Protein detail
AXIN2
Axin-2 (Axin-like protein) (Axil) (Axis inhibition protein 2) (Conductin)
Protein symbol AXIN2 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Axin-2 (Axin-like protein) (Axil) (Axis inhibition protein 2) (Conductin)
Protein Class
Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins
Protein Function
- Cancer-related genes:Mutational cancer driver genes
- Human disease related genes:Cancers:Cancers of the digestive system
- Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
- Predicted intracellular proteins
- Cancer-related genes:Mutated cancer genes
- Human disease related genes:Digestive system diseases:Mouth and dental diseases
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym
DKFZp781B0869MGC126582
Gene Description
Axin 2
Chromosome
17
Position
65528563-65561648
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecificcervixCell SpecificEndometrial ciliated cells
Function & Pathway
Protein Function
- Cancer-related genes:Mutational cancer driver genes
- Human disease related genes:Cancers:Cancers of the digestive system
- Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
- Predicted intracellular proteins
- Cancer-related genes:Mutated cancer genes
- Human disease related genes:Digestive system diseases:Mouth and dental diseases
- Disease related genes
Cellular Component
Molecular Function
Biological Process
KEGG
- hsa04310 Wnt signaling pathway
- KEGG:hsa04390 Hippo signaling pathway
- KEGG:hsa04519 Cadherin signaling
- KEGG:hsa04550 Signaling pathways regulating pluripotency of stem cells
- KEGG:hsa04934 Cushing syndrome
- KEGG:hsa05010 Alzheimer disease
- KEGG:hsa05022 Pathways of neurodegeneration - multiple diseases
- KEGG:hsa05165 Human papillomavirus infection
- KEGG:hsa05200 Pathways in cancer
- KEGG:hsa05210 Colorectal cancer
- KEGG:hsa05213 Endometrial cancer
- KEGG:hsa05217 Basal cell carcinoma
- KEGG:hsa05224 Breast cancer
- KEGG:hsa05225 Hepatocellular carcinoma
- KEGG:hsa05226 Gastric cancer
Reactome
- R-hsa-3858494 beta catenin independent wnt signaling
- R-hsa-4411364 binding of tcf lef ctnnb1 to target gene promoters
- R-hsa-4086398 ca2 pathway
- R-hsa-4641257 degradation of axin
- R-hsa-195253 degradation of beta catenin by the destruction complex
- R-hsa-5688426 deubiquitination
- R-hsa-201722 formation of the beta catenin tcf transactivating complex
- R-hsa-597592 post translational protein modification
- R-hsa-4641265 repression of wnt target genes
- R-hsa-195721 signaling by wnt
- R-hsa-201681 tcf dependent signaling in response to wnt
- R-hsa-5689880 ub specific processing proteases
Mediation Categories
Metabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| AXIN2 | PLK1 | P53350 | S | 311 | phosphorylation | REACH_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper | ProtMapper:28415805 |
Ligand-Receptor Signaling
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
8 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | R Sequencing | 1 | 40222457 |
Sequence, Structure & Domains
Sequences
Length
843
Mass
93,568
Sequence
MSSAMLVTCLPDPSSSFREDAPRPPVPGEEGETPPCQPGVGKGQVTKPMPVSSNTRRNEDGLGEPEGRASPDSPLTRWTKSLHSLLGDQDGAYLFRTFLEREKCVDTLDFWFACNGFRQMNLKDTKTLRVAKAIYKRYIENNSIVSKQLKPATKTYIRDGIKKQQIDSIMFDQAQTEIQSVMEENAYQMFLTSDIYLEYVRSGGENTAYMSNGGLGSLKVVCGYLPTLNEEEEWTCADFKCKLSPTVVGLSSKTLRATASVRSTETVDSGYRSFKRSDPVNPYHIGSGYVFAPATSANDSEISSDALTDDSMSMTDSSVDGIPPYRVGSKKQLQREMHRSVKANGQVSLPHFPRTHRLPKEMTPVEPATFAAELISRLEKLKLELESRHSLEERLQQIREDEEREGSELTLNSREGAPTQHPLSLLPSGSYEEDPQTILDDHLSRVLKTPGCQSPGVGRYSPRSRSPDHHHHHHSQYHSLLPPGGKLPPAAASPGACPLLGGKGFVTKQTTKHVHHHYIHHHAVPKTKEEIEAEATQRVHCFCPGGSEYYCYSKCKSHSKAPETMPSEQFGGSRGSTLPKRNGKGTEPGLALPAREGGAPGGAGALQLPREEGDRSQDVWQWMLESERQSKPKPHSAQSTKKAYPLESARSSPGERASRHHLWGGNSGHPRTTPRAHLFTQDPAMPPLTPPNTLAQLEEACRRLAEVSKPPKQRCCVASQQRDRNHSATVQTGATPFSNPSLAPEDHKEPKKLAGVHALQASELVVTYFFCGEEIPYRRMLKAQSLTLGHFKEQLSKKGNYRYYFKKASDEFACGAVFEEIWEDETVLPMYEGRILGKVERID
3D Structural Models
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
56..69; Basic and acidic residues; 477..494; Low complexity; 588..597; Low complexity; 727..741; Polar residues
Motif
21..30; Tankyrase-binding motif
Domain (CC)
The tankyrase-binding motif (also named TBD) is required for interaction with tankyrase TNKS and TNKS2..
Domain (FT)
81..200; RGS; 761..843; DIX
Region
1..75; Disordered; 327..413; Interaction with GSK3B; 334..393; Interaction with SIAH1 and SIAH2; 396..435; Disordered; 413..476; Interaction with beta-catenin; 447..494; Disordered; 561..674; Disordered; 718..748; Disordered