIETEPTVHHLPLSTEKVVQETVLVEERRVVHASGDASYSAGDSGDAAAQPAFTGIKGKEGSALTEGAKEEGGEEVAKAVLEQEETAAASRERQEEQSAAIHISETLEQKPHFESSTVKTETISFGSVSPGGVKLEISTKEVPVVHTETKTITYESSQVDPGTDLEPGVLMSAQTITSETTSTTTTTHITKTVKGGISETRIEKRIVITGDADIDHDQALAQAIKEAKEQHPDMSVTKVVVHKETEITPEDGED
Alternative Products
Event=Alternative splicing; Named isoforms=4; Comment=Additional isoforms seem to exist.; Name=1; IsoId=Q9Y2J2-1; Sequence=Displayed; Name=2; IsoId=Q9Y2J2-2; Sequence=VSP_000482, VSP_000483, VSP_000484, VSP_000485; Name=3; IsoId=Q9Y2J2-3; Sequence=VSP_000482, VSP_000483, VSP_000484, VSP_000485, VSP_000486; Name=4; IsoId=Q9Y2J2-4; Sequence=VSP_000482, VSP_000483, VSP_054819, VSP_054820
Alternative Sequence
446; G -> GASVNENHEIYMKDSMSAA (in isoform 2, isoform 3 and isoform 4); 503..689; Missing (in isoform 2, isoform 3 and isoform 4); 708..719; Missing (in isoform 2 and isoform 3); 784..824; Missing (in isoform 2 and isoform 3); 835..1087; Missing (in isoform 3); 1052; A -> E (in isoform 4); 1053..1087; Missing (in isoform 4)
3D Structural Models
Turn
242..244; 249..252; 273..276; 294..297; 354..357
Helix
132..142; 148..150; 172..175; 193..195; 199..214; 222..237; 261..272; 279..290; 334..336; 370..389
Beta Strand
109..115; 121..127; 151..156; 162..164; 169..171; 180..188; 256..258; 299..305; 310..315; 317..333; 337..343; 346..351; 361..366
3D Structure
X-ray crystallography (54)
Domain & Motif Annotations
Compositional Bias
20..32; Low complexity; 459..469; Polar residues; 516..526; Polar residues; 681..691; Acidic residues; 698..707; Low complexity; 947..960; Polar residues
Domain (FT)
110..391; FERM
Region
1..43; Disordered; 394..513; Hydrophilic; 459..529; Disordered; 514..860; Spectrin--actin-binding; 541..563; Disordered; 675..715; Disordered; 861..1083; C-terminal (CTD); 937..965; Disordered
Clinical Relevance
Disease Involvement
Tumor suppressor
Antibody
Interaction Protein
ENSG00000074201ENSG00000134308ENSG00000137497ENSG00000164924ENSG00000165868ENSG00000166913ENSG00000170027
Interaction Count
7
Interaction Dataset
biogrid_opencellintact_biogrid