Protein detail
S27A5
Long-chain fatty acid transport protein 5 (FATP-5) (Fatty acid transport protein 5) (Bile acid-CoA ligase) (BA-CoA ligase) (BAL) (Bile acyl-CoA synthetase) (BACS) (EC 6.2.1.7) (Cholate--CoA ligase) (Fatty-acid-coenzyme A ligase, very long-chain 3) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 5) (Very long-chain acyl-CoA synthetase homolog 2) (VLCS-H2) (VLCSH2) (EC 6.2.1.-) (Very long-chain acyl-CoA synthetase-related protein) (VLACS-related) (VLACSR)
Entry name S27A5 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) | Transmembrane count 2 | Protein classification EnzymesMetabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information12
Protein Names
Long-chain fatty acid transport protein 5 (FATP-5) (Fatty acid transport protein 5) (Bile acid-CoA ligase) (BA-CoA ligase) (BAL) (Bile acyl-CoA synthetase) (BACS) (EC 6.2.1.7) (Cholate--CoA ligase) (Fatty-acid-coenzyme A ligase, very long-chain 3) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 5) (Very long-chain acyl-CoA synthetase homolog 2) (VLCS-H2) (VLCSH2) (EC 6.2.1.-) (Very long-chain acyl-CoA synthetase-related protein) (VLACS-related) (VLACSR)
Protein Class (5)
EnzymesMetabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function (4)
- Transporters
- Enzymes
- ENZYME proteins:Ligase
- Predicted intracellular proteins
Transmembrane
31..51; Helical; 56..76; Helical
Transmembrane Count
2
Ensembl
Entrez Gene Symbol
Gene Synonym (8)
ACSBACSVL6FACVL3FATP5FLJ22987VLACSRVLCS-H2VLCSH2
Gene Description
Solute carrier family 27 member 5
Chromosome
19
Position
58479512-58512413
EVMP confidence score
0.38
Fluorescence & Localization5
Tissue SpecifickidneyCell SpecificAlveolar cells type 1Single-Nuclei Brain Specifichippocampal dentate gyrusSecretome LocationIntracellular and membraneSecretome FunctionDevelopmental protein
Function & Pathway7
Protein Function (4)
- Transporters
- Enzymes
- ENZYME proteins:Ligase
- Predicted intracellular proteins
Cellular Component (5)
Molecular Function (8)
- GO:0004467 long-chain fatty acid-CoA ligase activity
- GO:0005324 long-chain fatty acid transmembrane transporter activity
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0016491 oxidoreductase activity
- GO:0031957 very long-chain fatty acid-CoA ligase activity
- GO:0044877 protein-containing complex binding
- GO:0047747 cholate-CoA ligase activity
Biological Process (3)
KEGG (5)
Reactome (7)
- R-hsa-194068 bile acid and bile salt metabolism
- R-hsa-556833 metabolism of lipids
- R-hsa-8957322 metabolism of steroids
- R-hsa-159418 recycling of bile acids and salts
- R-hsa-192105 synthesis of bile acids and bile salts
- R-hsa-193775 synthesis of bile acids and bile salts via 24 hydroxycholesterol
- R-hsa-193368 synthesis of bile acids and bile salts via 7alpha hydroxycholesterol
Mediation Categories (2)
Fusion and delivery mediationMetabolism mediation
Relations & Evidence18
Ligand-Receptor Signaling (17)
17 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | LOCATE | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Sequence, Structure & Domains7
Sequences
Length
690
Mass
75,385
Sequence
MGVRQQLALLLLLLLLLWGLGQPVWPVAVALTLRWLLGDPTCCVLLGLAMLARPWLGPWVPHGLSLAAAALALTLLPARLPPGLRWLPADVIFLAKILHLGLKIRGCLSRQPPDTFVDAFERRARAQPGRALLVWTGPGAGSVTFGELDARACQAAWALKAELGDPASLCAGEPTALLVLASQAVPALCMWLGLAKLGCPTAWINPHGRGMPLAHSVLSSGARVLVVDPDLRESLEEILPKLQAENIRCFYLSHTSPTPGVGALGAALDAAPSHPVPADLRAGITWRSPALFIYTSGTTGLPKPAILTHERVLQMSKMLSLSGATADDVVYTVLPLYHVMGLVVGILGCLDLGATCVLAPKFSTSCFWDDCRQHGVTVILYVGELLRYLCNIPQQPEDRTHTVRLAMGNGLRADVWETFQQRFGPIRIWEVYGSTEGNMGLVNYVGRCGALGKMSCLLRMLSPFELVQFDMEAAEPVRDNQGFCIPVGLGEPGLLLTKVVSQQPFVGYRGPRELSERKLVRNVRQSGDVYYNTGDVLAMDREGFLYFRDRLGDTFRWKGENVSTHEVEGVLSQVDFLQQVNVYGVCVPGCEGKVGMAAVQLAPGQTFDGEKLYQHVRAWLPAYATPHFIRIQDAMEVTSTFKLMKTRLVREGFNVGIVVDPLFVLDNRAQSFRPLTAEMYQAVCEGTWRL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y2P5-1; Sequence=Displayed; Name=2; IsoId=Q9Y2P5-2; Sequence=VSP_055810
Alternative Sequence
146..229; Missing (in isoform 2)
Domain & Motif Annotations
Protein Families
ATP-dependent AMP-binding enzyme family
Sequence Similarities
Belongs to the ATP-dependent AMP-binding enzyme family.