Protein detail
AXIN2
Axin-2 (Axin-like protein) (Axil) (Axis inhibition protein 2) (Conductin)
Entry name AXIN2 | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Axin-2 (Axin-like protein) (Axil) (Axis inhibition protein 2) (Conductin)
Protein Class (5)
Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins
Protein Function (7)
- Cancer-related genes:Mutational cancer driver genes
- Human disease related genes:Cancers:Cancers of the digestive system
- Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
- Predicted intracellular proteins
- Cancer-related genes:Mutated cancer genes
- Human disease related genes:Digestive system diseases:Mouth and dental diseases
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
DKFZp781B0869MGC126582
Gene Description
Axin 2
Chromosome
17
Position
65528563-65561648
Supporting publications (n)
1
EVMP confidence score
0.40
Fluorescence & Localization
Tissue SpecificcervixCell SpecificEndometrial ciliated cells
Function & Pathway
Protein Function (7)
- Cancer-related genes:Mutational cancer driver genes
- Human disease related genes:Cancers:Cancers of the digestive system
- Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
- Predicted intracellular proteins
- Cancer-related genes:Mutated cancer genes
- Human disease related genes:Digestive system diseases:Mouth and dental diseases
- Disease related genes
Cellular Component (6)
Molecular Function (7)
Biological Process (3)
KEGG (15)
- hsa04310 Wnt signaling pathway
- KEGG:hsa04390 Hippo signaling pathway
- KEGG:hsa04519 Cadherin signaling
- KEGG:hsa04550 Signaling pathways regulating pluripotency of stem cells
- KEGG:hsa04934 Cushing syndrome
- KEGG:hsa05010 Alzheimer disease
- KEGG:hsa05022 Pathways of neurodegeneration - multiple diseases
- KEGG:hsa05165 Human papillomavirus infection
- KEGG:hsa05200 Pathways in cancer
- KEGG:hsa05210 Colorectal cancer
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Reactome (12)
- R-hsa-3858494 beta catenin independent wnt signaling
- R-hsa-4411364 binding of tcf lef ctnnb1 to target gene promoters
- R-hsa-4086398 ca2 pathway
- R-hsa-4641257 degradation of axin
- R-hsa-195253 degradation of beta catenin by the destruction complex
- R-hsa-5688426 deubiquitination
- R-hsa-201722 formation of the beta catenin tcf transactivating complex
- R-hsa-597592 post translational protein modification
- R-hsa-4641265 repression of wnt target genes
- R-hsa-195721 signaling by wnt
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Mediation Categories (2)
Metabolism mediationReceptor-signaling mediation
Relations & Evidence16
Enzyme-Mediated Modification (1)
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| AXIN2 | PLK1 | P53350 | S | 311 | phosphorylation | REACH_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper | ProtMapper:28415805 |
Ligand-Receptor Signaling (4)
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath |
Regulatory Interaction Network (8)
8 records.
Protein Complex Composition (2)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | R Sequencing | 1 | 40222457 |
Sequence, Structure & Domains
Sequences
Length
843
Mass
93,568
Sequence
MSSAMLVTCLPDPSSSFREDAPRPPVPGEEGETPPCQPGVGKGQVTKPMPVSSNTRRNEDGLGEPEGRASPDSPLTRWTKSLHSLLGDQDGAYLFRTFLEREKCVDTLDFWFACNGFRQMNLKDTKTLRVAKAIYKRYIENNSIVSKQLKPATKTYIRDGIKKQQIDSIMFDQAQTEIQSVMEENAYQMFLTSDIYLEYVRSGGENTAYMSNGGLGSLKVVCGYLPTLNEEEEWTCADFKCKLSPTVVGLSSKTLRATASVRSTETVDSGYRSFKRSDPVNPYHIGSGYVFAPATSANDSEISSDALTDDSMSMTDSSVDGIPPYRVGSKKQLQREMHRSVKANGQVSLPHFPRTHRLPKEMTPVEPATFAAELISRLEKLKLELESRHSLEERLQQIREDEEREGSELTLNSREGAPTQHPLSLLPSGSYEEDPQTILDDHLSRVLKTPGCQSPGVGRYSPRSRSPDHHHHHHSQYHSLLPPGGKLPPAAASPGACPLLGGKGFVTKQTTKHVHHHYIHHHAVPKTKEEIEAEATQRVHCFCPGGSEYYCYSKCKSHSKAPETMPSEQFGGSRGSTLPKRNGKGTEPGLALPAREGGAPGGAGALQLPREEGDRSQDVWQWMLESERQSKPKPHSAQSTKKAYPLESARSSPGERASRHHLWGGNSGHPRTTPRAHLFTQDPAMPPLTPPNTLAQLEEACRRLAEVSKPPKQRCCVASQQRDRNHSATVQTGATPFSNPSLAPEDHKEPKKLAGVHALQASELVVTYFFCGEEIPYRRMLKAQSLTLGHFKEQLSKKGNYRYYFKKASDEFACGAVFEEIWEDETVLPMYEGRILGKVERID
3D Structural Models
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
56..69; Basic and acidic residues; 477..494; Low complexity; 588..597; Low complexity; 727..741; Polar residues
Motif
21..30; Tankyrase-binding motif
Domain (CC)
The tankyrase-binding motif (also named TBD) is required for interaction with tankyrase TNKS and TNKS2..
Domain (FT)
81..200; RGS; 761..843; DIX
Region
1..75; Disordered; 327..413; Interaction with GSK3B; 334..393; Interaction with SIAH1 and SIAH2; 396..435; Disordered; 413..476; Interaction with beta-catenin; 447..494; Disordered; 561..674; Disordered; 718..748; Disordered
Clinical Relevance
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 37713494 | ATP1A3 as a target for isolating neuron-specific extracellular vesicles from human brain and biofluids. | No related sentences available |